en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="line-height:2;">Acute myocardial infarction (MI) is caused due to coronary artery occlusion and divided into two forms of ST-elevation (STEMI) and non-ST-elevation (NSTEMI) myocardial infarction. This study aimed to determine the success rate of treatment with primary PCI (percutaneous coronary intervention) versus thrombolysis in the establishment of perfusion and to evaluate the short-term complications caused by each method.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="line-height:2;">In this prospective cohort study, 90 patients were selected for primary PCI treatment and 90 patients for thrombolytic treatment. Clinical data and basic demographic characteristics of the patients and cardiovascular risk factors were recorded. The success rate of coronary reperfusion by primary PCI and thrombolytic therapy was then determined by angiography and 90-minute ECG with resolution or improvement of chest pain. All patients were examined for any serious complications such as cerebrovascular accidents, shock, and heart failure for 30 days after treatment. Data were analyzed using SPSS ver. 20.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="line-height:2;"><span style="background:white">In the primary PCI group, 75.6% of the patients were males, and 24.4% were females, but in the thrombolytic group, 76.6% and 23.3% of the cases were males and females, respectively. The mean door-to-balloon time for PCI was 63.60 &plusmn; 23.92 and was 53.70 &plusmn;21.52 min in the thrombolytic group. Thrombolysis in myocardial infarction (TIMI) flow grade III and TIMI-II were the most frequent in primary PCI and thrombolytic groups, respectively.</span> The odds ratio (OD) of mechanical MI and major arrhythmia in patients received the primary PCI compared to those received thrombolytic therapy was 0.24 and 0.66, respectively. Also, the OD of mortality in the primary PCI group was 2.12.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="line-height:2;">Our findings suggest that in STEMI patients, the chances of short-term complications such as post-MI mechanical complications, major arrhythmia, and bleeding requiring blood transfusion were lower in patients who were treated with primary PCI than those who received thrombolytic treatment. Also, the average hospitalization in CCU and hospital in the primary PCI group was lower than the thrombolytic group.</span></span></span></p> Primary PCI, Thrombolytic, Fibrinolysis, ST-Elevation Myocardial Infarction (STEMI) 32 39 http://journal.zums.ac.ir/browse.php?a_code=A-10-3497-3&slc_lang=en&sid=1 Soleiman Gharanjik sgharanjik@gmail.com 5200319475328460078960 0009-0004-0651-0404 No Dept. of Cardiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Morteza Motedayen mor.mot2@gmail.com 5200319475328460078961 5200319475328460078961 No Dept.of Cardiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Reza Hasanzadeh Makoui makoui42@yahoo.com 5200319475328460078962 5200319475328460078962 No Dept. of Cardiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Nima Motamed nima.motamed@zums.ac.ir 5200319475328460078963 5200319475328460078963 No School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Minoo Emami minoo.emami68@gmail.com 5200319475328460078964 5200319475328460078964 No School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Armin Bordbar dr.bordbar.armin@gmail.com 5200319475328460078965 5200319475328460078965 No Dept. of Cardiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Mohammad Reza Jamshidi jamshidianes@zums.ac.ir 5200319475328460078966 5200319475328460078966 No Dept. of Cardiac Anesthesiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Reza Madadi drrezamadadi@zums.ac.ir 5200319475328460078967 5200319475328460078967 Yes Dept. of Cardiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran