fa بررسی اثر عصاره هیدروالکلی گیاه خوشاریزه (Echinophora platyloba L.) بر غلظت سرمی تستوسترون و گنادوتروپین‌ها در موش صحرایی نر القا شده با تتراکلرید کربن کارآزمایی بالینی Clinical Trials <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong><em><span style="color:#008080;">Background and Objective:</span> </em></strong>Carbon tetrachloride is one of the chemical toxins widely used in hygiene industries. The aim of this study was to investigate the effects of <em>Echinophora platyloba</em> extract (EPE) on serum levels of testosterone and gonadotropins in male rats induced with carbon tetrachloride.<br> <span style="color:#008080;"><strong><em>Materials and Methods:</em></strong></span> In this experimental study 49&nbsp; male Wistar&nbsp; rats (220-250 g) were randomly divided into seven groups (n=7): Control group (2 ml/kg&nbsp; normal saline, daily for 4 days, ip), toxicant group (2 ml/kg CCl₄+olive oil.1:1, single dose ,ip), sham group (2 ml/kg&nbsp; olive oil, single dose, ip), positive control group (400 mg/kg EPE daily for 4 days, ip), toxicant-treated groups 1, 2 and 3 (CCl₄+ olive oil.1:1, single dose and 200 and 400 and 800 mg/kg of EPE, respectively, daily for 4 days, ip). At the end of the treatments, serum testosterone and FSH & LH hormones were measured.<br> <span style="color:#008080;"><strong><em>Results:</em></strong></span> CCL₄ resulted in significantly decreased testosterone and increased FSH & LH serum levels in the toxicant group compared with the control group (P<0.001). EPE treatment with 400 and 800 mg/kg resulted in a significant increase in testosterone and decrease in FSH & LH serum levels compared with the toxicant group (P<0.001).&nbsp;&nbsp;&nbsp;<br> <strong><em><span style="color:#008080;">Conclusion:</span> </em></strong>Hydro-ethanolic <em>E</em>.<em> platyloba</em> extract increased serum levels of testosterone and decreased FSH and LH serum levels in male rats induced with CCL₄.</span></span></p> Keywords: Echinophora platyloba, FSH & LH, Testosterone, Carbon-tetrachloride, Rat 111 121 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-1087&slc_lang=fa&sid=1 Nanser Mirazi ناصر میرازی Mirazi205@gmail.com 5200319475328460051016 5200319475328460051016 Yes Dept. of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Hamedan- Iran دکترای تخصصی فیزیولوژی، دانشیار گروه زیست شناسی، دانشکده‌ی علوم پایه، دانشگاه بوعلی سینا، همدان Elham Norbar الهام نوربار 5200319475328460051017 5200319475328460051017 No Dept. of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Hamedan- Iran کارشناس ارشد فیزیولوژی، گروه زیست شناسی، دانشکده‌ی علوم پایه، دانشگاه بوعلی سینا، همدان Maryam Soleymani مریم سلیمانی 5200319475328460051018 5200319475328460051018 No Dept. of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Hamedan- Iran کارشناس ارشد فیزیولوژی، گروه زیست شناسی، دانشکده‌ی علوم پایه، دانشگاه بوعلی سینا، همدان