Journal of Advances in Medical and Biomedical Research

en Age Related Changes in Indices of Bone Metabolism and Oxidative Stress in Postmenopausal Women in Southern Nigeria Life Science Life Science مقاله پژوهشی Original Research Article Background and Objective: Oxidative stress (OS) associated with estrogen deficiency in menopause has been implicated in various complications of menopause. Some indices of OS, bone metabolism and uric acid (UA) in postmenopausal women were assessed as possible predictors of gouty osteoarthritis. Materials and Methods: This case-control study enrolled 40 postmenopausal women and 60 premenopausal women as participants. The levels of reduced glutathione (GSH), nitric oxide (NO), total plasma peroxides (TPP), total antioxidant capacity (TAC), malondialdehyde (MDA), inorganic phosphate (Pi), total calcium (tCa) and UA were estimated by colorimetry, estradiol (E2) by ELISA and oxidative stress index (OSI) by calculation. Data were analyzed using t-test, correlation and regression at P<0.05. Results: Postmenopausal women had higher UA, OSI and lipid peroxidation (higher MDA, TPP) with lower E2, tCa and antioxidants (reduced GSH, NO, TAC) compared to premenopausal women (P<0.05). Aging correlated negatively with E2 (r=-0.273, P=0.006), TAC (r=-0.484, P=<0.001), GSH (r=-0.306, P=0.002), NO (r=-0.337, P=0.001), tCa (r=-0.571, P=<0.001) and positively with TPP (r=0.445, P=<0.001), OSI (r=0.454, P=<0.001), MDA (r=0.505, P=<0.001) and UA (r=0.441, P=<0.001) in all women studied irrespective of menopause status. There were no associations between UA, tCa, Pi, E2 and indices of oxidative stress (TPP, TAC, OSI, MDA, GSH, NO) with menopause (R2 =0.216, P=0.728). Conclusion: Elevated UA, lipid peroxidation and oxidative stress and reduced tCa, E2 and antioxidants observed in postmenopausal women may be associated with aging and not the menopausal status suggesting that their assessment may be utilized in predicting women at increased risk of gouty osteoarthritis. Menopause, Lipid peroxidation, Oxidative stress, Bone metabolism 125 132 http://journal.zums.ac.ir/browse.php?a_code=A-10-6240-2&slc_lang=en&sid=1 Augusta Chinyere Nsonwu-Anyanwu austadechic@yahoo.com 5200319475328460075570 5200319475328460075570 Yes Dept. of Clinical Chemistry & Immunology, University of Calabar, Nigeria Raymond Ekong Eworo raymondeworo@yahoo.com 5200319475328460075571 5200319475328460075571 No Dept. of Clinical Chemistry & Immunology, University of Calabar, Nigeria Magnus Chinonye Nsonwu magnusdegreat@yahoo.com 5200319475328460075572 5200319475328460075572 No Dept. of Optometry, Imo State University, Owerri, Nigeria Uwem Okon Akpan akpauwem11@gmail.com 5200319475328460075573 5200319475328460075573 No Dept. of Clinical Chemistry & Immunology, University of Calabar, Nigeria Faith Adamma Kalu faithkalu001@gmail.com 5200319475328460075574 5200319475328460075574 No Dept. of Clinical Chemistry & Immunology, University of Calabar, Nigeria Eberechi Ogbonna Nwevo ebydizzyx5@gmail.com 5200319475328460075575 5200319475328460075575 No Dept. of Clinical Chemistry & Immunology, University of Calabar, Nigeria