یکشنبه 2 دی 1403
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دوره 30، شماره 138 - ( 10-1400 )
جلد 30 شماره 138 صفحات 23-17 |
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Mosayebi Z, Mirzaaghayan M, Zeinaloo A, Gharib B, Ghahremani P. Vitamin D Status in Neonates with Congenital Heart Disease: Its Changes after Heart Surgery and Relationship to the Outcome. J Adv Med Biomed Res 2022; 30 (138) :17-23
URL: http://journal.zums.ac.ir/article-1-5956-fa.html
URL: http://journal.zums.ac.ir/article-1-5956-fa.html
Vitamin D Status in Neonates with Congenital Heart Disease: Its Changes after Heart Surgery and Relationship to the Outcome. Journal of Advances in Medical and Biomedical Research. 1400; 30 (138) :17-23
چکیده: (110417 مشاهده)
Background and Objective: Vitamin D deficiency has been implicated in a wide range of conditions such as infectious and autoimmune diseases, cardiovascular and cerebrovascular events, and various malignancies to unfavorable birth outcomes. We studied vitamin D status in a group of neonates with congenital heart disease (CHD) and its relationship with the outcome of heart surgery.
Materials and Methods: Total vitamin D levels in plasma were measured before and 24 hours after the operation in 45 neonates with CHD undergoing heart surgery and in 77 hospitalized neonates without a history of CHD as controls, at Children’s Medical Center between March and September 2018.
Results: Preoperative vitamin D levels in patients with CHD were not significantly different from the control group (42.4 +/- 18.0 versus 46.9 +/- 27.7 nmol/L, P=0.640). Patients’ vitamin D levels decreased postoperatively (42.4 +/- 18.0 versus 36.2 +/- 14.5 nmol/L, P=0.013). This decline was significant in the cyanotic and open-heart surgery groups, but not in non-cyanotic or closed-heart surgery groups. In 41 (91.1%) patients, the outcome was successful discharge from the hospital, in 3 (6.7%), the outcome was demise, and in one, it was not determined due to early discharge. Preoperative and postoperative vitamin D levels did not show any relationship with the outcome. However, logistic regression analysis revealed a significant relationship between the amount of postoperative decline in vitamin D levels and the outcome of death (OR=1.261, 95% CI=1.026-1.551, P=0.028).
Conclusion: Results corroborates previous findings and suggests the amount of postoperative decline in vitamin D levels as a predictor of the outcome of heart surgery in CHD.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Clinical medicine
دریافت: 1399/1/7 | پذیرش: 1399/11/20 | انتشار: 1400/7/25
دریافت: 1399/1/7 | پذیرش: 1399/11/20 | انتشار: 1400/7/25
فهرست منابع
1. Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiol Rev. 2016;96(1):365-408. [DOI:10.1152/physrev.00014.2015] [PMID] [PMCID]
2. McNally JD, Amrein K. Vitamin D Deficiency in Pediatric Critical Care. J Pediatr Intensive Care. 2016;5(4):142-53. [DOI:10.1055/s-0036-1583285] [PMID] [PMCID]
3. Caprio M, Infante M, Calanchini M, Mammi C, Fabbri A. Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects. Eat Weight Disord. 2017;22(1):27-41. [DOI:10.1007/s40519-016-0312-6] [PMID]
4. Gaksch M, Jorde R, Grimnes G, Joakimsen R, Schirmer H, Wilsgaard T, et al. Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium. PloS one. 2017;12(2):e0170791.
5. Hewison M, Wagner CL, Hollis BW. Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth. N Engl J Med. 2018;379(19):1880-1. [DOI:10.1056/NEJMc1812157]
6. Pludowski P, Grant WB, Konstantynowicz J, Holick MF. Editorial: Classic and Pleiotropic Actions of Vitamin D. Front Endocrinol. 2019;10:341. [DOI:10.3389/fendo.2019.00341] [PMID] [PMCID]
7. Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev. 2013;12(10):976-89. [DOI:10.1016/j.autrev.2013.02.004] [PMID]
8. Souberbielle JC, Body JJ, Lappe JM, Plebani M, Shoenfeld Y, Wang TJ, et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice. Autoimmun Rev. 2010;9(11):709-15. [DOI:10.1016/j.autrev.2010.06.009] [PMID]
9. Lee P, Nair P, Eisman JA, Center JR. Vitamin D deficiency in the intensive care unit: an invisible accomplice to morbidity and mortality? Intensive Care Med. 2009;35(12):2028-32. [DOI:10.1007/s00134-009-1642-x] [PMID]
10. de Haan K, Groeneveld AB, de Geus HR, Egal M, Struijs A. Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and meta-analysis. Crit Care. 2014;18(6):660. [DOI:10.1186/s13054-014-0660-4] [PMID] [PMCID]
11. Zajic P, Amrein K. Vitamin D deficiency in the ICU: a systematic review. Minerva Endocrinol. 2014;39(4):275-87.
12. Zhang YP, Wan YD, Sun TW, Kan QC, Wang LX. Association between vitamin D deficiency and mortality in critically ill adult patients: a meta-analysis of cohort studies. Crit Care. 2014;18(6):684. [DOI:10.1186/s13054-014-0684-9] [PMID] [PMCID]
13. Amrein K, Schnedl C, Holl A, Riedl R, Christopher KB, Pachler C, et al. Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. Jama. 2014;312(15):1520-30. [DOI:10.1001/jama.2014.13204] [PMID]
14. Amrein K, Sourij H, Wagner G, Holl A, Pieber TR, Smolle KH, et al. Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: a randomized, double-blind, placebo-controlled pilot study. Crit Care. 2011;15(2):R104. [DOI:10.1186/cc10120] [PMID] [PMCID]
15. Han JE, Jones JL, Tangpricha V, Brown MA, Brown LAS, Hao L, et al. High Dose Vitamin D Administration in Ventilated Intensive Care Unit Patients: A Pilot Double Blind Randomized Controlled Trial. J Clin Transl Endocrinol. 2016;4:59-65. [DOI:10.1016/j.jcte.2016.04.004] [PMID] [PMCID]
16. Nair P, Venkatesh B, Lee P, Kerr S, Hoechter DJ, Dimeski G, et al. A Randomized Study of a Single Dose of Intramuscular Cholecalciferol in Critically Ill Adults. Crit Care Med. 2015;43(11):2313-20. [DOI:10.1097/CCM.0000000000001201] [PMID]
17. Madden K, Feldman HA, Smith EM, Gordon CM, Keisling SM, Sullivan RM, et al. Vitamin D deficiency in critically ill children. Pediatrics. 2012;130(3):421-8. [DOI:10.1542/peds.2011-3328] [PMID] [PMCID]
18. Rippel C, South M, Butt WW, Shekerdemian LS. Vitamin D status in critically ill children. Intensive Care Med. 2012;38(12):2055-62. [DOI:10.1007/s00134-012-2718-6] [PMID]
19. Ayulo M, Jr., Katyal C, Agarwal C, Sweberg T, Rastogi D, Markowitz M, et al. The prevalence of vitamin D deficiency and its relationship with disease severity in an urban pediatric critical care unit. Endocr Regul. 2014;48(2):69-76. [DOI:10.4149/endo_2014_02_69] [PMID]
20. Hebbar KB, Wittkamp M, Alvarez JA, McCracken CE, Tangpricha V. Vitamin D Deficiency in Pediatric Critical Illness. J Clin Transl Endocrinol. 2014;1(4):170-5. [DOI:10.1016/j.jcte.2014.09.002] [PMID] [PMCID]
21. McNally JD, Menon K, Chakraborty P, Fisher L, Williams KA, Al-Dirbashi OY, et al. The association of vitamin D status with pediatric critical illness. Pediatrics. 2012;130(3):429-36. [DOI:10.1542/peds.2011-3059] [PMID]
22. McNally JD, Menon K, Lawson ML, Williams K, Doherty DR. 1,25-Dihydroxyvitamin D Levels in Pediatric Intensive Care Units: Risk Factors and Association With Clinical Course. J Clin Endocrinol Metab. 2015;100(8):2942-5. [DOI:10.1210/jc.2014-4471] [PMID]
23. Onwuneme C, Carroll A, Doherty D, Bruell H, Segurado R, Kilbane M, et al. Inadequate vitamin D levels are associated with culture positive sepsis and poor outcomes in paediatric intensive care. Acta Paediatr. 2015;104(10):e433-8. [DOI:10.1111/apa.13090] [PMID]
24. McNally JD, Nama N, O'Hearn K, Sampson M, Amrein K, Iliriani K, et al. Vitamin D deficiency in critically ill children: a systematic review and meta-analysis. Crit Care. 2017;21(1):287. [DOI:10.1186/s13054-017-1875-y] [PMID] [PMCID]
25. McNally JD, Menon K, Chakraborty P, Fisher L, Williams KA, Al-Dirbashi OY, et al. Impact of anesthesia and surgery fo congenital heart disease on the vitamin d status of infants and children: a prospective longitudinal study. Anesthesiology. 2013;119(1):71-80. [DOI:10.1097/ALN.0b013e31828ce817] [PMID]
26. Graham EM, Taylor SN, Zyblewski SC, Wolf B, Bradley SM, Hollis BW, et al. Vitamin D status in neonates undergoing cardiac operations: relationship to cardiopulmonary bypass and association with outcomes. J Pediatr 2013;162(4):823-6. [DOI:10.1016/j.jpeds.2012.10.013] [PMID] [PMCID]
27. Abou Zahr R, Faustino EVS, Carpenter T, Kirshbom P, Hall EK, Fahey JT, et al. Vitamin D Status After Cardiopulmonary Bypass in Children With Congenital Heart Disease. J Intensive Care Med. 2017;32(8):508-13. [DOI:10.1177/0885066616652077] [PMID]
28. Dohain AM, Almogati J, Al-Radi OO, Elassal AA, Zaher ZF, Fatani TH, et al. Serum vitamin D status following pediatric cardiac surgery and association with clinical outcome. Eur J Pediatr 2020;179(4):635-43. [DOI:10.1007/s00431-019-03538-x] [PMID]
29. Wagner CL, Greer FR. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008;122(5):1142-52. [DOI:10.1542/peds.2008-1862] [PMID]
30. McNally JD, O'Hearn K, Lawson ML, Maharajh G, Geier P, Weiler H, et al. Prevention of vitamin D deficiency in children following cardiac surgery: study protocol for a randomized controlled trial. Trials. 2015;16:402. [DOI:10.1186/s13063-015-0922-8] [PMID] [PMCID]
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