دوره 30، شماره 141 - ( 4-1401 )                   جلد 30 شماره 141 صفحات 318-314 | برگشت به فهرست نسخه ها


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Mohammadbeigi R, Hedayat B, Fathollahpour A, Hedayat S. Evaluation of Nifedipine Administration on Embryo Transfer Success Rate: a Randomized Clinical Trial. J Adv Med Biomed Res 2022; 30 (141) :314-318
URL: http://journal.zums.ac.ir/article-1-6312-fa.html
Evaluation of Nifedipine Administration on Embryo Transfer Success Rate: a Randomized Clinical Trial. Journal of Advances in Medical and Biomedical Research. 1401; 30 (141) :314-318

URL: http://journal.zums.ac.ir/article-1-6312-fa.html


چکیده:   (60283 مشاهده)

Background and Objective: In- vitro fertilization (IVF) is one of the approved treatment options for infertility. Despite many progresses in this field, its success rate is about 20 -25%. Utilization of drugs which suppress or decrease uterine smooth muscle contraction before embryo transfer, theoretically can improve fertility by increasing implantation rate. This study was designed to evaluate nifedipine administration on embryo transfer success.
Materials and Methods: In this double blinded randomized clinical trial, ninety-eight infertile women from primary and secondary causes were included in two groups; one group received placebo and the other group a  single dose of 20 mg nifedipine, both thirty minutes before embryo transfer. Primary outcome was defined as clinical pregnancy, and secondary outcomes as live birth, ectopic pregnancy, multiple gestation and abortion.
Results: Clinical pregnancy occurred in eighteen patients in the placebo group and in seventeen patients in nifedipine group (OR = 0.91, 0.40-2.09 (95% CI)). Sixteen patients in placebo group and fourteen patients in nifedipine group had successful live births (OR = 0.82, 0.34-1.95 (95% CI)). Multiple gestation (OR = 1.71, 0.24- 11.78 (95% CI)) and abortion (OR = 0.46, 0.07-2.95 (95% CI)) were not different between the two groups. No side effect of drug occurred in any group.
Conclusion: A single dose of 20 mg nifedipine tablet administered thirty minutes before IVF had no effect on improving clinical pregnancy and live birth rate. Using higher doses, or different regimens in specific patients’ subgroups may have more effect on embryo transfer success.

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نوع مطالعه: کارآزمایی بالینی | موضوع مقاله: Clinical medicine
دریافت: 1399/9/7 | پذیرش: 1401/3/25 | انتشار: 1401/4/9

فهرست منابع
1. Taylor HS, Pal L, Selli EU. Speroff's Clinical Gynecologic Endocrinology and Infertility (9th ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2020.
2. Steptoe PC, Edwards RG. Birth after the reimplantation of a human embryo. Lancet. 1978; 2:366. [DOI:10.1016/S0140-6736(78)92957-4]
3. Steptoe PC, Edwards RG. Reimplantation of a human embryo with subsequent tubal pregnancy. Lancet. 1976; 1:880. [DOI:10.1016/S0140-6736(76)92096-1]
4. Paulson RJ, Sauer MV, Lobo RA. Factors affecting embryo implantation after human invitro fertilization: A hypothesis. AM J Obstet Gynecol.1990; 163:2020. [DOI:10.1016/0002-9378(90)90790-E]
5. Kido A, Togashi K, Hatayama H, et al. Uterine peristalsis in women with repeated IVF failures: possible therapeutic effect of hyoscine bromide. J Obstet Gynaecol Can. 2009; 31: 732-5. [DOI:10.1016/S1701-2163(16)34278-5]
6. Fanchin R, Righini C, Olivennes F, Taylor S, de Ziegler D, Frydman R. Uterine contrac-tions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization. Hum Re-prod. 1998; 13: 1968-74. [DOI:10.1093/humrep/13.7.1968] [PMID]
7. Bulletti C, de Ziegler D. Uterine contractility and embryo implantation. Curr Opin Obstet Gynecol. 2006; 18: 473-84. [DOI:10.1097/01.gco.0000233947.97543.c4] [PMID]
8. Rabieie S, Farimani M, Ahmadi M. Evaluation of the effect of oral ritodrin on implanta-tion rate in IVF embryo transfer cylcles. Iran j Reprod Med. 2011;9(3);239-42.
9. Hanevik HI, Friberg M, Bergh A, Haraldsen C, Kahn JA. Do acetyl salicylic acid and ter-butaline in ombination increase the probability of a clinical pregnancy in patients undergoing IVF/ ICSI?. J Obstet Gynaecol.2012;32(8):786-9. [DOI:10.3109/01443615.2012.717988] [PMID]
10. Yuan C, Song H, Fan L, Su S, Dong B. The effect of atosiban on patients with difficult embryo transfer undergoing IVF embryo transfer. Reprod Sci.2019; 12:1613-17 [DOI:10.1177/1933719119831791] [PMID]
11. Huang QY, Rong MH, Lan AH, et al. The impact of atosiban on pregnancy outcomes in women undergoing IVF embryo transfer. PloS One.2017;12(4). [DOI:10.1371/journal.pone.0175501] [PMID] [PMCID]
12. Khairi Mohammad, Dhillon RK, Chu J, Rajkhowa M, Coomarasamy A. The effect peri-implantation administration of uterine relaxant agents in assisted reproduction treatment cylcle. Reprod Biomed .2016. 32;362-6. [DOI:10.1016/j.rbmo.2016.01.004] [PMID]
13. Nakai A, Togashi K, Kosaka K, et al. Do anticholinergic agents suppress uterine peristal-sis and sporadic myometrial contractions at cine MR imaging? Radiology 2008; 246: 489-96. [DOI:10.1148/radiol.2461062091] [PMID]
14. Conde-Agudelo A, Romero R, Kusanovic JP. Nifedipine in management of preterm la-bor: a systematic review ana metaanalsysis. Am J Obstet Gynecol. 2011; 204(2): 134.e1-20. [DOI:10.1016/j.ajog.2010.11.038] [PMID] [PMCID]
15. Amro FH, Moussa HN, Ashimi OA, Baha MS. Treatment options for hypertension in pregnancy and puerperium. Expert Opin Drug Saf .2016;15:1635-42. [DOI:10.1080/14740338.2016.1237500] [PMID]
16. Khan K, Zamora J, Lamont RF, Van Geijn H Hp, Svare J, Santos-Jorge C. Safety con-cerns for the use of calcium channel blockers in pregnancy for the treatment of spontaneous preterm labour and hypertension: a systematic review and meta-regression analysis. J Matern Fetal Neonatal Med .2010;23:1030-8. [DOI:10.3109/14767050903572182] [PMID]
17. Alavifard S, Chase R, Janoudi Gh, et al. First-line antihypertensive treatment for severe hypertension in pregnancy: A systematic review and network meta-analysis. Pregnancy Hy-pertension. 2019; 18:179-78. [DOI:10.1016/j.preghy.2019.09.019] [PMID]
18. Raheem I, Saaid R, Omar SZ, Tan PC. Oral nifedipine versus intravenous labetalol for acute blood pressure control in hypertensive emergencies of pregnany: a randomized trial. BJOG 2012; 119:78-85. [DOI:10.1111/j.1471-0528.2011.03151.x] [PMID]
19. Kwok LN K, Rozen G, Stewart T, Agresta F, Polyakov A. Does nifedipine improves outcomes of embryo transfer?. Medicine.2019; 98(4): e14251 [DOI:10.1097/MD.0000000000014251] [PMID] [PMCID]

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