en Clinical Medicine Clinical Medicine نامه به سردبیر Letter to the Editor <span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><span style="font-size:9.0pt"><span style="color:black">Avicenna&#39;s historical insights on digestive health and dermatological symptoms&#39; interrelationship, mainly nocturnal itching, are examined here. In his Canon of Medicine, Avicenna explains a deep relationship between the digestive system and the skin, pointing out that effective waste elimination via the skin is vital for overall wellness. The discussion highlights the significant impact of nocturnal itching on patients with inflammatory skin conditions, such as atopic dermatitis, psoriasis, and chronic urticaria, in studying the roles of skin barrier function and hormonal fluctuations. Furthermore, modern scientific research on the gut-skin axis is integrated to illustrate the continued relevance of Avicenna&#39;s therapeutic recommendations, such as addressing internal imbalances, body cleansing, and topical therapies.</span></span></span></span><br> &nbsp; Urticaria, Persian Medicine, Itching, Avicenna 393 396 http://journal.zums.ac.ir/browse.php?a_code=A-10-7199-1&slc_lang=en&sid=1 Maryam Taghavi Shirazi mtaghavish@yahoo.com 5200319475328460082269 5200319475328460082269 Yes Sajjad Sadeghi Teboshefa@yahoo.com 5200319475328460082270 5200319475328460082270 No