en Medical Biology Medical Biology مقاله مروری Review Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong></span></span><span style="line-height:1;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><span style="line-height:2;">It has been reported that allopathic drugs do not have significant effects on diabetes treatment. In contemporary literature, much attention has been given to the potential use of traditional medicines, including medicinal plants, in the treatment of metabolic abnormalities. Indeed, the effect of <i>Securigera securidaca</i>, as a medicinal agent, in alleviating the complications of diabetes has received marked attention, particularly in animal models. The aim of this review is to clarify the <i>S.securidaca</i> therapeutic effects in diabetes mellitus treatment based on animal research.</span></span></span></span><br> <span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong></span></span><span style="line-height:2;"><span style="font-size:16px;"><span style="font-family:Times New Roman;">PubMed, Google Scholar, and the Web of Science were searched, from inception to January 2020 to investigate the effects of <i>S.securidaca</i> on diabetes in animal models. Each article was critically rewired for its methodological quality using the CAMARADE tool.</span></span></span><br> <span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;</span></span><span style="line-height:2;"><span style="font-size:16px;"><span style="font-family:Times New Roman;">Thirteen articles were reviewed and some positive effects of <i>S.securidaca</i> were observed in alloxan and Streptozotocin-induced diabetic animals. With a closer look at the mechanisms, <i>S.securidaca</i> is comparable with current antidiabetic drugs. The results of animal trials indicated hypoglycemic effects of <i>S.securidaca</i> in animal models.</span></span></span><br> <span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong></span></span><span style="line-height:2;"><span style="font-size:16px;"><span style="font-family:Times New Roman;">Remedies like <i>S.securidaca</i> could count as a treatment option for diabetic patients, alongside current antidiabetic medications, yet with fewer side-effects.</span></span></span></p> Securidaca, Diabetes Mellitus, Hypoglycemic Agents, Herbal Medicine 14 24 http://journal.zums.ac.ir/browse.php?a_code=A-10-5210-1&slc_lang=en&sid=1 Zahra Nasehi zahranasehi@hotmail.com 5200319475328460074748 5200319475328460074748 No Dept. of Clinical Biochemistry, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran Mohammad Esmaeil Shahaboddin shahaboddin.mohammad@gmail.com 5200319475328460074749 5200319475328460074749 No Biochemistry and Nutrition in Metabolic Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran Sadegh Jafarnejad drsadegh2008@gmail.com 5200319475328460074750 5200319475328460074750 Yes Biochemistry and Nutrition in Metabolic Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran