دوره 30، شماره 140 - ( 2-1401 )                   جلد 30 شماره 140 صفحات 222-215 | برگشت به فهرست نسخه ها

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Cheraghi pour M, Khaleghi F, Namiranian N, Ansari K, Mansouri M, Injinari N et al . Relationship between Severity of Primary Lung Involvement with Erythrocyte Sedimentation Rate and Lactate Dehydrogenase in Patients with COVID-19 in Yazd. J Adv Med Biomed Res 2022; 30 (140) :215-222
URL: http://journal.zums.ac.ir/article-1-6451-fa.html
Relationship between Severity of Primary Lung Involvement with Erythrocyte Sedimentation Rate and Lactate Dehydrogenase in Patients with COVID-19 in Yazd. Journal of Advances in Medical and Biomedical Research. 1401; 30 (140) :215-222

URL: http://journal.zums.ac.ir/article-1-6451-fa.html

Relationship between Severity of Primary Lung Involvement with Erythrocyte Sedimentation Rate and Lactate Dehydrogenase in Patients with COVID-19 in Yazd
چکیده:   (84486 مشاهده)

Background and Objective: Measurement of inflammatory markers and lactate dehydrogenase (LDH) may contribute to the evaluation of lung involvement severity. This study aimed to evaluate relationship between severity of primary lung involvement with highest level of erythrocyte sedimentation rate (ESR) and LDH in patients with COVID-19.
Materials and Methods: This descriptive-analytical study was conducted on 123 patients with COVID-19 in Shahid Sadoughi Hospital. Data including age, gender, ESR (mm/h), LDH (U/L), and high-resolution Computed Tomography scan (HRCT) findings and hospitalization ward were extracted from medical records. The regression model was used to determine the relation between HRCT findings with LDH and ESR.
Results: Mean LDH, ESR, and HRCT findings were 508.41±224.65, 52.23±29.56, and 37.17± 22.18 respectively. A significant relation was seen between HRCT findings with highest level of LDH and ESR (P=0.001). A significant relation was observed between the highest levels of ESR and HRCT findings, regarding age, gender, and hospitalization wards (P<0.01). There was a significant relation between the highest level of LDH and HRCT findings regarding age group and hospitalization wards (P<0.01).
Conclusion: A significant relation was seen between HRCT findings and highest levels of ESR and LDH in patients with COVID-19. Therefore, it seems that assessment of laboratory findings such as LDH and ESR can be helpful as cost-effective markers instead of chest CT scan for predicting the severity of lung injury when the CT scan report is controversial. The relation between HRCT findings with LDH and ESR were affected by age and hospitalization ward. However, more studies should be conducted in this regard.

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نوع مطالعه: مقاله پژوهشی | موضوع مقاله: Clinical medicine
دریافت: 1399/12/10 | پذیرش: 1400/6/8 | انتشار: 1401/1/12
فهرست منابع
1. Zareie B, Roshani A, Mansournia MA, Rasouli MA, Moradi G. A model for COVID-19 prediction in Iran based on China parameters. MedRxiv. 2020. [DOI:10.1101/2020.03.19.20038950]
2. Kong M. Higher level of neutrophil-to-lymphocyte is associated with severe COVID-19. Epidemiol Infect. 148, e139, 1-6. [DOI:10.1017/S0950268820001557] [PMID] [PMCID]
3. Xie X, Zhong Z. Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing. Radiology. 2020; 200343
4. Corman VM, Landt O, Kaiser M, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. 2020; Euro Surveill, v.25(3); 2020 PMC6988269 [DOI:10.2807/1560-7917.ES.2020.25.3.2000045]
5. Gao L. Pulmonary high-resolution computed tomography (HRCT) findings of patients with early-stage coronavirus disease 2019 (COVID-19) in Hangzhou, China. Med Sci Monit, 2020; 26: e923885 [DOI:10.12659/MSM.923885]
6. Kashyape R, Jain R. The utility of HRCT in the initial diagnosis of COVID-19 pneumonia-An Indian perspective. Indian J Radiol Imaging (Suppl 1):S178. Available from: /pmc/articles/PMC7996707/ [DOI:10.4103/ijri.IJRI_944_20] [PMID] [PMCID]
7. Tuttolomondo D, Gaibazzi N, Sartorio D, Borrello B, Nicolini F .Coronary involvement findings on chest HRCT in COVID-19 patients. Insight Biomed. 2020;1-9
8. Henry M, Aggarwal G , Wong Jc ,et al. Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis. Am J Emerg Med 2020;38: 1722-26 [DOI:10.1016/j.ajem.2020.05.073] [PMID] [PMCID]
9. Wu M. Clinical evaluation of potential usefulness of serum lactate dehydrogenase (LDH) in 2019 novel coronavirus (COVID-19) pneumonia. Respiratory Research (2020) 21:171 [DOI:10.1186/s12931-020-01427-8] [PMID] [PMCID]
10. Kolev Y, Uetake H, Takagi Y, Sugihara K. Lactate dehydrogenase-5 (LDH-5) expression in human gastric cancer: association with hypoxia-inducible factor (HIF-1alpha) pathway, angiogenic factors production and poor prognosis. Ann Surg Oncol. 2008;15(8):2336-44. [DOI:10.1245/s10434-008-9955-5] [PMID]
11. Uchide N, Ohyama K, Bessho T, Toyoda H. Lactate dehydrogenase leakage as a marker for apoptotic cell degradation induced by influenza virus infection in human fetal membrane cells. Intervirology. 2009;52(3):164-73. [DOI:10.1159/000224644] [PMID]
12. Amerio P, Girardelli CR, Proietto G, Forleo P, Cerritelli L, Feliciani C, Colonna L, Teofoli P, Amerio P, Puddu P, et al. Usefulness of erythrocyte sedimentation rate as tumor marker in cancer associated dermatomyositis. Eur J Dermatol 2002; 12: 165-9.
13. Zeng F, Huang Y, Association of inflammatory markers with the severity of COVID-19: A meta-analysis. International Journal of Infectious Diseases 2020; 467-474. [DOI:10.1016/j.ijid.2020.05.055] [PMID] [PMCID]
14. Sobhani S, Aryan R, Kalantari E, Soltani S, Malek N, Pirzadeh P, et al. Association between Clinical Characteristics and Laboratory Findings with Outcome of Hospitalized COVID-19 Patients: A Report from Northeast Iran. Interdiscip Perspect Infect Dis. 2021;2021. [DOI:10.1101/2021.01.23.21250359]
15. Ghahramani S, Tabrizi R, Lankarani KB, Kashani SMA, Rezaei S, Zeidi N, et al. Laboratory features of severe vs. non-severe COVID-19 patients in Asian populations: a systematic review and meta-analysis. Eur J Med Res 2020 251 [Internet]. 2020 Aug 3 [cited 2021 Aug 17];25(1):1-10. Available from: https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-020-00432-3 [DOI:10.1186/s40001-020-00432-3] [PMID] [PMCID]
16. Soleimani N, Faridnouri H, Dayer M. The Effect of Dusts on Liver Enzymes and Kidney Parameters of Serum in Male Rats in Khuzestan, Iran. Journal of Chemical Health Risks. 2020 Dec 1;10(4):315-26.
17. Shimi G, Sohrab G, Pourvali K, Ghorbani A, Balam FH, Rostami K, Zand H. Correlation of Low Levels of α-1 Antitrypsin and Elevation of Neutrophil to Lymphocyte Ratio with Higher Mortality in Severe COVID-19 Patients. Mediators of Inflammation. 2021 Apr 28;2021. [DOI:10.1155/2021/5555619] [PMID] [PMCID]
18. Erez A, Shental O, Tchebiner JZ, et al. Diagnostic and prognostic value of very high serum lactate dehydrogenase in admitted medical patients. Isr Med Assoc J. 2014; 16(7):439-43.
19. Chen CY, Lee CH, Liu CY, Wang JH, Wang LM, Perng RP. Clinical features and outcomes of severe acute respiratory syndrome and predictive factors for acute respiratory distress syndrome. J Chin Med Assoc. 2005;68(1):4-10. [DOI:10.1016/S1726-4901(09)70124-8]
20. Wimazal F, Sperr WR, Kundi M, Vales A, Fonatsch C, Thalhammer-Scherrer R, et al. Prognostic significance of serial determinations of lactate dehydrogenase (LDH) in the follow-up of patients with myelodysplastic syndromes. Ann Oncol. 2008;19(5):970-6. [DOI:10.1093/annonc/mdm595] [PMID]
21. Scartozzi M, Giampieri R, Maccaroni E, Del Prete M, Faloppi L, Bianconi M, et al. Pre-treatment lactate dehydrogenase levels as predictor of efficacy of first-line bevacizumab-based therapy in metastatic
22. Aggrawel A. Clinical features, laboratory characteristics, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19): Early report from the United States
23. Parvizpour F, Abdulahi A, Salehi MR, Mahmoudi M, Saeedifar R. Comparison of Laboratory Parameters in Patients with COVID-19. SSRN Electron J [Internet]. 2021 Jun 12 [cited 2021 Aug 18]; Available from: https://papers.ssrn.com/abstract=3860394 [DOI:10.2139/ssrn.3860394]
24. Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis. 2013;13(9):752-61. [DOI:10.1016/S1473-3099(13)70204-4]
25. Luo. Association between chest CT features and clinical course of Coronavirus Disease 2019. Respir Med. 2020 ; 168: 105989 [DOI:10.1016/j.rmed.2020.105989] [PMID] [PMCID]
26. Zeng F. Association of inflammatory markers with the severity of COVID-19: A meta-analysis. International Journal of Infectious Diseases 2020; 96: 467-474 [DOI:10.1016/j.ijid.2020.05.055] [PMID] [PMCID]
27. Go D. Elevated Erythrocyte Sedimentation Rate Is Predictive of Interstitial Lung Disease and Mortality in Dermatomyositis: a Korean Retrospective Cohort Study. J Korean Med Sci. 2016;31(3):389-96.
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