fa تاثیر مصرف دراز مدت ویتامین ث بر انقباضات حاصل از کلرید پتاسیم و فنیل‌افرین درآئورت جدا شده‌ موش صحرایی مقاله پژوهشی Original Research Article <table border="0" cellpadding="0" cellspacing="0"> <tbody> <tr> <td colspan="2" style="text-align: justify;"><strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Background:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;"> Vitamin C is the most effective water soluble antioxidant substance. Many studies have shown an inverse relationship between the intake of vitamin C and the disorders of cardiovascular system. In this study the effect of vit C intake on contractility of isolated aorta in rats was investigated. </span></span><br> <strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;"> 60 female wistar rats weighing 180-220g were divided into control (CG) and test groups (TG) as TG1W, TG2W, TG3W, TG4W and TG8W. They received 0.3% vitamin C in drinking water for 1, 2, 3, 4 and 8 weeks respectively. The animals were anesthetized with sodium pentobarbital (50 mg/kg/ip). The chests were opened and the thoracic aortas were removed. The endothelium layer was denuded and a ring of aorta (5-6 mm) was mounted in oxygenated Krebs solution containing organ bath at 37&deg;c and pH=7.4. After a recovery period (90 min), various concentrations of KCl or phenylepherine (phe) were added. The results were reported as mean (SE g/mm2) and compared with ANOVA followed by Turkey&#39;s post-Hoc test. A value of P<0.05 was considered significant. </span></span><br> <strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;"> There were no significant differences in aortic responses of CG, TG1W and TG2W to KCl and phenylepherine. Potassium chloride in 50, 60 and 75 mmole concentrations in TG3W and TG4W produced tensions of 2&plusmn;0.2, 2.2&plusmn;0.2, 2.3&plusmn;0.2, 1.96&plusmn;0.2, 1.9&plusmn;0.1, 1.97&plusmn;0.1 g/mm2 respectively. In TG8W the same concentrations of KCl produced tensions of 1.5&plusmn; 1,1.6&plusmn;0.1, 1.6&plusmn;0.1 g/mm2. These tensions are significantly (P<0.05) less than the control group. In the aorta, phenylepherine in 1, 5 micromole concentration in TG3W and TG4W produced tensions of 3.2&plusmn;0.1, 3.5&plusmn;0.2, 2.7&plusmn;0.1, 3&plusmn;0.1 g/mm2 respectively, and in TG8W produced, 2.5&plusmn;0.2, 2.7&plusmn;0.2 g/mm2. These tensions are significantly (P<0.05) less than control group. </span></span><br> <strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;"> High vitamin C intake in the diet can reduce the aorta contractility in rats.</span></span></td> </tr> <tr> <td colspan="2" style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;">&nbsp;</span></span></td> </tr> </tbody> </table> <div style="text-align: justify;"></div> VIT C, AORTA, RAT 1 9 http://journal.zums.ac.ir/browse.php?a_code=A-10-1-50&slc_lang=fa&sid=1 Saleh Zahediasl زاهدی اصل صالح 5200319475328460070126 5200319475328460070126 No Naser Pazhohi پژوهی ناصر 5200319475328460070127 5200319475328460070127 Yes Mohammad Badavi بدوی محمد 5200319475328460070128 5200319475328460070128 No Raheleh Asaei عصایی راحله 5200319475328460070129 5200319475328460070129 No