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Volume 26, Issue 116 (7-2018)
J Adv Med Biomed Res 2018, 26(116): 48-60 |
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Zamani N, Moazedi A A, Adarinesh Khaki M R, Pourmehdi Boroujeni M. The Effect of Docosahexaenoic Acid on Spatial Learning and Memory in Adult Male Rats Model of Alzheimer's Disease. J Adv Med Biomed Res 2018; 26 (116) :48-60
URL: http://journal.zums.ac.ir/article-1-5088-en.html
URL: http://journal.zums.ac.ir/article-1-5088-en.html
Nastaran Zamani *1 
, Ahmad Ali Moazedi2 , MOhammad Reza Adarinesh Khaki3 , Mehdi Pourmehdi Boroujeni4
, Ahmad Ali Moazedi2 , MOhammad Reza Adarinesh Khaki3 , Mehdi Pourmehdi Boroujeni4
1- Dept. of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran. , Na_zamani2000@yahoo.com
2- Dept. of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
3- Cognitive Research Center, Kerman University of Medical Sciences Sciences, Kerman, Iran.
4- Dept. of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
2- Dept. of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
3- Cognitive Research Center, Kerman University of Medical Sciences Sciences, Kerman, Iran.
4- Dept. of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Abstract: (161856 Views)
Background and Objective: Docosahexaenoic acid (DHA) is the major polyunsaturated fatty acid in the brain and a structural component of neuronal membranes. The present study aimed to examine the effect of DHA on spatial learning and memory in an electrical obliteration of nucleus basalis magnocellularis (NBM) model of Alzheimer's disease.
Materials and Methods: In this study 56 adult male Wistar rats were divided into eight groups: control, lesion (which received bilateral electrical lesions of the NBM), sham (the electrode was entered into the NBM with no lesion), lesion + DHA (0.1, 1, 2.5 and 5 mg/kg; ip) and Vehicle (lesion + Sesame Oil 0.2mL). After one week, the rats were trained to perform the Y-maze task for five days. Twenty-five days after training, a retention test was performed to determine long-term memory.
Results: Bilateral NBM lesion reduced spatial learning in comparison with control and sham groups (P<0.001). No effect on spatial learning was seen in the vehicle group compared with the lesion group. Treatment with DHA in the following groups; lesion + DHA 1mg/kg (P<0.05), lesion + DHA 2.5mg/kg (P<0.01), lesion + DHA 5mg/kg (P<0.01), significantly improved spatial learning. Moreover, no significant difference was observed between the results on the 5th day of training and memory retention on the 30th day.
Conclusion: From the results of this study, it can be concluded that Docosahexaenoic acid improves spatial learning defects in an electrical lesion of NBM model of Alzheimer's disease in a dose-dependent manner.
Keywords: Docosahexaenoic acid, Spatial learning, Nucleus basalis of magnocellularis, Alzheimer’s disease
Type of Study: Clinical Trials |
Received: 2018/03/3 | Accepted: 2018/03/3 | Published: 2018/03/3
Received: 2018/03/3 | Accepted: 2018/03/3 | Published: 2018/03/3
References
1. Rabieia Z, Hojjati MR, Rafieian-Kopaeiaa M, Alibabaeia Z. Effect of Cyperus rotundus tubers ethanolic extract on learning and memory in animal model of Alzheimer. Biomedicine & Aging Pathology. 2013; 3: 185-91. [DOI:10.1016/j.biomag.2013.08.006]
2. Maczurek A, Hager K, Kenklies M, et al. Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Adv Drug Deliv Rev. 2008; 60: 1463-70. [DOI:10.1016/j.addr.2008.04.015] [PMID]
3. Rabiei Z, Asgharzadeh S, Bigdeli MR. Medicinal Herbs Effective in the Treatment of the Alzheimer's Disease. JBUMS. 2015; 16: 51-9.
4. Belkouch M, Hachem M, Elgot A, et al. The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer's disease. J Nutr Biochem. 2016; 38: 1-11. [DOI:10.1016/j.jnutbio.2016.03.002] [PMID]
5. Tanaka K, Farooqui AA, Siddiqi NJ, Alhomida AS, Ong WY. Effects of Docosahexaenoic Acid on Neurotransmission. Biomol Ther. 2012; 20: 152-7. [DOI:10.4062/biomolther.2012.20.2.152] [PMID] [PMCID]
6. Solfrizzi V, D'Introno A, Colacicco AM, et al. Circulating biomarkers of cognitive decline and dementia. Clinica Chimica Acta. 2006; 364: 91-112. [DOI:10.1016/j.cca.2005.06.015] [PMID]
7. Cunnane SC, Plourde M, Pifferi F, Bégin M, Féart C, Barberger-Gateau P. Fish, docosahexaenoic acid and Alzheimer's disease. Prog Lipid Res. 2009; 48: 239-56. [DOI:10.1016/j.plipres.2009.04.001] [PMID]
8. Calon F, Cole G. Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. Prostaglandins Leukot Essent Fatty Acids. 2007; 77: 287-93. [DOI:10.1016/j.plefa.2007.10.019] [PMID]
9. Hashimoto M, Hossain S. Neuroprotective and Ameliorative Actions of Polyunsaturated Fatty Acids Against Neuronal Diseases: Beneficial Effect of Docosahexaenoic Acid on Cognitive Decline in Alzheimer's Disease. J Pharmacol Sci. 2011; 116: 150-62. [DOI:10.1254/jphs.10R33FM]
10. Moreira P, Zhu X, Liu Q, et al. Compensatory responses induced by oxidative stress in Alzheimer disease. Biol Res. 2006; 39: 7-13. [DOI:10.4067/S0716-97602006000100002] [PMID]
11. Lauritzen I, Blondeau N, Heurteaux C, Widmann C, Romey G, Lazdunski M. Polyunsaturated fatty acids are potent neuroprotectors. EMBO J. 2000; 19: 1784-93. [DOI:10.1093/emboj/19.8.1784] [PMID] [PMCID]
12. Pan HC, Kao TK, Ou YC, et al. Protective effect of docosahexaenoic acid against brain injury in ischemic rats. J Nutr Biochem. 2009; 20: 715-25. [DOI:10.1016/j.jnutbio.2008.06.014] [PMID]
13. Berman DR, Liu YQ, Barks J, Mozurkewich E. Docosahexaenoic acid confers neuroprotection in a rat model of perinatal hypoxia-ischemia potentiated by Escherichia coli lipopolysaccharide-induced systemic inflammation. Am J Obstet Gynecol. 2010; 202: 469. e1-6. [DOI:10.1016/j.ajog.2010.01.076] [PMID] [PMCID]
14. Ashkavandi S, Moazedi AA, Semnanian S, Eshagh-Harooni H, Mohammadi T, Pourmehdi-Boroujeni M. The effect of methylprednisolone on spatial learning and memory in adult male rats using an experimental model of Alzheimer's disease. Feyz. 2015; 19: 102-10.
15. Hoveida R, Moazedi AA, Rasekh AR. The effect of intra-Hippocampal CA1 area injection of Estradiol Benzoate on the spatial learning and memory in adult male rats. Modares J Med Sci. 2005; 7: 115-24.
16. Abraham IM, Koszegi Z, Tolod-Kemp E, Szego EM. Action of estrogen on survival of basal forebrain cholinergic neurons: Promoting amelioration. Psychoneuroendocrinology. 2009; 1: S104-12. [DOI:10.1016/j.psyneuen.2009.05.024] [PMID]
17. Zahedi M, Hojjati MR, Fathpour H, Rabiei Z, Alibabaei Z, Basim A. Effect of Rheum Ribes Hydro-Alcoholic Extract on Memory Impairments in Rat Model of Alzheimers Disease. Iran J Pharm Res. 2015; 14: 1197-206.
18. Dabir N, Moazedi AA, Haghparast A, Khajepour L, Akhoond M. Effects
19. of Estrogen Therapy on Cognitive Performance Deficit Induced by Nucleus Basalis Magnocellularis Lesion: Animal Model of Alzheimer's Disease. J Isfahan Med Sch. 2016; 34: 1-10.
20. Goshadrou F. Modified sensory processing in the barrel cortex of the Rat model of Alzheimer's disease. J Gorgan Uni Med Sci. 2011; 13: 16-25.
21. Figueroa JD, Cordero K, Baldeosingh K, et al. Docosahexaenoic acid pretreatment confers protection and functional improvements after acute spinal cord injury in adult rats. J Neurotrauma. 2012; 29: 551-66. [DOI:10.1089/neu.2011.2141] [PMID] [PMCID]
22. Hong SH, Belayev L, Khoutorova L, Obenaus A, Bazan NG. Docosahexaenoic acid confers enduring neuroprotection in experimental stroke. J Neurol Sci. 2014; 338: 135-41. [DOI:10.1016/j.jns.2013.12.033] [PMID] [PMCID]
23. Berman DR, Mozurkewich E, Liu Y, Barks J. Docosahexaenoic acid pretreatment confers neuroprotection in a rat model of perinatal cerebral hypoxia-ischemia. Am J Obstet Gynecol. 2009; 200: 305. e1-6. [DOI:10.1016/j.ajog.2009.01.020] [PMID] [PMCID]
24. Palacios-Pelaez R, Lukiw WJ, Bazan NG. Omega-3 essential fatty acids modulate initiation and progression of neurodegenerative disease. Mol Neurobiol. 2010; 41: 367-74. [DOI:10.1007/s12035-010-8139-z] [PMID]
25. Jiang LH, Shi Y, Wang LS, Yang ZR. The influence of orally administered docosahexaenoic acid on cognitive ability in aged mice. J Nutr Biochem. 2009; 20: 735-41. [DOI:10.1016/j.jnutbio.2008.07.003] [PMID]
26. Kim HY, Spector AA, Xiong ZM. A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. Prostaglandins Other Lipid Mediat. 2011; 96: 114-20. [DOI:10.1016/j.prostaglandins.2011.07.002] [PMID] [PMCID]
27. Hashimoto M, Hossain S, Shimada T, et al. Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats. J Neurochem. 2002; 81: 1084-91. [DOI:10.1046/j.1471-4159.2002.00905.x] [PMID]
28. Robson LG, Dyall S, Sidloff D, Michael-Titus AT. Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals. Neurobiol Aging. 2010; 31: 678-87. [DOI:10.1016/j.neurobiolaging.2008.05.027] [PMID]
29. Calderon F, Kim HY. Docosahexaenoic acid promotes neurite growth in hippocampal neurons. J Neurochem. 2004; 90: 979-88. [DOI:10.1111/j.1471-4159.2004.02520.x] [PMID]
30. de Wilde MC, Penke B, van der Beek EM, Kuipers AA, Kamphuis PJ, Broersen LM. Neuroprotective effects of a specific multi-nutrient intervention against Aβ42-induced toxicity in rats. J Alzheimers Dis. 2011; 27: 327-39. [DOI:10.3233/JAD-2011-110635] [PMID]
31. Favreliere S, Perault MC, Huguet F, et al. DHA-enriched phospholipid diets modulate age-related alterations in rat hippocampus. Neurobiol Aging. 2003; 24: 233-43. [DOI:10.1016/S0197-4580(02)00064-7]
32. Högyes E, Nyakas C, Kiliaan A, Farkas T, Penke B, Luiten PG. Neuroprotective effect of developmental docosahexaenoic acid supplement against excitotoxic brain damage in infant rats. Neuroscience. 2003; 119: 999-1012. [DOI:10.1016/S0306-4522(03)00198-2]
33. Nishikawa M, Kimura S, Akaike N. Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate responses in pyramidal neurons of rat cerebral cortex. J Physiol. 1994; 475: 83-93. [DOI:10.1113/jphysiol.1994.sp020051] [PMID]
34. Hamano H, Nabekura J, Nishikawa M, Ogawa T. Docosahexaenoic acid reduces GABA response in substantia nigra neuron of rat. J Neurophysiol. 1996; 75: 1264-70. [DOI:10.1152/jn.1996.75.3.1264] [PMID]
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