en Pharmacology Pharmacology مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong>Cardiovascular diseases are the most important causes of death worldwide. Atherosclerosis, as a common form of cardiovascular disease, tends to involve specific areas of the circulatory system. Boron has anti-inflammatory and antioxidant properties with potential beneficial effects. In this study, we investigated the effect of Boron on histopathological changes of atherosclerotic plaque and lipid profile in hyperlipidemic rabbits.<br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="letter-spacing:-.1pt">Male rabbits in five groups of control, sham, hyperlipidemia, treatment 1 and treatment 2 were fed on high fat diet (1% cholesterol). Treatment groups received Boron, 4 mg / kg, on the first and 20^th days of experiment. Animals&rsquo; weights were measured on days 1, 21 and 60. Plasma levels of Cholesterol, LDL, HDL and TG were measured by photometric method. After 60 days, Sudan IV staining method was used for macroscopic study. Hematoxylin-eosin and Masson&rsquo;s trichrome staining method were performed for quantitative analysis.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="letter-spacing:-.1pt">Animals in the control and sham groups showed no significant change in serum lipid profile with no atherosclerotic plaque in aortic vessels. In the hyperlipidemia group, significant alterations in lipid profile and presence of atheroma plaques were detected. In animals receiving Boron as a protective agent, atheroma plaques were significantly less (p <0.05). This was confirmed by quantitative analysis.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong>Boron ameliorates the development and progression of atherosclerotic plaques. Boron can be used alone or in combination with other drugs as anti-atherosclerotic treatment.</span></span></p> Atherosclerosis, Boron, Hyperlipidemia, Atheroma plaques, Lipid profile 197 203 http://journal.zums.ac.ir/browse.php?a_code=A-10-6277-1&slc_lang=en&sid=1 Robabeh Asadi sepidehasadi9473@gmail.com 5200319475328460075612 5200319475328460075612 No Dept. of Anatomy, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Javad Raouf Sarshoori raoufsar@gmail.com 5200319475328460075613 5200319475328460075613 Yes Dept. of Anatomy, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Maryam Ghorbani ghorbanimar@gmail.com 5200319475328460075614 5200319475328460075614 No Dept. of Pharmacology and Toxicology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran Mahmood Mofid mofidmmail@yahoo.com 5200319475328460075615 5200319475328460075615 No Dept. of Anatomy, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran