en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:16px;"><span style="color:#ffffff;"><strong><span style="background-color:#16a085;">Background and Objective</span></strong></span>: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Oxidative stress is one of the involved factors in CRC onset and progression<span dir="RTL">.</span> Recent examinations have revealed antioxidant characteristics of vitamin D. Given the vital role of this vitamin in balancing free radicals and antioxidant capacity, in this study we intended to review the association between vitamin D deficiency and oxidative stress in CRC patients.<span dir="RTL"></span><br> <strong><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span> </strong>In the present case-control study, 30 CRC patients and 32 healthy individuals were entered, based on the defined inclusion and exclusion criteria. Peripheral blood was taken from the subjects. Thiobarbituric acid reactive substance (TBARS) values, total antioxidant capacity, and serum vitamin D were measured. Data were interpreted using SPSS 18 software; t-test and the Mann Whitney test were applied.<br> <strong><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span> <span dir="RTL"></span></strong>The outcomes explained that TBARS values were significantly greater in patients group (P <0.005), but no meaningful difference was monitored in the total antioxidant capacity. 21 (70%) patients and 14 (44%) control subjects had inadequate vitamin D. There was a significant association between serum vitamin D in both groups (P <0.005). A notable negative relationship was found between vitamin D values and oxidative stress indicator (p=0.05, r =-0.249).<br> <span style="color:#ffffff;"><strong><span style="background-color:#16a085;">Conclusion:</span></strong></span>&nbsp;Insufficient vitamin D can lead to an increase in oxidative stress, which is directly associated with CRC. Serum vitamin D levels were also inadequate in high percentage of cancer patients. Given the predominance of vitamin D insufficiency in the population, more extensive studies are required to prove the impact of deficiency on disease pathogenesis.</span></span></p> Colorectal cancer, Vitamin D, Oxidative stress 352 358 http://journal.zums.ac.ir/browse.php?a_code=A-10-5657-1&slc_lang=en&sid=1 Hadis Musavi msc.musavi66@gmail.com 5200319475328460088891 5200319475328460088891 No Dept. of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Tayebeh Azramezani Kop somayehazramezani@yahoo.com 5200319475328460088892 5200319475328460088892 No Dept. of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Anahita Ebrahimpour anahita.ebrahimpour@gmail.com 5200319475328460088893 5200319475328460088893 No Dept. of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Setareh Rezatabar 3tareh.rezatabar1993@gmail.com 5200319475328460088894 5200319475328460088894 No Dept. of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Afsaneh Dashtaki afsaneh.dashtaki 2372@gmail.com 5200319475328460088895 5200319475328460088895 No Dept. of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Fatemeh Kalaki-Jouybari fatemeh.kalaki1991@gmail.com 5200319475328460088896 5200319475328460088896 No Dept. of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Masoumeh Karimi Karimirt@yahoo.com 5200319475328460088897 5200319475328460088897 No Dept.of Radiathion Oncology, Babol University of Medical Sciences, Babol, Iran Sohrab Halalkhor hallalkhorsohrab@gmail.com 5200319475328460088898 5200319475328460088898 Yes Dept. of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran