en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="line-height:normal">Algae phenolic extracts have received special attention because of their effective and efficient antioxidant properties and their obvious effects in inhibiting various diseases related to oxidative stress, such as cancer. This study aimed to document the phenolic extract of <i>Spirulina platensis</i> against cancer cell line SK-GT-4 and regular cell line HBL100.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="line-height:normal">Phenolic compounds were extracted from <i>S. platensis</i><i>,</i> and the extract was checked for its anticancer activity by MTT. The constituents of phenolic extract were analyzed using high-performance liquid chromatography (HPLC).</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="line-height:normal">The results showed that the half maximal inhibitory concentration value for Phenolic extract was 36.52 &micro;g/mL for 50% of cell death. HPLC analysis revealed that the compounds with possible therapeutic effects are gallic acid, ferulic acid, cinnamic acid, syringic acid, and vanillic acid, which have anticancer activity.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="line-height:normal">The results of this study point out that the <i>S. platensis</i> phenolic extract has anticancer potential, and the phytoconstituents contributed to the anticancer effects.</span></span></span></p> Anticancer, Apoptosis, HPLC, Phenolic compounds, SK-GT-4, Spirulina platensis 499 506 http://journal.zums.ac.ir/browse.php?a_code=A-10-6878-1&slc_lang=en&sid=1 Rasha Naser Al-Jabery rasha_na.ch@sci.utq.edu.iq 5200319475328460078844 5200319475328460078844 Yes Dept. of Chemistry, College of Science, University of Thi-Qar, Thi-Qar, Iraq Mohammed Ajah. Auda Mohammed.Auda@sci.utq.edu.iq 5200319475328460078845 5200319475328460078845 No Dept. of Chemistry, College of Science, University of Thi-Qar, Thi-Qar, Iraq Hussain Yosif Al-Rekabi Hussain.Yosif@sci.utq.edu.iq 5200319475328460078846 5200319475328460078846 No Technical Institute Al-Nassiriah, Southern Technical University, Thi-Qar, Iraq