en Clinical Medicine Clinical Medicine کارآزمایی بالینی Clinical Trials <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="line-height:115%"><span style="line-height:115%">Oral mucositis (OM) is one of the most painful, and disabling oral inflammatory conditions caused by chemotherapy. This study aimed to determine the pomegranate seed oil (PSO) effect on improving chemotherapy-induced mucositis.</span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="line-height:115%"><span style="line-height:115%">This single-blind, randomized, clinical trial recruited patients with chemotherapy-induced mucositis in the oncology ward of Shahid Beheshti Hospital in Kashan, Iran, in 2018 (n = 70). Patients were divided into two groups by randomized block design. The control group was treated with 15 ml of routine mouthwash 4 times daily for 14 days. The intervention group was treated with mixed solution of routine mouthwash and PSO (50:50). The mucositis severity was evaluated on the 1st, 7th and 14th days after the intervention using a checklist for assessing the mucositis severity. Data were analyzed using Chi-square, Fisher&#39;s exact, independent t and repeated measures ANOVA tests.</span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="line-height:115%"><span style="line-height:115%">The subjects&rsquo; mean ages in the intervention and control groups were 57.48&plusmn;14.742 and 58.81&plusmn;14.134 years, respectively. Groups were matched for clinical and demographic characteristics (P>0.05). The mean mucositis severity in the intervention group decreased from 1.97 on the 1st day to 0.52 on the 7th day and to 0.03 on the 14th day (P<0.001). The rates of mucositis severity in the control group were 1.98, 1.47 and 0.63, respectively on these days (P<0.001).</span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="line-height:115%"><span style="line-height:115%">The mouthwash containing PSO improved chemotherapy-induced mucositis further than the routine mouthwash. Therefore, PSO can be used along with routine medicinal solutions to relieve and prevent oral mucositis symptoms.</span></span></span></span></p> Cancer, Chemotherapy, Oral mucositis, Pomegranate seed, Stomatitis 423 430 http://journal.zums.ac.ir/browse.php?a_code=A-10-5680-2&slc_lang=en&sid=1 Mohsen Taghadosi Taghadosi_1345@yahoo.com 5200319475328460073748 5200319475328460073748 No Trauma Nursing Research Center, Faculty of Nursing and Midwifery, Kashan University of Medical Sciences, Kashan, Iran Hossein Akbari akbari1350_h@yahoo.com 5200319475328460073749 5200319475328460073749 Yes Social Determinants of Health (SDH) Research Center, Kashan University of Medical Sciences, Kashan, Iran Fahimeh Ganjoori faganjori@gmail.com 5200319475328460073750 5200319475328460073750 No Dept. of Medical Surgical Nursing, Faculty of Nursing and Midwifery, Kashan University of Medical Sciences, Kashan, Iran Masoud Fakharian msdfakharian@yahoo.com 5200319475328460073751 5200319475328460073751 No Dept. of Cardiovascular Medicine, Kashan University of Medical Sciences, Kashan, Iran