Journal of Advances in Medical and Biomedical Research

en Function Assessment of a Fabricated Artificial Vascular Graft in Sheep Carotid Artery Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article Background and Objective: In the field of vascular surgery, the use of tissue-engineered vascular grafts is advancing and new synthetic tissues are being utilized to replace damaged blood vessels. These synthetic vessels, made through tissue engineering techniques, must mimic the shape and mechanical properties of native vessels. This study was performed to assess the function of an artificial vascular graft in an animal model. Materials and Methods: The evaluation of artificial vessels was carried out on rat and sheep models. The artificial vascular scaffolds were made of Polyethylene terephthalate (PET), Polyurethane (PU), and Polycaprolactone (PCL) polymers. In the first phase, the fabricated scaffolds were implanted in rats and after 45 days, the grafts were removed and evaluated pathologically. In the second phase, the structures were implanted into the carotid arteries of sheep. Doppler ultrasound and angiography imaging were done to assess changes in carotid blood flow. Eleven months later, the artificial grafts and surrounding tissues were removed and evaluated pathologically. Results: In the rat samples, no hypodermic infections, systemic inflammation, or fibrosis of adjacent tissues were observed. In the sheep samples, no local or systemic complications were reported one week after surgery. No complications were seen after 11 months in the two sheep that received PCL/PU grafts. In contrast, ultrasound evaluation showed thrombosis in the two other sheep that received PET/PU/PCL grafts. Conclusion: This study shows that the implanted artificial vessel used in sheep carotid arteries has a favorable patency rate and satisfactory clinical results, and in terms of mechanical properties, it may be a good candidate for vascular replacement. Artificial Vessel, Vascular Graft, Carotid, Sheep, Polyurethane (PU), Polycaprolactone (PCL), Polyethylene Terephthalate (PET) 449 456 http://journal.zums.ac.ir/browse.php?a_code=A-10-6431-1&slc_lang=en&sid=1 Gholamhossein Kazemzadeh kazemzadeh.md@gmail.com 5200319475328460078813 5200319475328460078813 No Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Hosein Kazemi Mehrjerdi h-kazemi@um.ac.ir 5200319475328460078814 5200319475328460078814 No Dept. of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran Masoud Rajabioun ma.rajabioun@gmail.com 5200319475328460078815 5200319475328460078815 No Dept. of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran Seyed Ali Alamdaran AlamdaranA@mums.ac.ir 5200319475328460078816 5200319475328460078816 No Dept. of Radiology, Faculty of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran Davod Mohebbi-Kalhori davoodmk@eng.usb.ac.ir 5200319475328460078817 5200319475328460078817 No Dept. of Chemical Engineering, Faculty of Engineering, University of Sistan and Baluchestan, Zahedan, Iran Nafiseh Jirofti nafise.jirofti@gmail.com 5200319475328460078818 5200319475328460078818 No Dept. of Chemical Engineering, Faculty of Engineering, University of Sistan and Baluchestan, Zahedan, Iran Samaneh Abolbashari abolbasharis1@mums.ac.ir 5200319475328460078819 5200319475328460078819 No Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Reza Taheri taherir1@mums.ac.ir 5200319475328460078820 5200319475328460078820 Yes Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran