Journal of Advances in Medical and Biomedical Research
Journal of Advances in Medical and Biomedical Research
J Adv Med Biomed Res
Medical Sciences
http://journal.zums.ac.ir
52
journal52
1606-9366
2676-6264
10.30699/jambr
en
jalali
1404
9
1
gregorian
2025
12
1
33
162
online
1
fulltext
en
Genetic Insights Into Psoriasis Therapy: A Review of Polymorphisms in the Genes of Both TNF-α and the TNF Signaling Pathway on the Response to Anti-TNF-α
Clinical Medicine
Clinical Medicine
مقاله مروری
Review Article
<p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><span style="color:black">Tumor necrosis factor-alpha (TNF-α) inhibitors are widely used as first-line treatments for moderate to severe plaque psoriasis, yet clinical responses vary considerably among patients despite their overall safety and efficacy. Genetic factors that influence the effectiveness of biologic therapies may contribute to this variability. This review, conducted between May and June 2024 using the Google Scholar and PubMed databases, examined studies exploring associations between genetic polymorphisms in TNF-α and various genes within the TNF signaling pathway and patient responses to anti-TNF-α therapy. A total of 20 relevant studies were identified, assessing polymorphisms in TNF-α (−238/rs361525, −1031/rs1799964, −308/rs1800629, −857/rs1799724), TNF receptor genes such as TNFRSF1B (rs1061622), and additional related genes including TNFAIP3 (rs610604), IL1B (rs1143623 and rs1143627), FCGR2A (H131R/rs1801274), and FCGR3A (V158F/rs396991). Overall, these genetic variations demonstrate potential significance in modulating therapeutic responses to anti-TNF-α agents in psoriasis. However, inconsistencies across existing studies highlight the need for larger, multi-center investigations to confirm their clinical relevance and support the integration of genetic markers into personalized treatment strategies.</span></span></span></p>
Psoriasis, Tumor Necrosis Factor Inhibitors, Pharmacogenetics, Polymorphism, Genetic
1
12
http://journal.zums.ac.ir/browse.php?a_code=A-10-7400-1&slc_lang=en&sid=1
Abeer Kadhim
Jamaah
abeer.jomaa@copharm.uobaghdad.edu.iq
5200319475328460087518
0009-0005-2679-2477
Yes
Department of Clinical Pharmacy, College of Pharmacy, University of Baghdad, Baghdad, Iraq
Fadya Y.
AL-Hamadani
fadia.jassem@copharm.uobaghdad.edu.iq
5200319475328460087519
5200319475328460087519
No
Department of Clinical Pharmacy, College of Pharmacy, University of Baghdad, Baghdad, Iraq
Ali Fadhil
Al-Saadi
al_saadi1968@yahoo.com
5200319475328460087520
0009-0008-4313-112X
No
Dermatology and Venereology Center, Medical City, Baghdad, Iraq