دوره 30، شماره 142 - ( 7-1401 )                   جلد 30 شماره 142 صفحات 430-423 | برگشت به فهرست نسخه ها


XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Taghadosi M, Akbari H, Ganjoori F, Fakharian M. Effects of the Mouthwash Containing Pomegranate Seed Oil on Improving Oral Mucositis in Patients Undergoing Chemotherapy. J Adv Med Biomed Res 2022; 30 (142) :423-430
URL: http://journal.zums.ac.ir/article-1-6365-fa.html
Effects of the Mouthwash Containing Pomegranate Seed Oil on Improving Oral Mucositis in Patients Undergoing Chemotherapy. Journal of Advances in Medical and Biomedical Research. 1401; 30 (142) :423-430

URL: http://journal.zums.ac.ir/article-1-6365-fa.html


چکیده:   (47474 مشاهده)

Background and Objective: Oral mucositis (OM) is one of the most painful, and disabling oral inflammatory conditions caused by chemotherapy. This study aimed to determine the pomegranate seed oil (PSO) effect on improving chemotherapy-induced mucositis.
Materials and Methods: This single-blind, randomized, clinical trial recruited patients with chemotherapy-induced mucositis in the oncology ward of Shahid Beheshti Hospital in Kashan, Iran, in 2018 (n = 70). Patients were divided into two groups by randomized block design. The control group was treated with 15 ml of routine mouthwash 4 times daily for 14 days. The intervention group was treated with mixed solution of routine mouthwash and PSO (50:50). The mucositis severity was evaluated on the 1st, 7th and 14th days after the intervention using a checklist for assessing the mucositis severity. Data were analyzed using Chi-square, Fisher's exact, independent t and repeated measures ANOVA tests.
Results: The subjects’ mean ages in the intervention and control groups were 57.48±14.742 and 58.81±14.134 years, respectively. Groups were matched for clinical and demographic characteristics (P>0.05). The mean mucositis severity in the intervention group decreased from 1.97 on the 1st day to 0.52 on the 7th day and to 0.03 on the 14th day (P<0.001). The rates of mucositis severity in the control group were 1.98, 1.47 and 0.63, respectively on these days (P<0.001).
Conclusion: The mouthwash containing PSO improved chemotherapy-induced mucositis further than the routine mouthwash. Therefore, PSO can be used along with routine medicinal solutions to relieve and prevent oral mucositis symptoms.

متن کامل [PDF 474 kb]   (24372 دریافت)    
نوع مطالعه: کارآزمایی بالینی | موضوع مقاله: Clinical medicine
دریافت: 1399/10/21 | پذیرش: 1400/7/28 | انتشار: 1401/5/17

فهرست منابع
1. Kooshyar MM, Mozafari PM, Amirchaghmaghi M, et al. A randomized placebo-controlled double blind clinical trial of quercetin in the prevention and treatment of chemotherapy-induced oral mucositis. J Clin Diag Res. 2017;11(3):ZC46. [DOI:10.7860/JCDR/2017/23975.9571] [PMID] [PMCID]
2. Eslami H, Pouralibaba F, Falsafi P, et al. Efficacy of hypozalix spray and propolis mouthwash for prevention of chemotherapy-induced oral mucositis in leukemic patients: A double-blind randomized clinical trial. J Dent Res, Dent Clin, Dent Prospects. 2016;10(4):226-33. [DOI:10.15171/joddd.2016.036] [PMID] [PMCID]
3. Parkhill AL. Oral mucositis and stomatitis associated with conventional and targeted anticancer therapy. J Pharmacovigilance. 2013;1(4):1-4. [DOI:10.4172/2329-6887.1000112]
4. Miranzadeh S, Adib-Hajbaghery M, Soleymanpoor L, Ehsani M. A new mouthwash for chemotherapy induced stomatitis. Nurs Midwifery Stud. 2014;3(3): e20249. [DOI:10.17795/nmsjournal20249] [PMID] [PMCID]
5. Zand N, Ataie-Fashtami L, Djavid GE, et al. Relieving pain in minor aphthous stomatitis by a single session of non-thermal carbon dioxide laser irradiation. Laser Med Sci. 2009;24(4):515. [DOI:10.1007/s10103-008-0555-1] [PMID]
6. Albrektson M, Hedström L, Bergh H. Recurrent aphthous stomatitis and pain management with low-level laser therapy: a randomized controlled trial. Oral Surg, Oral Med, Oral Pathol ,Oral Radiol. 2014;117(5):590-4. [DOI:10.1016/j.oooo.2014.01.228] [PMID]
7. Bassampour SS, Bahramnezhad F, Mohammadi E, Larizadeh MH, Pedram Razi S, Haghani H. Effect of matrica mouth wash on prevention of head and neck radiotherapy induced-stomatitis. J Hayat. 2012;18(2):1-10.
8. Bahramnezhad F, Larizadeh MH, Mohammadi E, Haghani H, Yari M. Comparison of honey and chamomile mouthwash in intensity stomatitis among patients with head and neck radiotherapy. Complement Med J Nurs Midwif. 2013;3(2):429-40.
9. Mansour G, Ouda S, Shaker A, Abdallah HM. Clinical efficacy of new aloe vera‐and myrrh‐based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double‐blind, vehicle‐controlled study. J Oral Pathol Med. 2014;43(6):405-9. [DOI:10.1111/jop.12130] [PMID]
10. Kohno H, Suzuki R, Yasui Y, Hosokawa M, Miyashita K, Tanaka T. Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci. 2004;95(6):481-6. [DOI:10.1111/j.1349-7006.2004.tb03236.x] [PMID]
11. Lansky E, Shubert S, Neeman I. Pharmacological and therapeutic properties of pomegranate. Martínez-Nicolás JJ(ed), Martínez-Tomé J, ed Production, processing and marketing of pomegranate in the Mediterranean region: Advances in research and technology Zaragoza: CIHEAM. 2000:231-5.
12. Nuñez‐Sánchez MA, García‐Villalba R, Monedero‐Saiz T, et al. Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients. Molec Nutr Food Res. 2014;58(6):1199-211. [DOI:10.1002/mnfr.201300931] [PMID]
13. DiSilvestro RA, DiSilvestro DJ, DiSilvestro DJ. Pomegranate extract mouth rinsing effects on saliva measures relevant to gingivitis risk. Phytother Res. 2009;23(8):1123-7. [DOI:10.1002/ptr.2759] [PMID]
14. Batista ALA, Lins RDAU, de Souza Coelho R, do Nascimento Barbosa D, Belém NM, Celestino FJA. Clinical efficacy analysis of the mouth rinsing with pomegranate and chamomile plant extracts in the gingival bleeding reduction. Complement Therap Clin Pract. 2014;20(1):93-8. [DOI:10.1016/j.ctcp.2013.08.002] [PMID]
15. Lee CJ, Chen LG, Liang WL, Wang CC. Anti-inflammatory effects of Punica granatum Linne invitro and in vivo. Food Chem. 2010;118(2):315-22. [DOI:10.1016/j.foodchem.2009.04.123]
16. Panth N, Manandhar B, Paudel KR. Anticancer activity of Punica granatum (pomegranate): a review. Phytother Res. 2017;31(4):568-78. [DOI:10.1002/ptr.5784] [PMID]
17. Ibrahium M. Efficiency of pomegranate peel extract as antimicrobial, antioxidant and protective agents. World J Agri Sci. 2010;6(4):338-44.
18. Donnelly JP, Bellm LA, Epstein JB, Sonis ST, Symonds RP. Antimicrobial therapy to prevent or treat oral mucositis. The Lancet Infect Diseas. 2003;3(7):405-12. [DOI:10.1016/S1473-3099(03)00668-6]
19. Ghorbani M, Taghadosi M, Akbari H, Sharifi M. Effect of hydroalcoholic extract of Althaea officinalis root on improving chemotherapy-induced stomatitis: A randomized, double-blind, clinical trial. Nurs Midwif Stud. 2019;8(1):14-20. [DOI:10.4103/nms.nms_42_18]
20. Chiappelli F. The molecular immunology of mucositis: implications for evidence-based research in alternative and complementary palliative treatments. Evid Based Complement Alternat Med. 2005;2(4):489-94. [DOI:10.1093/ecam/neh129] [PMID] [PMCID]
21. César de Souza Vasconcelos L, Sampaio MCC, Sampaio FC, Higino JS. Use of punica granatum as an antifungal agent against candidosis associated with denture stomatitis. Mycoses. 2003;46(5‐6):192-6. [DOI:10.1046/j.1439-0507.2003.00884.x] [PMID]
22. Lalla RV, Sonis ST, Peterson DE. Management of oral mucositis in patients who have cancer. Dental Clin North America. 2008;52(1):61-77. [DOI:10.1016/j.cden.2007.10.002] [PMID] [PMCID]
23. Ashktorab T, Yazdani Z, Mojab F, Majd H, Madani H. Preventive effects of an oral rinse peppermint essence on chemotherapy-induced oral mucosistis. Koomesh. 2010;12(1).
24. Shabanloei R, Ahmadi F, Hajizadeh E, Javadzadeh Y. The effects of allopurinol mouthwash in the prevention of chemotherapy-induced stomatitis. Tehran Univ Med J. 2007;65(9):71-6.
25. Setiadhi R, Sufiawati I, Zakiawati D, Nur'aeny N, Hidayat W, Firman DR. Inhibition growth of pomegranate seeds extract against streptococcus sanguis: the cause of recurrent aphthous stomatitis. J Dentomaxillofac Sci. 2017;2(1):7-11. [DOI:10.15562/jdmfs.v2i1.452]
26. Khan JA, Hanee S. Antibacterial properties of Punica granatum peels. Int J Apply Biol Pharmaceut Technol. 2011;2(3):23-7.
27. Braga L, Shupp J, Cummings C, et al. Pomegranate extract inhibits Staphylococcus aureus growth and subsequent enterotoxin production. J Ethnopharmacol. 2005;96(1-2):335-9. [DOI:10.1016/j.jep.2004.08.034] [PMID]
28. Abdollahzadeh S, Mashouf R, Mortazavi H, Moghaddam M, Roozbahani N, Vahedi M. Antibacterial and antifungal activities of Punica granatum peel extracts against oral pathogens. J Dentist. 2011;8(1):1.
29. Vahabi S, Najafi E, Alizadeh S. In vitro antimicrobial effects of some herbal essences against oral pathogens. J Med Plant Res. 2011;5(19):4870-8.
30. Aguilar CN, Aguilera-Carbo A, Robledo A, et al. Production of antioxidant nutraceuticals by solid-state cultures of pomegranate (Punica granatum) peel and creosote bush (Larrea tridentata) leaves. Food Technol Biotechnol. 2008;46(2):218.
31. Burapadaja S, Bunchoo A. Antimicrobial activity of tannins from Terminalia citrina. Planta Medica. 1995;61(04):365-6. [DOI:10.1055/s-2006-958103] [PMID]
32. Endo EH, Cortez DAG, Ueda-Nakamura T, Nakamura CV, Dias Filho BP. Potent antifungal activity of extracts and pure compound isolated from pomegranate peels and synergism with fluconazole against Candida albicans. Res Microbiol. 2010;161(7):534-40. [DOI:10.1016/j.resmic.2010.05.002] [PMID]
33. Vasconcelos LCdS, Sampaio FC, Sampaio MCC, Pereira MdSV, Higino JS, Peixoto MHP. Minimum inhibitory concentration of adherence of Punica granatum Linn (pomegranate) gel against S. mutans, S. mitis and C. albicans. Brazil Dental J. 2006;17(3):223-7. [DOI:10.1590/S0103-64402006000300009] [PMID]
34. Haghighian MK, Rafraf M, Moghaddam A, Hemmati S, Jafarabadi MA, Gargari BP. Pomegranate (Punica granatum L.) peel hydro alcoholic extract ameliorates cardiovascular risk factors in obese women with dyslipidemia: A double blind, randomized, placebo controlled pilot study. Europ J Integrat Med. 2016;8(5):676-82. [DOI:10.1016/j.eujim.2016.06.010]
35. Howell AB, D'Souza DH. The pomegranate: effects on bacteria and viruses that influence human health. Evid Based Complement Alternat Med. 2013;2013: 606212 [DOI:10.1155/2013/606212] [PMID] [PMCID]

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Journal of Advances in Medical and Biomedical Research می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | Journal of Advances in Medical and Biomedical Research

Designed & Developed by : Yektaweb