en Clinical Medicine Clinical Medicine کارآزمایی بالینی Clinical Trials <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><span style="line-height:200%"><strong>Background & Objective</strong>: Tympanoplasty is a widely performed surgical procedure for chronic otitis media (COM), and efforts are being made globally to establish standardized surgical techniques. This study sought to compare the postoperative outcomes of endoscopic and microscopic approaches in COM patients.</span><br> <span style="line-height:200%"><strong>Materials & Methods</strong>: This randomized clinical trial of an open-label design was performed on 34 patients who were candidates for tympanoplasty surgery due to chronic otitis media in Urmia Imam Khomeini hospital from April to December 2022. Patient allocation was performed by grouping participants according to odd or even numbers, with half assigned to the endoscopic group and the remaining half assigned to the microscopic group.&nbsp; Demographic data, pain severity, operation duration, and graft success rate preoperatively and 3 and 6 months postopera&shy;tively were evaluated. Independent samples t-test, Chi-square test, and SPSS version 21were used to analyze data. A P-value ˂0.05 was considered statistically significant.</span><br> <span style="line-height:200%"><strong>Results: No significant difference was reported</strong> in terms of pre and postoperative pure tone audiometry conditions between the two groups. Significantly lower operation time (65.83 &plusmn; 11.6 minutes) was reported in the endoscopic group compared to the microscopic group (P=0.001). The graft success rate in the microscopic and endoscopic groups was 77.8% and 75%, respectively, which was not statistically significantly different (<em>P</em> = 0.84). A significant difference was observed between microscopic and endoscopic groups in the pain score of patients immediately after surgery (5.66 &plusmn;18.1 and 3.75 &plusmn; 1, retrospectively) and one day after surgery (5.50 &plusmn; 1.9&nbsp; and 3.62 &plusmn; 0.95, respectively) (P < 0.001).</span><br> <span style="line-height:200%"><strong>Conclusion: </strong>Endoscopic tympanoplasty technique has demonstrated comparable efficacy in improving hearing loss as the conventional method. However, its advantages in terms of reduced operating time and postoperative pain suggest that it may emerge as the preferred approach for tympanoplasty surgery.</span></span></span></p> Tympanoplasty, Otitis media, Endoscopy, Microscopy 1 8 http://journal.zums.ac.ir/browse.php?a_code=A-10-6815-1&slc_lang=en&sid=1 Reza Samarei samareireza@gmail.com 5200319475328460080437 5200319475328460080437 Yes Dept. of Otorhinolaryngology and Head Neck Surgery, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Amirsam Roushani roshani.amir@gmail.com 5200319475328460080438 0009-0002-1443-0813 No Dept. of Otorhinolaryngology and Head Neck Surgery, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Amin Yousefnezhad yousefnezhad.a@gmail.com 5200319475328460080439 0009-0005-0146-1591 No Dept. of Otorhinolaryngology and Head Neck Surgery, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran