دوره 31، شماره 145 - ( 12-1401 )                   جلد 31 شماره 145 صفحات 151-144 | برگشت به فهرست نسخه ها


XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rashidi Maybodi F, Bashiri H, Sezavar K, Owlia F. Oral Manifestations and Its Associated Factors in Iranian Systemic Lupus Erythematosus (SLE) Patients. J Adv Med Biomed Res 2023; 31 (145) :144-151
URL: http://journal.zums.ac.ir/article-1-6884-fa.html
Oral Manifestations and Its Associated Factors in Iranian Systemic Lupus Erythematosus (SLE) Patients. Journal of Advances in Medical and Biomedical Research. 1401; 31 (145) :144-151

URL: http://journal.zums.ac.ir/article-1-6884-fa.html


چکیده:   (11044 مشاهده)

Background and Objective: Due to the overall wide range of oral manifestations and the lack of comprehensively categorized information in Iran, this study was performed to investigate the prevalence of different oral manifestations and report their possible associated factors in patients with SLE.
Materials and Methods: This cross-sectional study was performed on 96 SLE patients referred to two rheumatology clinics in Yazd, Iran, from September 2020 to February 2021. SLE patients were diagnosed based on the last revision of American College of Rheumatology (ACR) criteria in 1997. A questionnaire was created to collect demographic information and oral health status. Data were analyzed using SPSS v20.0 and p-values of P < 0.05 were considered statistically significant.
Results: This study included 13 men (13.5%) and 83 women (86.5%), with an average age of 31.9 ±11.35 years. Oral lesions were diagnosed in 64.4% of patients, with white and red lesions being the most frequent (58%), and the most common region involved was buccal mucosa (25.8%). 97.1% of participants had caries and 86.5% had periodontal diseases. There was a significant association between the presence of oral lesions and female gender, longer duration and higher activity level of the disease and simultaneous presence of periodontal disease and missing or filled teeth. (P < 0.05).
Conclusion: Given the frequency of oral lesions in more than 60% of patients, as well as the high incidence of caries and periodontal disorders, regular oral examinations in these patients appear to be particularly important.

متن کامل [PDF 364 kb]   (7845 دریافت)    
نوع مطالعه: مقاله پژوهشی | موضوع مقاله: Epidemiologic studies
دریافت: 1400/11/24 | پذیرش: 1401/7/28 | انتشار: 1401/12/22

فهرست منابع
1. Signorini V, Elefante E, Zucchi D, et al. One year in review 2020: systemic lupus erythematosus. Clin Exp Rheumatol. 2020;38(4):592-601.
2. Denny DE, Rai S, Jacob SE, Thomas MS. Hypersensitivity reactions and dental considerations-an overview. J Int Dent Med Res. 2021;14(1):360-6.
3. Greenberg M, Glick M. Burket's oral medicine diagnosis and treatment. 11 the ed. Ontario: BC Decker Inc.; 2008.
4. Regezi JA, Sciubba JJ, Jordan RC. Oral pathology: clinical pathologic correlations. 7th ed. St Louis: Elsevier Health Sciences; 2017.
5. Benli M, Batool F, Stutz C, et al. Orofacial manifestations and dental management of systemic lupus erythematosus: A review. Oral Dis. 2021;27(2):151-67. [DOI:10.1111/odi.13271] [PMID]
6. Del Barrio-Díaz P, Reyes-Vivanco C, Cifuentes-Mutinelli M, Manríquez J, Vera-Kellet C. Association between oral lesions and disease activity in lupus erythematosus. J Eur Acad Dermatol Venereol. 2020;34(2):349-56. [DOI:10.1111/jdv.15980] [PMID]
7. Al-Mutairi KD, Al-Zahrani MS, Bahlas SM, Kayal RA, Zawawi KH. Periodontal findings in systemic lupus erythematosus patients and healthy controls. Saudi Med J. 2015;36(4):463. [DOI:10.15537/smj.2015.4.10746] [PMID] [PMCID]
8. Fabbri C, Fuller R, Bonfá E, et al. Periodontitis treatment improves systemic lupus erythematosus response to immunosuppressive therapy. Clin Rheumatol. 2014;33(4):505-9. [DOI:10.1007/s10067-013-2473-2] [PMID]
9. Marques C, Maor Y, De Andrade M, Rodrigues V, Benatti B. Possible evidence of systemic lupus erythematosus and periodontal disease association mediated by Toll‐like receptors 2 and 4. Clin Exp Immunol. 2016;183(2):187-92. [DOI:10.1111/cei.12708] [PMID] [PMCID]
10. Hammoudeh M, Al-Momani A, Sarakbi H, Chandra P, Hammoudeh S. Oral Manifestations of systemic lupus erythematosus patients in Qatar: A pilot study. Int J Rheumatol. 2018;2018:6052326. [DOI:10.1155/2018/6052326] [PMID] [PMCID]
11. Handayani R, Subita GP, Pradono SA. Oral mucosal lesions as initial presentation in lupus erythematosus patient (A Case Report). Atlantis Press J. 2018;IDCSU 2017:247-50. [DOI:10.2991/idcsu-17.2018.63]
12. Maybodi FR, Bashiri H, Sezavar K, Owlia F. Effect of periodontal treatment on serum inflammatory parameters and disease activity in patients with systemic lupus erythematosus: A randomized controlled trial. J Indian Soc Periodontol. 2022;26(6):564-9. [DOI:10.4103/jisp.jisp_607_21] [PMID] [PMCID]
13. Cardoso IL, Leal F, Regis RC. Systemic lupus erythematosus and implications for the oral cavity. J Med Care Res Rev. 2020;3(9):444-53. [DOI:10.15520/mcrr.v3i9.142]
14. Hochberg MC. Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40(9):1725. [DOI:10.1002/art.1780400928] [PMID]
15. Petri M, Orbai AM, Alarcón GS, et al. Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012;64(8):2677-86. [DOI:10.1002/art.34473] [PMID] [PMCID]
16. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH. Derivation of the SLEDAI. A disease activity index for lupus patients. The committee on prognosis studies in SLE. Arthritis and rheumatism. 1992;35(6):630-40. [DOI:10.1002/art.1780350606] [PMID]
17. Caton JG, Armitage G, Berglundh T, et al. A new classification scheme for periodontal and peri‐implant diseases and conditions-Introduction and key changes from the 1999 classification. J Clin Periodontol. 2018;45(45 Suppl 20):S1-S8. [DOI:10.1111/jcpe.12935] [PMID]
18. Chacón-Dulcey V, López-Labady J, Villarroel-Dorrego M, et al. Oral manifestations associated with antimalarial therapy in patients with systemic lupus erythematosus. Lupus. 2020;29(7):761-6. [DOI:10.1177/0961203320922620] [PMID]
19. Menzies S, O'Shea F, Galvin S, Wynne B. Oral manifestations of lupus. Ir J Med Sci. 2018;187(1):91-3. [DOI:10.1007/s11845-017-1622-z] [PMID]
20. Nazarinia MA, Ghaffarpasand F, Shamsdin A, et al. Systemic lupus erythematosus in the Fars province of Iran. Lupus. 2008;17(3):221-7. [DOI:10.1177/0961203307086509] [PMID]
21. Wang J, Yang S, Chen J, et al. Systemic lupus erythematosus: a genetic epidemiology study of 695 patients from China. Arch Dermatol Res. 2007;298(10):485-91. [DOI:10.1007/s00403-006-0719-4] [PMID]
22. Aurlene N, Manipal S, Prabu D, Rajmohan. Prevalence of oral mucosal lesions, dental caries, and periodontal disease among patients with systemic lupus erythematosus in a teaching hospital in Chennai, Tamil Nadu. J Family Med Prim Care. 2020;9(7):3374-80. [DOI:10.4103/jfmpc.jfmpc_1263_19] [PMID] [PMCID]
23. Zakeri Z, Narouie B, Bakhshipour A, Sarabadani J. Prevalence of oral manifestations in patient with systemic lupus erythematosus (SLE). Life Sci J. 2012;9(3):1307-11.
24. Rezvaninejad R, Dadmehr M, Rezvaninejad R. Prevalence of oral manifestations in systemic lupus erythematosus patients referred to Shahid Mohammadi Hospital in 2018-2019. Jundishapur J Health Sci. 2021;13(2). e116144 [DOI:10.5812/jjhs.116144]
25. Villamin CA, Navarra SV. Clinical manifestations and clinical syndromes of Filipino patients with systemic lupus erythematosus. Mod Rheumatol. 2008;18(2):161-4. [DOI:10.3109/s10165-008-0029-0]
26. Brennan MT, Valerin MA, Napeñas JJ, Lockhart PB. Oral manifestations of patients with lupus erythematosus. Dent Clin North Am. 2005;49(1):127-41, ix. [DOI:10.1016/j.cden.2004.07.006] [PMID]
27. De Rossi SS, Glick M. Lupus erythematosus: considerations for dentistry. J Am Dent Assoc. 1998;129(3):330-9. [DOI:10.14219/jada.archive.1998.0207] [PMID]
28. Lourenço SV, de Carvalho FR, Boggio P, et al. Lupus erythematosus: clinical and histopathological study of oral manifestations and immunohistochemical profile of the inflammatory infiltrate. J Cutan Pathol. 2007;34(7):558-64. [DOI:10.1111/j.1600-0560.2006.00652.x] [PMID]
29. Khatibi M, Shakoorpour AH, Jahromi ZM, Ahmadzadeh A. The prevalence of oral mucosal lesions and related factors in 188 patients with systemic lupus erythematosus. Lupus. 2012;21(12):1312-5. [DOI:10.1177/0961203312454589] [PMID]
30. Chakravarty E, Michaud K, Katz R, Wolfe F. Increased incidence of Herpes Zoster among patients with systemic lupus erythematosus. Lupus. 2013;22(3):238-44. [DOI:10.1177/0961203312470186] [PMID]
31. Leite DA GM, Silva OG, Fernandes V, Lima PRTL, Briezinski JP, Dias EP. Prevalence of oral candidiasis in patients with systemic lupus erythematosus. Oral Surg Oral Med Oral Pathol. 2012;114(4):e50. [DOI:10.1016/j.oooo.2012.08.039]
32. de Pablo P, Dewan K, Dietrich T, Chapple I, Gordon C. Periodontal disease is common in patients with systemic lupus erythemathosus. Ann Rheum Dis. 2015;74:1101. [DOI:10.1136/annrheumdis-2015-eular.6245]
33. Gofur NRP, Handono K, Nurdiana N, Kalim H, Barlianto W. Oral hygiene and dental caries status on systemic lupus erythematosus patients: A cross-sectional study. Pesqui Bras Odontopediatria Clín Integr. 2020;20:0013. [DOI:10.1590/pboci.2020.116]
34. Loyola Rodriguez JP, Galvan Torres LJ, Martinez Martinez RE, et al. Frequency of dental caries in active and inactive systemic lupus erythematous patients: salivary and bacterial factors. Lupus. 2016;25(12):1349-56. [DOI:10.1177/0961203316640909] [PMID]
35. Kudsi, M., Nahas, L.D., Alsawah, R. et al. The prevalence of oral mucosal lesions and related factors in systemic lupus erythematosus patients. Arthritis Res Ther 2021; 23: 229. [DOI:10.1186/s13075-021-02614-8] [PMID] [PMCID]
36. Kole AK, Ghosh A. Cutaneous manifestations of systemic lupus erythematosus in a tertiary referral center. Indian J Dermatol. 2009;54(2):132-6. [DOI:10.4103/0019-5154.53189] [PMID] [PMCID]
37. Saccucci M, Di Carlo G, Bossù M, et al. Autoimmune diseases and their manifestations on oral cavity: diagnosis and clinical management. J Immunol Res. 2018;2018:6061825. [DOI:10.1155/2018/6061825] [PMID] [PMCID]

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Journal of Advances in Medical and Biomedical Research می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | Journal of Advances in Medical and Biomedical Research

Designed & Developed by : Yektaweb