fa تماس شغلی با بنزن و عوارض هماتولوژیک ناشی از آن مقاله پژوهشی Original Research Article <div style="text-align: justify;"><strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Background:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;"> Considering the myelotoxic and leukemogenic effects of benzene on humans and to determine the concentration of benzene vapors in work places this study was carried out in one of the benzene-producing factories in Isfahan, Iran.</span></span><br> <strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;"> In this case-control study, forty age and sex matched workers who were occupationally exposed to benzene and forty people who were not exposed to benzene were selected. Air sampling from workplaces was carried out based on NIOSH recommendations, and the samples were analyzed using gas chromatography equipment. Hematological parameters were measured using Sysmex hematology analyser. The differential distribution of leukocytes and alkaline phosphatase in granulocytes, and also nitroblue tetrazolium reduction (NBT) in neutrophils were evaluated by microscopic methods.</span></span><br> <strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;"> Benzene concentration in some workplaces was higher than standard values (3.99 ppm vs.lppm). There was no statistically significant difference in non-hematological parameters such as age, length of service and smoking, and also in hematological indices between the two groups. However, mean Hct, leukocyte alkaline phosphatase (LAP), and NBT reduction were associated with a significant increase in exposed workers (P<0.05).</span></span><br> <strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;"> Increment in LAP activity and NBT reduction found in exposed workers in some workplaces may be due to neutrophilic lineage stimulation by benzene and its metabolites.</span></span></div> BENZENE, NEUTROPHILFUNCTION, HEMATOLOGICAL CONSEQUENCES LEUKOCYTE ALKALINE PHOSPHATASE 13 20 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-158&slc_lang=fa&sid=1 Shahrzad Zamanipour شهرزاد زمانی پور 5200319475328460069941 5200319475328460069941 Yes Yousef Mortazavi یوسف مرتضوی 5200319475328460069942 5200319475328460069942 No Saeed Kaviani سعید کاویانی 5200319475328460069943 5200319475328460069943 No