یکشنبه 2 دی 1403
[Archive]
دوره 30، شماره 138 - ( 10-1400 )
جلد 30 شماره 138 صفحات 46-39 |
برگشت به فهرست نسخه ها
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Keshavarzi Z, Safari F, Alipour B, Khoshniat A, Azizi R, Vatanchian M et al . Antioxidant Effects of Methanol Extract of Dracocephalum kotschyi in Acetic Acid Induced Rat Colitis Model. J Adv Med Biomed Res 2022; 30 (138) :39-46
URL: http://journal.zums.ac.ir/article-1-6258-fa.html
URL: http://journal.zums.ac.ir/article-1-6258-fa.html
Antioxidant Effects of Methanol Extract of Dracocephalum kotschyi in Acetic Acid Induced Rat Colitis Model. Journal of Advances in Medical and Biomedical Research. 1400; 30 (138) :39-46
چکیده: (112088 مشاهده)
Background and Objective: There is a worldwide trend towards substitute synthetic antioxidants with natural alternatives to treat inflammatory bowel disease (IBD) such as ulcerative colitis (UC). This study was conducted to evaluate the effects of Dracocephalum kotschyi extract on tissue injury and oxidative stress in an acetic-acid induced colitis model.
Materials and Methods: 48 male Wistar rats were allocated to 6 groups: healthy control, colitis control, and 4 treatment groups which administrated 10, 25, and 50 mg/kg of D. kotschyi extract respectively, and 200 mg/kg sulfasalazine once daily for 8 days after colitis induced. Colitis severity was assessed using histologic and macroscopic changes of damaged colon, and enzymatic antioxidant activities like superoxide dismutase (SOD), total thiol (–SH), superoxide dismutase (SOD), and lipid peroxidation marker MDA (malondialdehyde) were evaluated.
Results: D. kotschyi extract (50mg/kg) decreased colonic macroscopic and histological damage scores, which were accompanied by a significant decrease in lipid peroxidation, and an increase in colonic antioxidant markers.
Conclusion: The results suggest that D. kotschyi extract is effective against oxidative bowel damages induced in IBD and its beneficial effect is, at least in part, due to its antioxidant properties.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Clinical medicine
دریافت: 1399/7/21 | پذیرش: 1399/11/6 | انتشار: 1400/7/25
دریافت: 1399/7/21 | پذیرش: 1399/11/6 | انتشار: 1400/7/25
فهرست منابع
1. Colitis-Pathophysiology U. Inflammatory bowel disease part I: ulcerative colitis-pathophysiology and conventional and alternative treatment options. Altern Med Rev. 2003;8(3):247-83.
2. Podolsky DK. Inflammatory bowel disease. N Engl J Med. 1991;325(14):1008-16. [DOI:10.1056/NEJM199110033251406] [PMID]
3. Lih-Brody L, Powell SR, Collier KP, Reddy GM, Cerchia R, Kahn E, et al. Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease. Dig Dis Sci. 1996;41(10):2078-86. [DOI:10.1007/BF02093613] [PMID]
4. Zhou G, Yu L, Fang L, Yang W, Yu T, Miao Y, et al. CD177+ neutrophils as functionally activated neutrophils negatively regulate IBD. Gut. 2018;67(6):1052-63. [DOI:10.1136/gutjnl-2016-313535] [PMID]
5. Mulder T, Verspaget H, Janssens A, De Bruin P, Pena A, Lamers C. Decrease in two intestinal copper/zinc containing proteins with antioxidant function in inflammatory bowel disease. Gut. 1991;32(10):1146. [DOI:10.1136/gut.32.10.1146] [PMID] [PMCID]
6. Mirheidar H. Knowledge of plants. Amir kabir, Tehran. 1995.
7. Naghibi F, Mosaddegh M, Mohammadi Motamed M, Ghorbani A. Labiatae family in folk medicine in Iran: from ethnobotany to pharmacology. IJPR. 2010:63-79.
8. Yaghmai MS, Taffazoli R. The essential oil of Dracocephalum kotschyi Boiss. Flavour Fragr J. 1988;3(1):33-6. [DOI:10.1002/ffj.2730030107]
9. Kamali M, Khosroyar S, Mohammadi A. Antibacterial activity of various extracts from Dracocephalum kotschyi against food pathogenic microorganisms. Int J Pharmtech Res. 2015;8(9):158-63.
10. Amirghofran Z, Azadbakht M, Karimi MH. Evaluation of the immunomodulatory effects of five herbal plants. J Ethnopharmacol. 2000;72(1):167-72. [DOI:10.1016/S0378-8741(00)00234-8]
11. Golshani S, Karamkhani F, Monsef-Esfehani HR, Abdollahi M. Antinociceptive effects of the essential oil of Dracocephalum kotschyi in the mouse writhing test. J Pharm Sci. 2004;7:76-9.
12. Jahaniani F, Ebrahimi SA, Rahbar-Roshandel N, Mahmoudian M. Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. Phytochemistry. 2005;66(13):1581-92. [DOI:10.1016/j.phytochem.2005.04.035] [PMID]
13. Park CM, Jin K-S, Cho CW, Lee Y-W, Huh G-H, Cha Y-S, et al. Luteolin inhibits inflammatory responses by downregulating the JNK, NF-κB, and AP-1 pathways in TNF-α activated HepG2 cells. Food Sci Biotechnol. 2012;21(1):279-83. [DOI:10.1007/s10068-012-0037-x]
14. Jang S, Kelley KW, Johnson RW. Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. PANS. 2008;105(21):7534-9. [DOI:10.1073/pnas.0802865105] [PMID] [PMCID]
15. MacPherson B, Pfeiffer C. Experimental production of diffuse colitis in rats. Digestion. 1978;17(2):135-50. [DOI:10.1159/000198104] [PMID]
16. El-Naggar ME, Hussein J, El-sayed SM, Youssef AM, El Bana M, Latif YA, et al. Protective effect of the functional yogurt based on Malva parviflora leaves extract nanoemulsion on acetic acid-induced ulcerative colitis in rats. JMRT. 2020;9(6):14500-8. [DOI:10.1016/j.jmrt.2020.10.047]
17. Langmead L, Dawson C, Hawkins C, Banna N, Loo S, Rampton D. Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study. Aliment Pharmacol Ther. 2002;16(2):197-205. [DOI:10.1046/j.1365-2036.2002.01157.x] [PMID]
18. Keshavarzi Z, Nurmohammadi F, Majlesi S, Maghool F. Protective effects of walnut extract against oxidative damage in acetic acid-induced experimental colitis rats. Physiology and Pharmacology. 2019;23(1):51-8.
19. Keshavarzian A, Sedghi S, Kanofsky J, List T, Robinson C, Ibrahim C, et al. Excessive production of reactive oxygen metabolites by inflamed colon: analysis by chemiluminescence probe. Gastroenterology. 1992;103(1):177-85. [DOI:10.1016/0016-5085(92)91111-G]
20. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351-8. [DOI:10.1016/0003-2697(79)90738-3]
21. Alikhani V, Keshavarzi Z, Hadjzadeh MAR, Karimi S. The Effect of Melatonin on Gastric Parameters Following Diabetes Induction in Male Rats. Acta Endocrinol (Copenh). 2015;11(2). [DOI:10.4183/aeb.2015.155]
22. Carty E, De Brabander M, Feakins R, Rampton D. Measurement of in vivo rectal mucosal cytokine and eicosanoid production in ulcerative colitis using filter paper. Gut. 2000;46(4):487-92. [DOI:10.1136/gut.46.4.487] [PMID] [PMCID]
23. Blau S, Rubinstein A, Bass P, Singaram C, Kohen R. Differences in the reducing power along the rat GI tract: lower antioxidant capacity of the colon. Mol Cell Biochem. 1999;194(1-2):185-91. [DOI:10.1023/A:1006994800272] [PMID]
24. Harisa GEI, Abo-Salem OM, El-Sayed E-SM, Taha EI, El-Halawany N. L-arginine augments the antioxidant effect of garlic against acetic acid-induced ulcerative colitis in rats. Pak J Pharm Sci. 2009;22(4).
25. Hagar HH, El Medany A, El Eter E, Arafa M. Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats. Eur J Pharmacol. 2007;554(1):69-77. [DOI:10.1016/j.ejphar.2006.09.066] [PMID]
26. Del Maestro R. An approach to free radicals in medicine and biology. Acta Physiol Scand Suppl. 1980;492:153-68.
27. Guan G, Lan S. Implications of antioxidant systems in inflammatory bowel disease. Biomed Res Int. 2018;2018. [DOI:10.1155/2018/1290179] [PMID] [PMCID]
28. Biswas S, Das R, Banerjee ER. Role of free radicals in human inflammatory diseases. AIMS Biophysics. 2017;4(4):596-614. [DOI:10.3934/biophy.2017.4.596]
29. Zeng Q, Jin HZ, Qin JJ, Fu JJ, Hu XJ, Liu JH, et al. Chemical constituents of plants from the genus Dracocephalum. Chem Biodivers. 2010;7(8):1911-29. [DOI:10.1002/cbdv.200900188] [PMID]
30. Weremczuk-Jeżyna I, Grzegorczyk-Karolak I, Frydrych B, Królicka A, Wysokińska H. Hairy roots of Dracocephalum moldavica: rosmarinic acid content and antioxidant potential. Acta Physiol Plant. 2013;35(7):2095-103. [DOI:10.1007/s11738-013-1244-7]
31. Fattahi M, Nazeri V, Torras-Claveria L, Sefidkon F, Cusido RM, Zamani Z, et al. Identification and quantification of leaf surface flavonoids in wild-growing populations of Dracocephalum kotschyi by LC-DAD-ESI-MS. Food Chem. 2013;141(1):139-46. [DOI:10.1016/j.foodchem.2013.03.019] [PMID]
32. Babbar N, Oberoi HS, Uppal DS, Patil RT. Total phenolic content and antioxidant capacity of extracts obtained from six important fruit residues. Food Res Int. 2011;44(1):391-6. [DOI:10.1016/j.foodres.2010.10.001]
33. Kaufman SS, Vanderhoof JA, Young R, Perry D, Raynor SC, Mack DR. Gastroenteric inflammation in children with ulcerative colitis. Am J Gastroenterol. 1997;92(7).
34. Hendrickson BA. Gastric inflammation as a feature of ulcerative colitis. J Pediatr Gastroenterol Nutr. 2003;37(3):228-9. [DOI:10.1097/00005176-200309000-00005] [PMID]
| بازنشر اطلاعات | |
 |
این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است. |
