fa اثر ضد درد تزریق لیدوکائین داخل وریدی در سزارین تحت بی حسی نخاعی: یک مطالعه تصادفی آینده نگر دو سو کور Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-family:times new roman;"><span style="font-size:14px;"><span style="color:#008080;"><strong>Background & Objective:</strong></span> Nowadays, conventional analgesic agents that are usually used for pain killing after cesarean sections do not provide enough analgesia with infrequent serious side effects. Lidocaine has been suggested as an adjuvant analgesic agent for postoperative pain relief. We designed this randomized double-blind, placebo-controlled study to evaluate the analgesic efficacy of intravenous (IV) lidocaine in patients undergoing a cesarean section under spinal anesthesia.<br> <strong><span style="color:#008080;">Materials & Methods:</span></strong> Eighty patients undergoing elective cesarean section under spinal anesthesia were randomly divided into two groups to receive intravenous 1.5 mg/kg of lidocaine 2% bolus 15 minutes prior to spinal anesthesia followed by an intravenous infusion of 1.5 mg/kg/h for 60 minutes (L group) or 0.9% sodium chloride (C group) in a double-blind fashion. The time until the first request for an analgesic, the duration of sensory and motor blockade, hemodynamic variables and adverse events were recorded.<br> <span style="color:#008080;"><strong>Results: </strong></span>The difference in sensory (95% CI 10.18 to 18.01; <em>P</em>&le;0.001) and motor (95% CI 35.50 to 50.19; <em>P</em>&le;0.001) blockade durations between groups L and C were significant. Similarly, the mean time until the first analgesic request was longer in group L (175.37&plusmn;21.43) than in group C (157.12&plusmn;15.25); the difference between the two groups was significant (95% CI9.95 to 26.54; <em>P</em><0.001).<br> <span style="color:#008080;"><strong>Conclusion: </strong></span>Intravenous lidocaine given as a supplementary agent in patients undergoing cesarean section under spinal anesthesia prolonged the duration of the sensory and motor blockade of spinal anesthesia and delayed the first analgesic request by patients without hemodynamic disturbance, respiratory depression and compromising the fetus.</span></span></p> Anesthesia, Cesarean section, Pain, Lidocaine, Spinal 31 37 http://journal.zums.ac.ir/browse.php?a_code=A-10-4377-1&slc_lang=fa&sid=1 Marzieh Beigom Khezri مرضیه بیگم خضری mkhezri@qums.ac.ir 5200319475328460088679 5200319475328460088679 No Dept. of Anesthesiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Maryam Rajabi مریم رجبی dr.108162@gmail.com 5200319475328460088680 5200319475328460088680 Yes Dept. of Anesthesiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Siyamak Yaghobi سیامک یعقوبی Drsiamakyaghoubi@gmail.com 5200319475328460088681 5200319475328460088681 No Dept. of Anesthesiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Hamideh Pakniat حمیده پاک نیت hpakniat@qums.ac.ir 5200319475328460088682 5200319475328460088682 No Dept. of Obstetrics and Gynecology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran