یکشنبه 2 دی 1403
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دوره 31، شماره 148 - ( 8-1402 )
جلد 31 شماره 148 صفحات 440-432 |
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Rezaieyazdi Z, Sarraf A, khodashahi M, Sahebari M, Jarahi L, Rahimi H R et al . Effect of Oral Curcumin on Rheumatoid Arthritis Patients: A Double-Blind Randomized Clinical Trial. J Adv Med Biomed Res 2023; 31 (148) :432-440
URL: http://journal.zums.ac.ir/article-1-6931-fa.html
URL: http://journal.zums.ac.ir/article-1-6931-fa.html
Effect of Oral Curcumin on Rheumatoid Arthritis Patients: A Double-Blind Randomized Clinical Trial. Journal of Advances in Medical and Biomedical Research. 1402; 31 (148) :432-440
چکیده: (1546 مشاهده)
Background and Objective: Incomprehensive studies have examined the therapeutic and side effects of curcumin on the treatment of debilitating diseases, such as Rheumatoid Arthritis (RA). This study aimed to explore the anti-inflammatory effects of curcumin on RA.
Materials and Methods: This double-blind clinical trial was carried out on 64 RA patients with an erythrocyte sedimentation rate (ESR)-Disease Activity Score (DAS)-28>2.6. The patients were then randomly divided into two groups of intervention and control. In addition to the routine treatment, the intervention group was treated with 80-mg/day capsules of curcumin (nano-micelles). Further, the patients were followed up for three months, and clinical-laboratory examinations were recorded in this study.
Results: There was no significant difference between the intervention and control groups regarding the trends of the disease activity indicators, including DAS-28, disability index, physician assessment, and the number of tender joints (P>0.05). Further, a significant difference was found between the two groups in terms of pain score changes and the number of swollen joints. Additionally, the curcumin-treated subjects obtained lower mean pain and fewer swollen joints, compared to those in the control group (P<0.05).
Conclusion: The present study revealed that curcumin had no significant therapeutic effects on reducing the activity of RA; however, no significant side effects were observed on the patients, and it also showed its analgesic effect well.
نوع مطالعه: کارآزمایی بالینی |
موضوع مقاله:
Clinical medicine
دریافت: 1401/5/27 | پذیرش: 1401/10/5 | انتشار: 1402/8/7
دریافت: 1401/5/27 | پذیرش: 1401/10/5 | انتشار: 1402/8/7
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