شنبه 1 دی 1403
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دوره 32، شماره 151 - ( 12-1402 )
جلد 32 شماره 151 صفحات 153-144 |
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Zamani M, Radahmadi M, Reisi P. Impact of Combined Forced Exercise with Escitalopram on Stress-Induced Depressive-Like Behavior in Male Rats. J Adv Med Biomed Res 2024; 32 (151) :144-153
URL: http://journal.zums.ac.ir/article-1-7283-fa.html
URL: http://journal.zums.ac.ir/article-1-7283-fa.html
Impact of Combined Forced Exercise with Escitalopram on Stress-Induced Depressive-Like Behavior in Male Rats. Journal of Advances in Medical and Biomedical Research. 1402; 32 (151) :144-153
چکیده: (246 مشاهده)
Background & Objective: The efficacy of escitalopram, a pharmaceutical antidepressant, and exercise, a lifestyle intervention, in mitigating depressive symptoms has been established. This study investigated the impact of varying doses of escitalopram and the combination of forced exercise with escitalopram on stress-induced depressive-like behavior in male rats.
Materials & Methods: Sixty-four male rats were allocated into eight groups: control (Co), sham (Sh), depression without treatment (Dep-WT), depression with exercise (Dep-Exe), depression with escitalopram at 10 mg/kg (Dep-Esc10), depression with escitalopram at 20 mg/kg (Dep-Esc20), depression with escitalopram at 10 mg/kg combined with exercise (Dep-Esc10-Exe), and depression with escitalopram at 20 mg/kg combined with exercise (Dep-Esc20-Exe). To induce depression, chronic restraint stress was administered for 6 hours per day over a period of 14 days.
Following the stress induction period, rats were administered escitalopram (at doses of 10 or 20 mg/kg, i.p), subjected to treadmill running (20-21 m/min for 1 h/day), or subjected to a combination of both interventions. Depressive-like behaviour induced by stress and locomotor activity were assessed using the forced swimming test (FST) and the open field test (OFT), respectively.
Results: In the FST, the immobility time significantly increased in the Dep-WT, Dep-Exe, and Dep-Esc10 groups, while it significantly decreased in the Dep-Esc20, Dep-Esc10-Exe, and Dep-Esc20-Exe groups compared to the Dep-WT group. In the OFT, the central time and total travelled distance significantly decreased in the Dep-WT group. Conversely, central time significantly increased in the Dep-Esc10-Exe and Dep-Esc20-Exe groups, and all treatment groups exhibited a significant increase in central time compared to the Dep-WT group.
Conclusion: The findings suggest that combining exercise with escitalopram yields additive effects, representing a promising treatment protocol for anxiety, depression, and locomotor activity.
Materials & Methods: Sixty-four male rats were allocated into eight groups: control (Co), sham (Sh), depression without treatment (Dep-WT), depression with exercise (Dep-Exe), depression with escitalopram at 10 mg/kg (Dep-Esc10), depression with escitalopram at 20 mg/kg (Dep-Esc20), depression with escitalopram at 10 mg/kg combined with exercise (Dep-Esc10-Exe), and depression with escitalopram at 20 mg/kg combined with exercise (Dep-Esc20-Exe). To induce depression, chronic restraint stress was administered for 6 hours per day over a period of 14 days.
Following the stress induction period, rats were administered escitalopram (at doses of 10 or 20 mg/kg, i.p), subjected to treadmill running (20-21 m/min for 1 h/day), or subjected to a combination of both interventions. Depressive-like behaviour induced by stress and locomotor activity were assessed using the forced swimming test (FST) and the open field test (OFT), respectively.
Results: In the FST, the immobility time significantly increased in the Dep-WT, Dep-Exe, and Dep-Esc10 groups, while it significantly decreased in the Dep-Esc20, Dep-Esc10-Exe, and Dep-Esc20-Exe groups compared to the Dep-WT group. In the OFT, the central time and total travelled distance significantly decreased in the Dep-WT group. Conversely, central time significantly increased in the Dep-Esc10-Exe and Dep-Esc20-Exe groups, and all treatment groups exhibited a significant increase in central time compared to the Dep-WT group.
Conclusion: The findings suggest that combining exercise with escitalopram yields additive effects, representing a promising treatment protocol for anxiety, depression, and locomotor activity.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Life science
دریافت: 1402/4/6 | پذیرش: 1402/11/24 | انتشار: 1402/12/12
دریافت: 1402/4/6 | پذیرش: 1402/11/24 | انتشار: 1402/12/12
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