en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><span style="line-height:150%"><b><span style="line-height:150%">Backgrounds and Aims: </span></b><span style="line-height:150%">Intestinal atresia stands as a prevalent cause of neonatal intestinal obstruction, necessitating surgical intervention. Given the susceptibility of these patients to complications and potential mortality, this study aims to explore the complications and outcomes associated with intestinal atresias.</span></span><br> <span style="line-height:150%"><b><span style="line-height:150%">Methods: </span></b><span style="line-height:150%">This retrospective cohort study encompassed 59 patients with intestinal atresia evaluated at Shahid Sadoughi Hospital in Yazd between 2016 and 2021. Demographic data, atresia location, concurrent anomalies, complications, and outcomes were documented and analyzed.</span></span><br> <span style="line-height:150%"><b><span style="line-height:150%">Results: </span></b><span style="line-height:150%">59 patients with intestinal atresia, 22 boys and 37 girls, with a mean gestational age of 36.23 &plusmn; 2.61 weeks, were evaluated.Duodenal atresia was present in 39%, jejunal atresia in 28.8%, ileal atresia in 8.5%, colonic atresia in 5.1%, and concurrent jejunal and ileal atresia in 18.6% of cases. The predominant associated anomaly was cardiac (39%). Post-surgery, oral feeding commenced on average by day 8, with a complete transition to enteral nutrition by day 21. Thirty-four neonates (57.6%) necessitated a central venous line for TPN administration, with an average parenteral nutrition duration of approximately 14 days. Early postoperative complications included apnea (32.2%), anastomotic leak (10.2%), sepsis (25.4%), and wound dehiscence and infection (5.1%). Short bowel syndrome developed in 15.3% post-treatment. Late complications involved cholestasis (20.3%), chronic diarrhea (10.2%), chronic constipation (3.4%), and adhesive bowel obstruction (23.7%). The mortality rate was 15.3%, with the highest mortality associated with duodenal atresia (44.4%).</span></span><br> <span style="line-height:150%"><b><span style="line-height:150%">Conclusion: </span></b><span style="line-height:150%">A comprehensive assessment for concurrent anomalies, prompt treatment, and suitable nutritional support prove instrumental in mitigating complications and mortality in patients with intestinal atresia.</span></span></span></span></p> Intestinal Atresia, Follow-up, Short Bowel Syndrome 68 72 http://journal.zums.ac.ir/browse.php?a_code=A-10-7121-1&slc_lang=en&sid=1 Seyed Reza Mirjalili dr_sr_mirjalili@yahoo.com 5200319475328460083002 5200319475328460083002 No Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Roohollah Edalatkhah drr.edalatkhah@gmail.com 5200319475328460083003 5200319475328460083003 Yes Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Abdolhamid Amouei ab.amooee@yahoo.com 5200319475328460083004 5200319475328460083004 No Department of Surgery, School of public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mahmood Noorishadkam Noorishadkam@ssu.ac.ir 5200319475328460083005 5200319475328460083005 No Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mohamad Hosein Lookzadeh Drlookzadeh@gmail.com 5200319475328460083006 5200319475328460083006 No Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mojtaba Ahmadi Bidakhavidi dr.mojtabaahmadi.b@gmail.com 5200319475328460083007 0009-0002-8847-8131 No Shahid Sadoughi University of Medical Sciences, Yazd, Iran