en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-family:times new roman;"><span style="font-size:16px;"><span style="color:#008080;"><strong>Background and Objective: </strong></span>Different studies have investigated the link between helicobacter pylori and extra digestive diseases such as idiopathic thrombocytopenic purpura. However, the relationship between ITP and <em>H pylori</em> is less clear. Most of the studies have focused on <em>H pylori</em> eradication in chronic ITP, so we focused on the effect of <em>H pylori</em> eradication on chronicity of ITP in adult patients with ITP.<br> <span style="color:#008080;"><strong>Materials and Methods: </strong></span>Eighty five patients with acute ITP whose platelet count were less than 30x10⁹/L were enrolled to the study. Urea breath test (UBT) was carried out for all the patients and based on its results; the patients were divided into 3 groups: Group I: <em>H pylori</em> positive patients who underwent standard triple therapy. Evaluation of <em>H pylori</em> eradication for this group was carried out one month and six months after the treatment. Group II: ITP patients negative for <em>H pylori</em> and Group III: ITP patients&#39; positive for <em>H pylori</em> but without eradication therapy.<br> <span style="color:#008080;"><strong>Results:</strong> </span>52(61.2%) patients were female and 33(38.8%) were male with mean age of 34.8&plusmn;12.2 years. There was no significant difference between the mean age and gender in different groups. No significant difference was seen in mean platelet count at the baseline among the groups, but there was a significant statistical difference in mean platelet between the groups at the end of the first month. However, a significant difference was not seen in mean platelet count in months 2 to 6. Chronicity in group I was statistically less than the group III. Also, the chronicity rate in non-infected ITP patients was lower than the <em>H pylori</em> positive patients (P=0.03). Likewise, the chronicity rate was lower in the intervention group than in the control group (P=0.035).<br> <span style="color:#008080;"><strong>Conclusion:</strong> </span>Our results show that eradication of <em>H pylori</em> can reduce the chronicity rate in adult patients with ITP. Further studies on larger number of patients with longer follow-up are recommended.</span></span></p> Chronicity, Helicobacter pylori, Idiopathic Thrombocytopenic Purpura, Platelet, Urea breath test 1 7 http://journal.zums.ac.ir/browse.php?a_code=A-10-1-119&slc_lang=en&sid=1 Minoosh Moghimi 5200319475328460052954 5200319475328460052954 No Dept. of Internal Medicine,Vali-e-Asr Hospital, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Yousef Mortazavi youmort@yahoo.com 5200319475328460052955 5200319475328460052955 Yes Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Saeed Razavi-Dizaji 5200319475328460052956 5200319475328460052956 No Dept. of Internal Medicine,Vali-e-Asr Hospital, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Shahrbanoo Keyhanian 5200319475328460052957 5200319475328460052957 No Dept. of Internal Medicine, Faculty of Medicine, Azad University of Tonekabon, Tonekabon, Iran Zahra Ghadimi 5200319475328460052958 5200319475328460052958 No Dept. of Internal Medicine,Vali-e-Asr Hospital, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Sahar Baba Ali 5200319475328460052959 5200319475328460052959 No Dept. of Internal Medicine,Vali-e-Asr Hospital, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Saeideh Mazloomzadeh 5200319475328460052960 5200319475328460052960 No Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Sattar Jafari 5200319475328460052961 5200319475328460052961 No Dept. of Internal Medicine,Vali-e-Asr Hospital, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Reza Mansouri 5200319475328460052962 5200319475328460052962 No Dept. of Internal Medicine,Vali-e-Asr Hospital, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Masoud Asadi-Khiavi 5200319475328460052963 5200319475328460052963 No Dept. of Pharmacotherapy, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran