en Medical Biology Medical Biology مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><b><span style="background:#2d7f8f"><span style="color:white">Background & Objective:</span></span><b> </b></b><span style="color:black">Bone morphogenetic protein-9 (BMP-9) plays a pivotal role in regulating obesity, glucose homeostasis, and complications of metabolic syndrome (MetS), particularly in the context of estrogen deficiency. The aim of this study was to investigate the effects of eight weeks of high-intensity interval training on BMP-9 levels, insulin resistance (HOMA-IR), lipid profile, body composition, and components of metabolic syndrome in ovariectomized Wistar rats.</span><br> <b><span style="background:#2d7f8f"><span style="color:white"><span style="letter-spacing:-.1pt">&nbsp;Materials & Methods:</span></span></span></b> <span style="color:black"><span style="letter-spacing:-.1pt">Twenty-one Wistar rats (200&ndash;220 g) were randomly assigned into three equal groups (n=7): ovariectomized sedentary (OVX+Sal), ovariectomized with HIIT (OVX+HIIT), and sham-operated (Sham). The HIIT group underwent eight weeks of training (three sessions/week). Body weight, BMI, waist circumference, visceral fat, lipid profile, HOMA-IR, and BMP-9 levels were measured 24 hours post-training.</span></span><br> <b><span lang="EN-IN"><span style="background:#2d7f8f"><span style="color:white">Results: </span></span></span>&nbsp;</b><span style="color:black"><span style="letter-spacing:-.1pt">Statistical analysis was performed using one-way ANOVA followed by Tukey&rsquo;s post hoc test, with significance set at P < 0.05. The HIIT intervention resulted in significant elevations in HDL and BMP-9 concentrations (P = 0.001) compared to the OVX+Sal group.</span></span><br> <b><span style="background:#2d7f8f"><span style="color:white">Conclusion: </span></span>&nbsp;</b><span style="color:black">HIIT attenuates components of MetS in ovariectomized rats by increasing BMP-9 levels and improving insulin sensitivity, thereby suggesting a potential role for exercise in managing postmenopausal metabolic health.</span></span></span></p> HIIT, HOMA-IR, Dyslipidemia, Metabolic Syndrome, Ovariectomy 76 84 http://journal.zums.ac.ir/browse.php?a_code=A-10-7297-1&slc_lang=en&sid=1 Parvin Babaei p_babaei@gums.ac.ir 5200319475328460088292 5200319475328460088292 No Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Sahar Falahati sfnikto6926@gmail.com 5200319475328460088293 0009-0003-8466-6546 No Department of Sport Physiology, Faculty of Educational Science and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran Arsalan Damirchi damirchi@guilan.ac.ir 5200319475328460088294 5200319475328460088294 No Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran Zeinab Bayat Zeinabbayat93@gmail.com 5200319475328460088295 5200319475328460088295 No Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Farnaz Seyfi-Skishahr f.seify@yahoo.com 5200319475328460088296 5200319475328460088296 Yes Department of Sport Physiology, Faculty of Educational Science and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran Fatemeh Sadeghi-Noghlebari f.sadeghi@gmail.com 5200319475328460088297 0009-0004-7071-6044 No Department of Sport Physiology, Faculty of Educational Science and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran Maghsoud Nabilpour nabilpour@yahoo.com 5200319475328460088298 5200319475328460088298 No Department of Sport Sciences, Faculty of Educational Sciences and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran