دوره 30، شماره 139 - ( 11-1400 )                   جلد 30 شماره 139 صفحات 122-116 | برگشت به فهرست نسخه ها


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Mazloomi S, Barartabar Z, Danesh H, Alizadeh N, Pilehvari S. Association of Low Zinc Concentration and Hyperleptinemia with Overweight and Insulin Resistance in Polycystic Ovary Syndrome Women. J Adv Med Biomed Res 2022; 30 (139) :116-122
URL: http://journal.zums.ac.ir/article-1-6395-fa.html
Association of Low Zinc Concentration and Hyperleptinemia with Overweight and Insulin Resistance in Polycystic Ovary Syndrome Women. Journal of Advances in Medical and Biomedical Research. 1400; 30 (139) :116-122

URL: http://journal.zums.ac.ir/article-1-6395-fa.html


چکیده:   (94364 مشاهده)

Background and Objective: It has been reported that low concentration of zinc in serum is associated with insulin resistance (IR), also appears to be a relationship between insulin and leptin. In this study the possibility of increased leptin concentration and zinc deficiency was evaluated; in the following, their relationship with overweight and IR was investigated in women with polycystic ovary syndrome (PCOS).
Materials and Methods: In this case-control study, 104 PCOS involved cases and 99 healthy individuals as control were included. Blood specimens were collected from participants post overnight fasting period; zinc concentrations (spectrophotometry method), leptin (ELISA method), insulin (ECLIA method), lipid profiles and glucose were measured with enzymatic method. The homeostasis model assessment (HOMA) index determined the IR level.
Results: Zinc level was 87.20 ± 11.32 μg/dl in PCOS group, and 113.68 ± 8.31μg/dl in control group. Leptin  concentration was 23.06 ± 3.33 ng/mL and 19.37 ± 3.34 ng/mL, and IR was 2.37 ± 0.83 and 1.45 ± 0.74 in case and control groups, respectively (all p<0.001). Zinc had marked negative correlation with leptin, insulin, and IR (p<0.001). According to the subject, which waist circumference and body mass index (BMI) parameters were confounding factors, hyperleptinemia and zinc decrement significantly affected PCOS subjects. In contrast, only zinc decrement had an association with PCOS, after eliminating the confounding factors (OR: 0.782, p<0.001).
Conclusion: Zinc reduction is more effective on PCOS than hyperleptinemia. Hyperleptinemia has association with waist circumference and BMI; it can also affect PCOS.

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نوع مطالعه: مقاله پژوهشی | موضوع مقاله: Clinical medicine
دریافت: 1399/11/6 | پذیرش: 1400/4/3 | انتشار: 1400/11/11

فهرست منابع
1. Cernea S, Both E, Huţanu A, Şular FL, Roiban AL. Correlations of serum leptin and leptin resistance with depression and anxiety in patients with type 2 diabetes. Psychiatr Clin Neurosci. 2019;73(12):745-53. [DOI:10.1111/pcn.12922] [PMID]
2. Ramos-Lobo AM, Donato Jr J. The role of leptin in health and disease. Temperature. 2017;4(3):258-91. [DOI:10.1080/23328940.2017.1327003] [PMID] [PMCID]
3. Cernea S, Roiban AL, Both E, Huţanu A. Serum leptin and leptin resistance correlations with NAFLD in patients with type 2 diabetes. Diabet Res Rev. 2018;34(8):e3050. [DOI:10.1002/dmrr.3050] [PMID]
4. Marroquí L, Gonzalez A, Ñeco P, et al. Role of leptin in the pancreatic β-cell: effects and signaling pathways. J Molec Endocrinol. 2012;49(1):R9-R17. [DOI:10.1530/JME-12-0025] [PMID]
5. Kieffer T, Habener JF. The glucagon-like peptides Endocr Rev. 1999;20:876-913. [DOI:10.1210/edrv.20.6.0385] [PMID]
6. Rios-Lugo MJ, Madrigal-Arellano C, Gaytán-Hernández D, Hernández-Mendoza H, Romero-Guzmán ET. Association of serum zinc levels in overweight and obesity. Biol Trace Element Res. 2020;198(1):51-7. [DOI:10.1007/s12011-020-02060-8] [PMID]
7. Severo JS, Morais J, Beserra JB, et al. Biomarkers of cardiovascular risk in obese women and their relationship with zinc status. Curr Nutr Food Sci. 2020;16(5):734-42. [DOI:10.2174/1573401315666191125113128]
8. Thoen RU, Barther NN, Schemitt E, et al. Zinc supplementation reduces diet-induced obesity and improves insulin sensitivity in rats. Apply Physiol Nutr Metab. 2019;44(6):580-6. [DOI:10.1139/apnm-2018-0519] [PMID]
9. Forslund M, Landin-Wilhelmsen K, Trimpou P, Schmidt J, Brännström M, Dahlgren E. Type 2 diabetes mellitus in women with polycystic ovary syndrome during a 24-year period: importance of obesity and abdominal fat distribution. Human Reproduct Open. 2020;2020(1):hoz042. [DOI:10.1093/hropen/hoz042] [PMID] [PMCID]
10. Bannigida DM, Nayak BS, Vijayaraghavan R. Insulin resistance and oxidative marker in women with PCOS. Arch Physiol Biochem. 2020;126(2):183-6. [DOI:10.1080/13813455.2018.1499120] [PMID]
11. Legro RS, Castracane VD, Kauffman RP. Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls. Obstet Gynecol Survey. 2004;59(2):141-54. [DOI:10.1097/01.OGX.0000109523.25076.E2] [PMID]
12. Sharifi F, Hajihosseini R, Mazloomi S, Amirmogaddami H, Nazem H. Decreased adiponectin levels in polycystic ovary syndrome, independent of body mass index. Metab Syndrome Relat Disorder. 2010;8(1):47-52. [DOI:10.1089/met.2009.0036] [PMID]
13. Barber TM, Franks S. Obesity and polycystic ovary syndrome. Clin Endocrinol. 2021;95(4):531-41. [DOI:10.1111/cen.14421] [PMID]
14. Murri M, Luque-Ramírez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF. Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis. Human Reproduct Update. 2013;19(3):268-88. [DOI:10.1093/humupd/dms059] [PMID]
15. Carmina E. Diagnosis of polycystic ovary syndrome: from NIH criteria to ESHRE-ASRM guidelines. Minerva Ginecologica. 2004;56(1):1-6.
16. Bermúdez V, Cano R, Cano C, et al., editors. Homeostasis model assessment (HOMA) as surrogate insulinization criteria in patients with type 2 diabetes. Am J Therapeutics; 2008: LWW. [DOI:10.1097/MJT.0b013e318160b909] [PMID]
17. Abedini M, Ghaedi E, Hadi A, Mohammadi H, Amani R. Zinc status and polycystic ovarian syndrome: A systematic review and meta-analysis. J Trace Element Med Biol. 2019;52:216-21. [DOI:10.1016/j.jtemb.2019.01.002] [PMID]
18. Kanafchian M, Mahjoub S, Esmaeilzadeh S, Rahsepar M, Mosapour A. Status of serum selenium and zinc in patients with the polycystic ovary syndrome with and without insulin resistance. Middle East Fertil Soc J. 2018;23(3):241-5. [DOI:10.1016/j.mefs.2017.11.003]
19. Kulhan M, Kulhan NG, Nayki UA, et al. Assessment of the relationship between serum vitamin (A, B 12, C, D, folate) and zinc levels and polycystic ovary syndrome. Arch Med Sci-Civil Disease. 2017;2(1):62-9. [DOI:10.5114/amscd.2017.66840]
20. Aliyev U, Pehlivantürk-Kızılkan M, Düzçeker Y, et al. Is there any association between hirsutism and serum zinc levels in adolescents? Biol Trace Element Res. 2020;198(2):403-9. [DOI:10.1007/s12011-020-02086-y] [PMID]
21. Taher MA, Mhaibes SH. Assessment of some trace elements in obese and non-obese polycystic ovary syndrome (PCOS). Int J Sci Res. 2017;6(9):1333-41.
22. Jalilian N, Haghnazari L, Rasolinia S. Leptin and body mass index in polycystic ovary syndrome. Indian J Endocrinol Metab. 2016;20(3):324. [DOI:10.4103/2230-8210.180005] [PMID] [PMCID]
23. Baldani DP, Skrgatic L, Kasum M, Zlopasa G, Kralik Oguic S, Herman M. Altered leptin, adiponectin, resistin and ghrelin secretion may represent an intrinsic polycystic ovary syndrome abnormality. Gynecol Endocrinol. 2019;35(5):401-5. [DOI:10.1080/09513590.2018.1534096] [PMID]
24. Laughlin G, Morales A, Yen S. Serum leptin levels in women with polycystic ovary syndrome: the role of insulin resistance/hyperinsulinemia. J Clin Endocrinol Metab. 1997;82(6):1692-6. https://doi.org/10.1210/jcem.82.6.4028 [DOI:10.1210/jc.82.6.1692] [PMID]
25. Beyazit F, Hiz MM, Turkon H, Unsal MA. Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism. Ginekologia Polska. 2021. [DOI:10.5603/GP.a2020.0176] [PMID]
26. Daghestani MH, Daghestani M, Daghistani M, et al. A study of ghrelin and leptin levels and their relationship to metabolic profiles in obese and lean Saudi women with polycystic ovary syndrome (PCOS). Lipid Health Disease. 2018;17(1):1-9. [DOI:10.1186/s12944-018-0839-9] [PMID] [PMCID]
27. Sharif E, Rizk NM. Leptin and free leptin receptor is associated with polycystic ovary syndrome in young women. 2015. [DOI:10.1155/2015/927805] [PMID] [PMCID]
28. Anwar AA, Abdullah N, Padjalangi AN, Hamid F, Mappeware NA, Lukas E. Serum leptin concentration is correlated to insulin resistance in polycystic ovary syndrome (PCOS) patients. Molec Cell Biomed Sci. 2021;5(2):93-7. [DOI:10.21705/mcbs.v5i2.203]
29. Houjeghani S, Gargari BP, Farzadi L. Serum leptin and ghrelin levels in women with polycystic ovary syndrome: correlation with anthropometric, metabolic, and endocrine parameters. Int J Fertil Steril. 2012;6(2):117.
30. Shirazi FKH, Khodamoradi Z, Jeddi M. Insulin resistance and high molecular weight adiponectin in obese and non-obese patients with Polycystic Ovarian Syndrome (PCOS). BMC Endocrine Disorder. 2021;21(1):1-7. [DOI:10.1186/s12902-021-00710-z] [PMID] [PMCID]

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