fa تاثیر هشت هفته تمرین تناوبی شدید بر بیان ژن عوامل رگ‌زایی در موش‌های صحرایی مبتلا به ایسکمی میوکارد کارآزمایی بالینی Clinical Trials <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><span style="color:#008080;"><strong><em>Background and Objective</em></strong><span dir="RTL">:</span></span> Myocardial infraction can lead to loss of heart muscle cell, changes in ventricular function and structure, scar formation as well as leading the heart to ultimate stroke and its loss. This study aimed to investigate the effect of eight weeks of High-Intensity Interval Training (HIIT) on the gene expression of angiogenesis factors in ischemic rats.<br> <span style="color:#008080;"><strong><em>Materials and Methods</em></strong>:</span> In this study, 28 male Wistar rats (200-250 g) were randomly assigned to 4 groups: sham, ischemia, exercise, and exercise-ischemia. Myocardial infarction (MI) was achieved via closure of LAD artery for 30 minutes. A treadmill exercise program was performed by the rats for 8 weeks, 40 minutes daily, 3 days a week.<br> <span style="color:#008080;"><strong><em>Results</em></strong>:</span> The results showed that there is a significant difference between the four groups in gene expression levels of VEGF, apelin and apelin receptor (p = 0.001). Results also showed that the gene expression level of VEGF, apelin and apelin receptor was significantly increased in the exercise-ischemia group compared to sham (p = 0.04), ischemia (p = 0.002) and exercise (p = 0.009) groups. Results showed that exercise during ischemia can lead to an increase in VEGF gene expression but not in exercise group alone. On the other hand, a significant increase was observed in gene expression level of apelin following ischemic intervention compared to the sham group (p = 0.025). No difference was observed between the interval training group and sham group (p > 0.05). Meanwhile, a significant reduction in <span style="color:#008080;">the gene expression level of apelin receptor was seen following ischemic intervention compared to the sham group (p = 0.04).<br> <strong><em>Conclusion</em></strong><em>:</em></span> The physiological adaptations caused by interval training are associated with different gene expressions. A regular interval training program leads to the increase of factors involved in angiogenesis and the regeneration of cardiac muscle vessels following myocardial ischemia.</span></span></p> Keywords: Myocardial ischemic, Angiogenesis, Intensity interval training, Apelin 20 34 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-1081&slc_lang=fa&sid=1 Yaghoub Mehri Alvar یعقوب مهری الوار 5200319475328460051010 5200319475328460051010 Yes Dept. of Exercise Physiology, Shahid Rajaee Teacher Training University, Tehran, Iran دانشجوی دکترای فیزیولوژی ورزشی، دانشکده‌ی علوم ورزشی، دانشگاه تربیت دبیر شهید رجایی، تهران Alireza Ramezani علیرضا رمضانی 5200319475328460051011 5200319475328460051011 No Dept. of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran دکترای تخصصی فیزیولوژی، دانشیارگروه فیزیولوژی ورزشی، دانشکده‌ی علوم ورزشی، دانشگاه تربیت دبیر شهیدرجایی، تهران Abbas Ali Gaeeni عباسعلی گاینی 5200319475328460051012 5200319475328460051012 No Dept. of Exercise Physiology, Shahid Rajaee Teacher Training University, Tehran, Iran دکترای تخصصی فیزیولوژی، استاد گروه فیزیولوژی ورزشی، دانشکده‌ی علوم ورزشی، دانشگاه تهران، تهران Fereshteh Golab فرشته گلاب 5200319475328460051013 5200319475328460051013 No Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran دکترای تخصصی فیزیولوژی، استادیار مرکز تحقیقات سلولی و ملوکولی، دانشگاه علوم پزشکی ایران، تهران Riaz gheiratmand ریاض غیرتمند 5200319475328460051014 5200319475328460051014 No Dept. of Cardiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran متخصص قلب و عروق، گروه هماتولوژی کودکان، بیمارستان شهدا، دانشگاه علوم پزشکی شهید بهشتی، تهران Mahmoud Barati محمود براتی 5200319475328460051015 5200319475328460051015 No Dept. of Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran گروه بیوتکنولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی تهران، تهران