en Health Improvement Strategies Health Improvement Strategies مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><b><span style="background:#2d7f8f"><span style="color:white">Background & Objective:</span></span><b> </b></b><span style="color:black">Myocardial infarction (MI), commonly known as a heart attack, refers to the irreversible necrosis of cardiac muscle cells due to insufficient oxygen delivery resulting from reduced or obstructed coronary blood flow. Severe myocardial cell loss is a major cause of mortality in MI patients. Inflammatory markers such as chemerin and resistin, alongside cardiac enzymes, may play a key role in MI diagnosis and monitoring. This study aimed to evaluate the clinical significance of inflammatory markers (chemerin and resistin) and cardiac enzymes, including lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase-MB (CK-MB), and cardiac troponin I, by assessing their serum levels in patients with myocardial infarction compared to healthy controls.</span><br> <b><span style="background:#2d7f8f"><span style="color:white"><span style="letter-spacing:-.1pt">&nbsp;Materials & Methods:</span></span></span></b> <span style="color:black"><span style="letter-spacing:-.1pt">A total of 120 subjects participated in this study. Sixty were MI patient&rsquo;s diagnosed based on clinical presentation, symptoms, and electrocardiogram (ECG) findings, with a mean age of 59.31 &plusmn; 1.64 years. The remaining 60 were healthy control subjects with a mean age of 37.30 &plusmn; 2.10 years. The study was conducted in the Cardiac Care Unit of Baqubah Teaching Hospital, Diyala Governorate, Iraq. Serum levels of chemerin, resistin, troponin I, LDH, CK-MB, and AST were measured and statistically analyzed.</span></span><br> <b><span lang="EN-IN"><span style="background:#2d7f8f"><span style="color:white">Results: </span></span></span>&nbsp;</b><span style="color:black"><span style="letter-spacing:-.1pt">This study was conducted in Cardiac Care Unit of Baqubah Teaching Hospital in Diyala governorate, Iraq. The study revealed a significant decrease (P < 0.001) in the serum levels of chemerin and resistin among MI patients compared to controls. Conversely, there was a significant increase (P < 0.001) in troponin I, LDH, CK-MB, and AST levels. Additionally, overweight MI patients exhibited significantly higher levels (P < 0.001) of troponin I, chemerin, and resistin compared with normal-weight MI patients.</span></span><br> <b><span style="background:#2d7f8f"><span style="color:white">Conclusion: </span></span>&nbsp;</b><span style="color:black">Chemerin and resistin levels significantly decreased following admission and treatment in MI patients, suggesting that these inflammatory markers may serve as potential indicators of therapeutic response in myocardial infarction management.</span></span></span></p> Chemerin, Resistin, Myocardial Infarction, Electrocardiogram 88 97 http://journal.zums.ac.ir/browse.php?a_code=A-10-7435-1&slc_lang=en&sid=1 Ali Adnan Saleh alooshaliadnan55@gmail.com 5200319475328460087612 0009-0008-9075-0409 Yes Department of Chemistry, College of Science, University of Diyala, Baquba, Diyala, Iraq Khalid Shaalan Sahab KhalidShaalan@gmail.com 5200319475328460087613 5200319475328460087613 No Department of Chemistry, College of Science, University of Diyala, Baquba, Diyala, Iraq