en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="line-height:200%"><span style="unicode-bidi:embed"><span style="line-height:200%">Based on literatures, the patients with essential tremor have a thinner Retinal Nerve Fiber Layer (RNFL) layer in Optical Coherence Tomography (OCT) imaging, compared to the healthy population. Thus, we decided to examine the ocular-neural state of patients with essential tremor, by examining RNFL and Retinal Ganglion Cell Layer (RGCL) in the OCT reports of patients referred to Hazrat Rasool Akram Hospital in the years 2020 to 2022.</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="line-height:200%"><span style="unicode-bidi:embed"><span style="line-height:200%">This research was implemented in the form of case-control study.50 patients were recruited into each group of tremor, and healthy controls. OCT parameters, including thickness of RNFL and RGCL were evaluated and recorded.</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="line-height:200%"><span style="unicode-bidi:embed"><span style="line-height:200%">The study findings revealed a significant difference in the mean superior, superior nasal, superior temporal sections of the right eye and superior temporal and inferior temporal regions of the left eye in RNFL between the control group and all patients (<i>P</i></span> <span style="line-height:200%">< 0.01). Moreover, the results showed that there was a significant difference in the GCL in superior 6 mm of the right and left eye between the control group, and all patients (<i>P</i> <0.01).</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="line-height:200%"><span style="unicode-bidi:embed"><span style="line-height:200%">Regarding the results this study, it seems that patients with essential tremor have a significant decrease in some RNFL and GCL factors compared to healthy people. However, the majority of variables examined from RNFL and GCL in our study did not show significant differences. Moreover, this thinning could be associated with the neurodegenerative nature of the disease.</span></span></span></span></span></p> Essential Tremor, Optical Coherence Tomography, Retinal Ganglion Cell Layer, Retinal Nerve Fiber Layer 441 448 http://journal.zums.ac.ir/browse.php?a_code=A-10-5267-4&slc_lang=en&sid=1 Seyedeh Mahnaz Nasiri mahnaznasiri4391@yahoo.com 5200319475328460078808 5200319475328460078808 No Dept. of Neurology, Rasool Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Seyed Amir Hassan Habibi Habibi.sah@iums.ac.ir 5200319475328460078809 5200319475328460078809 Yes Dept. of Neurology, Rasool Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mohammad Rohani mohammadroohani@gmail.com 5200319475328460078810 5200319475328460078810 No Dept. of Neurology, Rasool Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Ahad Sedaghat ahad_s2000@yahoo.com 5200319475328460078811 5200319475328460078811 No Dept. of Ophtalmology, Rasool Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Sepideh Goudarzi S-goudarzi@student.tums.ac.ir 5200319475328460078812 5200319475328460078812 No Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran