Journal of Advances in Medical and Biomedical Research

en The Effect of Open Lung Ventilation on Respiratory Mechanics, Postoperative Organ Function, and Inflammatory Mediators in Coronary Artery Bypass Surgery Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article Background and Objective: The present study aimed to assess the supportive role of open lung ventilation on respiratory mechanics, the rate of oxygenation, inflammatory biomarkers, and probable liver or renal injuries following coronary artery bypass grafting surgery. Materials and Methods: This randomized double-blinded clinical trial study was conducted on 64 candidates for coronary artery bypass surgery using a cardiopulmonary pump. The patients were randomly categorized into the Positive end-expiratory pressure (PEEP) group (n = 32) or Zero End Expiratory Pressure (ZEEP) group (n = 32). Results: Interleukin-6 levels were similar between the PEEP and ZEEP groups before surgery (p = 0.18) and were significantly higher in the ZEEP group after pump insertion (p = 0.005). On the contrary, the levels of Interleukin-6 were significantly higher in the PEEP group after extubation (p = 0.001). The Between-group analysis also showed a significant difference between the levels of interleukin-6 in the ZEEP and PEEP groups, representing a greater increase in the PEEP group (p < 0.001). There was no difference in certain hemodynamic parameters, including heart rate, mean blood pressure, mean CO2 pressure (PCO2), mean concentration of HCO3, and base excess. The mean arterial O2 saturation was higher overall in the PEEP group compared to the ZEEP group. The mean PaO2/FiO2 was significantly higher in the PEEP than in the ZEEP group (p < 0.001). Conclusion: Supportive ventilation technique leads to better oxygenation and better lung expansion, as well as lowering inflammatory biomarkers, after coronary artery bypass surgery. Coronary Artery Bypass, Pulmonary Ventilation, Interleukin-6, Positive-Pressure Respiration 12 16 http://journal.zums.ac.ir/browse.php?a_code=A-10-5633-1&slc_lang=en&sid=1 Saloomeh Sehat Kashani salume.sehat@gmail.com 5200319475328460066828 5200319475328460066828 No Dept. of Anesthesiology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Faranak Rokhtabnak rkhtbnk@yahoo.com 5200319475328460066829 5200319475328460066829 No Dept. of Anesthesiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran Mohammad Reza Ghodraty mrghodrati@yahoo.com 5200319475328460066830 5200319475328460066830 No Dept. of Anesthesiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran Mohammad Mahdi Zamani mmzses@gmail.com 5200319475328460066831 5200319475328460066831 No Dept. of Anesthesiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mehrdad Mesbah Kiaee drmmesbah@gmail.com 5200319475328460066832 5200319475328460066832 No Dept. of Anesthesiology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Masoud Ghorbanlo masoudghorbanlo@yahoo.com 5200319475328460066833 5200319475328460066833 No Dept. of Anesthesiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Shima Movassaghi Shima.movassaghi@gmail.com 5200319475328460066834 5200319475328460066834 No Dept. of Anesthesiology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Pooya Derakhshan pooyaderakh@yahoo.com 5200319475328460066835 5200319475328460066835 Yes Dept. of Anesthesiology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran