en Epidemiologic Studies Epidemiologic Studies مقاله مروری Review Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong>Vascular stenosis is one of the causes of cardiovascular diseases (CVDs). Implementing appropriate therapeutic measures for CVDs requires preventing the progression of stenosis. The purpose of this study was to evaluate the efficacy of atorvastatin and rosuvastatin on the levels of alpha and beta apolipoproteins using systematic review and meta-analysis.<br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="letter-spacing:-.1pt">This review was performed based on the PRISMA protocol. The ISI, Cochrane Library, Google Scholar, PubMed, and Scopus databases were independently searched by two researchers. MeSH keywords were used to recruit related articles published between 2005 and 2018. Meta-analysis was conducted in STATA 11.1software.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="letter-spacing:-.1pt">A total of 65 articles were found. Out of these, nine studies were ultimately included in meta-analysis. The findings showed that alpha lipoprotein level increased by 4.24 mg/dl (95% CI: -0.03; -8.45) and 8.71 mg/dl (95% CI: -1.95; -15.48) in patients treated with atorvastatin and rosuvastatin, respectively. Also, patients treated with either atorvastatin or rosuvastatin showed 40.55mg/dl (95% CI: 32.16; 45.93) and 44.78 g/dl (95% CI: 34.16; 55.39) decreases in beta-lipoprotein levels, respectively.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong>According to the results, rosuvastatin is more effective than atorvastatin in reducing alpha apolipoprotein and increasing beta apolipoprotein levels within a short period of time.</span></span></p> Atorvastatin, Rosuvastatin, Alphaapolipoprotein, Beta apolipoprotein, Systematic review, Meta-analysis 109 116 http://journal.zums.ac.ir/browse.php?a_code=A-10-1889-13&slc_lang=en&sid=1 Kourosh Sayehmiri sayehmiri@tums.ac.ir 5200319475328460075561 5200319475328460075561 No Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran Siros Norozi noroz_s@medilam.ac.ir 5200319475328460075562 5200319475328460075562 No Dept. of Cardiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Hamed Tavan hamedtavan@gmail.com 5200319475328460075563 5200319475328460075563 Yes Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran