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Volume 10, Issue 39 (6-2002)
J Adv Med Biomed Res 2002, 10(39): 13-20 |
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Zamanipour S, Mortazavi Y, Kaviani S. Occupational Exposure To Benzene And Its Hematological Consequences. J Adv Med Biomed Res 2002; 10 (39) :13-20
URL: http://journal.zums.ac.ir/article-1-408-en.html
URL: http://journal.zums.ac.ir/article-1-408-en.html
Abstract: (151432 Views)
Background: Considering the myelotoxic and leukemogenic effects of benzene on humans and to determine the concentration of benzene vapors in work places this study was carried out in one of the benzene-producing factories in Isfahan, Iran.
Materials and Methods: In this case-control study, forty age and sex matched workers who were occupationally exposed to benzene and forty people who were not exposed to benzene were selected. Air sampling from workplaces was carried out based on NIOSH recommendations, and the samples were analyzed using gas chromatography equipment. Hematological parameters were measured using Sysmex hematology analyser. The differential distribution of leukocytes and alkaline phosphatase in granulocytes, and also nitroblue tetrazolium reduction (NBT) in neutrophils were evaluated by microscopic methods.
Results: Benzene concentration in some workplaces was higher than standard values (3.99 ppm vs.lppm). There was no statistically significant difference in non-hematological parameters such as age, length of service and smoking, and also in hematological indices between the two groups. However, mean Hct, leukocyte alkaline phosphatase (LAP), and NBT reduction were associated with a significant increase in exposed workers (P<0.05).
Conclusion: Increment in LAP activity and NBT reduction found in exposed workers in some workplaces may be due to neutrophilic lineage stimulation by benzene and its metabolites.
Materials and Methods: In this case-control study, forty age and sex matched workers who were occupationally exposed to benzene and forty people who were not exposed to benzene were selected. Air sampling from workplaces was carried out based on NIOSH recommendations, and the samples were analyzed using gas chromatography equipment. Hematological parameters were measured using Sysmex hematology analyser. The differential distribution of leukocytes and alkaline phosphatase in granulocytes, and also nitroblue tetrazolium reduction (NBT) in neutrophils were evaluated by microscopic methods.
Results: Benzene concentration in some workplaces was higher than standard values (3.99 ppm vs.lppm). There was no statistically significant difference in non-hematological parameters such as age, length of service and smoking, and also in hematological indices between the two groups. However, mean Hct, leukocyte alkaline phosphatase (LAP), and NBT reduction were associated with a significant increase in exposed workers (P<0.05).
Conclusion: Increment in LAP activity and NBT reduction found in exposed workers in some workplaces may be due to neutrophilic lineage stimulation by benzene and its metabolites.
Type of Study: Original Research Article |
Received: 2008/11/10 | Accepted: 2002/06/15 | Published: 2002/06/15
Received: 2008/11/10 | Accepted: 2002/06/15 | Published: 2002/06/15
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