Journal of Advances in Medical and Biomedical Research

en Association of Low Zinc Concentration and Hyperleptinemia with Overweight and Insulin Resistance in Polycystic Ovary Syndrome Women Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article Background and Objective: It has been reported that low concentration of zinc in serum is associated with insulin resistance (IR), also appears to be a relationship between insulin and leptin. In this study the possibility of increased leptin concentration and zinc deficiency was evaluated; in the following, their relationship with overweight and IR was investigated in women with polycystic ovary syndrome (PCOS). Materials and Methods: In this case-control study, 104 PCOS involved cases and 99 healthy individuals as control were included. Blood specimens were collected from participants post overnight fasting period; zinc concentrations (spectrophotometry method), leptin (ELISA method), insulin (ECLIA method), lipid profiles and glucose were measured with enzymatic method. The homeostasis model assessment (HOMA) index determined the IR level. Results: Zinc level was 87.20 ± 11.32 μg/dl in PCOS group, and 113.68 ± 8.31μg/dl in control group. Leptin  concentration was 23.06 ± 3.33 ng/mL and 19.37 ± 3.34 ng/mL, and IR was 2.37 ± 0.83 and 1.45 ± 0.74 in case and control groups, respectively (all p<0.001). Zinc had marked negative correlation with leptin, insulin, and IR (p<0.001). According to the subject, which waist circumference and body mass index (BMI) parameters were confounding factors, hyperleptinemia and zinc decrement significantly affected PCOS subjects. In contrast, only zinc decrement had an association with PCOS, after eliminating the confounding factors (OR: 0.782, p<0.001). Conclusion: Zinc reduction is more effective on PCOS than hyperleptinemia. Hyperleptinemia has association with waist circumference and BMI; it can also affect PCOS. Zinc, Leptin, Insulin resistance, Overweight, Polycystic ovary syndrome 116 122 http://journal.zums.ac.ir/browse.php?a_code=A-10-5603-3&slc_lang=en&sid=1 Sahar Mazloomi saharmazloomi1001@yahoo.com 5200319475328460073391 5200319475328460073391 No Dept. of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Zeinab Barartabar zeinabbarartabar@gmail.com 5200319475328460073392 5200319475328460073392 No Dept. of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Hiva Danesh hivadanesh@yahoo.com 5200319475328460073393 5200319475328460073393 No Dept. of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Narges Alizadeh nargesalizade4230@gmail.com 5200319475328460073394 5200319475328460073394 No Dept. of Obstetrics and Gynecology, Shariati Hospital, Alborz University of Medical Sciences, Alborz, Iran Shamim Pilehvari sh.pilehvari@yahoo.com 5200319475328460073395 5200319475328460073395 Yes Dept. of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran