Journal of Advances in Medical and Biomedical Research

en Serum Levels of Factor XIII, D-dimer, and Fibrinogen as A non-Invasive Diagnostic Biomarkers in Patients with Venous Thromboembolism Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article Background & Objective: Using new diagnostic methods to help quickly diagnose VTE disease is important. It is well known that treatment of VTE is based on radiological methods, but the main purpose of this research was to investigate the relationship between blood coagulation factor XIII( FXIII), D-dimer, and fibrinogen levels in patients with VTE.  Materials & Methods: Seventy patients initially suspected of having VTE were included and determined their D-dimer, fibrinogen, and (FXIII )levels. The diagnosis of VTE was based on the CT-Angiography. The blood samples were prepared from the patients during the first 6 hours of admission and before using anticoagulant. Results: The mean level of D-dimer in VTE patients was higher than those without VTE (1770± 764.49 vs. 430.66± 263.98ng / ml) (p <0.001). The mean factor XIII level in patients with VTE was significantly lower than those without VTE(55.03±13.61 vs. 88.57±18.14ng / ml) (p <0.001). The mean fibrinogen level in patients with VTE was significantly lower than in non-VTE patients (140.49± 36.03 vs. 214.69± 69.73 mg/dl) (p <0.001). The cut-off value of D-dimer was 500 ng/ml, and the sensitivity and specificity were 97% and 74%, respectively. The cut-off point of fibrinogen was 168 mg/dl, with a sensitivity of and a specificity of 77% and 77%, respectively. The cut-off point of XIII was 70 ng/ml, with a sensitivity of and specificity85% and 82%, respectively. Conclusion:  Our findings suggest that combined measurement of serum levels of D-dimer, factor XIII, and fibrinogen can be used to confirm clinical suspicion for VTE.   D-dimer, Fibrinogen, Factor XIII, Venous thromboembolism 341 349 http://journal.zums.ac.ir/browse.php?a_code=A-10-6136-2&slc_lang=en&sid=1 Mahmoud Monadi Dr.monadi@yahoo.com 5200319475328460086800 5200319475328460086800 Yes Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Mohammad Ranaee drm.ranaee55@gmail.com 5200319475328460086801 0009-0002-3155-0008 No Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Hossein Omranpour Bandpey nsm.hafezi@gmail.com 5200319475328460086802 5200319475328460086802 No Dept. of Internal Medicine, School of Medicine, Babol University of Medical Sciences, Babol, Iran Durdi Qujeq dqujeq@gmail.com 5200319475328460086803 5200319475328460086803 No Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran