en بررسی عوامل موثر بر تکثیر سلول های بنیادی عصبی Life Science Life Science مقاله مروری Review Article <p style="text-align: justify;"><span style="font-family:times new roman;"><span style="font-size:16px;">Neural stem cells are undifferentiated cells that are located in limited areas of central nervous system. These cells have proliferation and self-renew ability and can be differentiated into neurons and glial cells. Mature nerve cells do not have proliferative ability; and due to the limited number of nerve stem cells, injuries to the nervous system are not recoverable. The purpose of this review is to identify characteristics and factors that may influence proliferation and differentiation of neural stem cells. These cells provide useful tools for in vitro study of neural cells developmental stages. Besides, they have extensive therapeutic applications providing an unlimited source of cells for tissue transplantation and repair. Overall, the identification of factors contributing to neural stem cell&#39;s proliferation and differentiation can be effective for body&#39;s natural capacity to repair nerve damages. For cell therapy purposes, application of induced medium or an appropriate stimulants may have an effective role in increasing the rate of growth and proliferation of these cells in vitro.</span></span></p> Differentiation, Neural Stem Cells, Neurogenesis, Proliferation 1 8 http://journal.zums.ac.ir/browse.php?a_code=A-10-1796-5&slc_lang=en&sid=1 Farzaneh Fakheri fakheri@iasbs.ac.ir 5200319475328460048787 5200319475328460048787 No Dept. of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Paria Jafari p.jafary74@yahoo.com 5200319475328460048788 5200319475328460048788 No School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Azadeh Moloudi azadehmoloudi74@gmail.com 5200319475328460048789 5200319475328460048789 No School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Sara Asdaghpour s.asdaghpour@yahoo.com 5200319475328460048790 5200319475328460048790 No School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Alireza Abdanipour abdani.anatomy@yahoo.com 5200319475328460048791 5200319475328460048791 Yes School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran