دوره 33، شماره 156 - ( 12-1403 )                   جلد 33 شماره 156 صفحات 67-60 | برگشت به فهرست نسخه ها

Ethics code: IR.MEDSAB.REC.1398.124

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Asadi S S, Amiri P, Khatib A, Ebrahimi M A, Shahrestani S, Ghorat F. The Impact of Topical Alpinia Galanga L. Oil versus Diclofenac Gel on Symptoms of Knee Osteoarthritis: A Randomized Clinical Trial. J Adv Med Biomed Res 2025; 33 (156) :60-67
URL: http://journal.zums.ac.ir/article-1-7506-fa.html
The Impact of Topical Alpinia Galanga L. Oil versus Diclofenac Gel on Symptoms of Knee Osteoarthritis: A Randomized Clinical Trial. Journal of Advances in Medical and Biomedical Research. 1403; 33 (156) :60-67

URL: http://journal.zums.ac.ir/article-1-7506-fa.html

The Impact of Topical Alpinia Galanga L. Oil versus Diclofenac Gel on Symptoms of Knee Osteoarthritis: A Randomized Clinical Trial
چکیده:   (228 مشاهده)

Background and Aims: Knee osteoarthritis (OA) is a degenerative joint condition characterized by pain, stiffness, and reduced function, often requiring long-term management. Systemic complications associated with oral NSAIDs have led to increased interest in topical treatments. This study aimed to compare the efficacy of topical Alpinia galanga oil and diclofenac gel in relieving knee OA symptoms.
Methods: The present clinical trial was carried out from December 2021 to May 2022 on clients in health centers of Sabzevar, northeastern Iran. A total of 160 patients aged 45–70 years participated in this study. They were affected by knee OA based on the American College of Rheumatology criteria. Their condition was graded 1 to 3 based on the Kellgren-Lawrence classification system. The patients were randomly assigned to either receive Alpinia galanga L. oil (5–10 drops, bid) or 1% diclofenac gel, applied topically for 28 consecutive days. The findings, including pain severity, joint rigidity, motor acts, exercise ability, and quality of life, were examined at baseline, 14 days, and 28 days post-treatment via the WOMAC questionnaire. Balanced block randomization confirmed equal group assignment, and all patients, researchers, and statistical analysts were blinded to assignments of patients to groups. Data were analyzed using SPSS16, with t-tests and ANOVA employed to determine within-group and between-group differences (P < 0.05).
Results: Out of 160 patients, 81 were given Alpinia galanga oil and 77 received diclofenac gel. Both treatments significantly ameliorated pain acuity, joint rigidity, and motor act scores during the intervention period (P<0.001 for all). Exercise stamina was also fostered significantly in either group (P<0.001) without any significant disparity between treatments (P>0.05). Scores of quality of life were enhanced significantly in the Alpinia galanga oil group (P<0.001), while no significant change was observed in the diclofenac group (P=0.139). Finally, no statistically significant difference was found between groups in initial results suggesting comparable efficacy.
Conclusion: Topical Alpinia galanga oil is as effective as diclofenac gel in alleviating knee OA symptoms, with potential advantages in improving quality of life.

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نوع مطالعه: مقاله پژوهشی | موضوع مقاله: Clinical Medicine
دریافت: 1403/6/13 | پذیرش: 1403/10/23 | انتشار: 1403/12/23
فهرست منابع
1. Yao Q, Wu X, Tao C, Gong W, Chen M, Qu M, et al. Osteoarthritis: pathogenic signaling pathways and therapeutic targets. Signal Transduct Target Ther. 2023;8(1):56. [DOI:10.1038/s41392-023-01330-w] [PMID] [PMCID]
2. Vahdatpour B, Baradaran Mahdavi S, Arzaghi S, Haghighat S, Sadegh MM. The effectiveness of elaeagnus angustifolia versus curcumin in osteoarthritis of the Knee-A Triple-Blind Randomized Clinical Trial. J Isfahan Med Sch. 2022;40(681):563-70.
3. Vos T, Lim SS, Abbafati C, Abbas KM, Abbasi M, Abbasifard M, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396(10258):1204-22.
4. Litwic A, Edwards MH, Dennison EM, Cooper C. Epidemiology and burden of osteoarthritis. Br Med Bull. 2013;105(1):185-99. [DOI:10.1093/bmb/lds038] [PMID] [PMCID]
5. Katz JN, Arant KR, Loeser RF. Diagnosis and treatment of hip and knee osteoarthritis: a review. JAMA. 2021;325(6):568-78. [DOI:10.1001/jama.2020.22171] [PMID] [PMCID]
6. Minnig MC, Golightly YM, Nelson AE. Epidemiology of osteoarthritis: literature update 2022–2023. Curr Opin Rheumatol. 2024;36(2):108-12. [DOI:10.1097/BOR.0000000000000985] [PMID] [PMCID]
7. Abdel Shaheed C, Ferreira GE, Dmitritchenko A, McLachlan AJ, Day RO, Saragiotto B, et al. The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews. Med J Aust. 2021;214(7):324-31. [DOI:10.5694/mja2.50992] [PMID]
8. Darestani RT, Bakhshi H, Sahraee R. Comparing the efficacy and safety of Diclofenac and Piascledine in patients with knee osteoarthritis. Pajoohandeh J. 2013;17(6):272-8.
9. Machado GC, Abdel-Shaheed C, Underwood M, Day RO. Non-steroidal anti-inflammatory drugs (NSAIDs) for musculoskeletal pain. BMJ. 2021;104:372. [DOI:10.1136/bmj.n104] [PMID]
10. Richard MJ, Driban JB, McAlindon TE. Pharmaceutical treatment of osteoarthritis. Osteoarthr Cartil. 2023;31(4):458-66. [DOI:10.1016/j.joca.2022.11.005] [PMID]
11. Bariguian Revel F, Fayet M, Hagen M. Topical diclofenac, an efficacious treatment for osteoarthritis: a narrative review. Rheumatol Ther. 2020;7(2):217-36. [DOI:10.1007/s40744-020-00196-6] [PMID] [PMCID]
12. Huang H, Luo M, Liang H, Pan J, Yang W, Zeng L, et al. Meta-analysis comparing celecoxib with diclofenac sodium in patients with knee osteoarthritis. Pain Med. 2021;22(2):352-62. [DOI:10.1093/pm/pnaa230] [PMID] [PMCID]
13. Ghorat F, Sepidarkish M, Saadattalab F, Rezghi M, Shahrestani S, Gholamalizadeh M, et al. The clinical efficacy of Olibanum gum chewing in patients with Mild‐to‐Moderate Alzheimer disease: A randomized Parallel‐Design controlled trial. Neuropsychopharmacol Rep. 2024;44(1):109-14. [DOI:10.1002/npr2.12398] [PMID] [PMCID]
14. Azizkhani M, Dastjerdi MV, Arani MT, Pirjani R, Sepidarkish M, Ghorat F, Karimi M. Traditional dry cupping therapy versus medroxyprogesterone acetate in the treatment of idiopathic menorrhagia: a randomized controlled trial. Iran Red Crescent Med J. 2018;20(2):e60508. [DOI:10.5812/ircmj.60508]
15. Zargari A. Medicinal plants. Tehran, Iran: Tehran University Press, 2019; pp. 559-60.
16. Ramanunny AK, Wadhwa S, Gulati M, Vishwas S, Khursheed R, Paudel KR, et al. Journey of Alpinia galanga from kitchen spice to nutraceutical to folk medicine to nanomedicine. J Ethnopharmacol. 2022;291:115144. [DOI:10.1016/j.jep.2022.115144] [PMID]
17. Kojima-Yuasa A, Matsui-Yuasa I. Pharmacological effects of 1′-Acetoxychavicol acetate, a major constituent in the Rhizomes of Alpinia galanga and Alpinia conchigera. J Med Food. 2020;23(5):465-75. [DOI:10.1089/jmf.2019.4490] [PMID]
18. Cahyono B, Suzery M, Amalina ND. Anti-inflammatory effect of Alpinia galanga extract on acute inflammatory cell model of peripheral blood mononuclear cells stimulated with TNF-α. Med Glas (Zenica). 2023;20(2). [DOI:10.17392/1561-23]
19. Ge X, Liang Q, Long Y, Shen H, Zhang Q, Sun Z, Li W. Assessment of fresh Alpinia galanga (A. galanga) drying techniques for the chemical composition of essential oil and its antioxidant and biological activity. Food Chem. 2022; 30; 392:133314. [DOI:10.1016/j.foodchem.2022.133314] [PMID]
20. Syahruddin AN, Dahlan CK, Taslim NA. The effects of Kaempferia galanga L. extract on pain, stiffness and functional physic in patient with knee osteoarthritis: double blind randomized clinical trial. Int J Sci Healthc Res. 2017;2(4):37-43.
21. Kingsbury SR, Tharmanathan P, Keding A, Watt FE, Scott DL, Roddy E, Birrell F, et al. Pain Reduction with Oral Methotrexate in Knee Osteoarthritis: A Randomized, Placebo-Controlled Clinical Trial. Ann Intern Med. 2024;177(9):1145-56. [DOI:10.7326/M24-0303] [PMID]
22. Messier SP, Mihalko SL, Beavers DP, Nicklas BJ, DeVita P, Carr JJ, et al. Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial. JAMA. 2021;325(7):646-57. [DOI:10.1001/jama.2021.0411] [PMID] [PMCID]
23. Umar MI, Asmawi MZ, Sadikun A, Majid AM, Al-Suede FS, Hassan LE,et al. Ethyl-p-methoxycinnamate isolated from Kaempferia galanga inhibits inflammation by suppressing interleukin-1, tumor necrosis factor-α, and angiogenesis by blocking endothelial functions. Clinics. 2014;69(2):134-44. [DOI:10.6061/clinics/2014(02)10] [PMID]
24. Phitak T, Choocheep K, Pothacharoen P, Pompimon W, Premanode B, Kongtawelert P. The effects of p-hydroxycinnamaldehyde from Alpinia galanga extracts on human chondrocytes. Phytochemistry. 2009;70(2):237-43. [DOI:10.1016/j.phytochem.2008.11.010] [PMID]
25. Yip YB, Tam AC. An experimental study on the effectiveness of massage with aromatic ginger and orange essential oil for moderate-to-severe knee pain among the elderly in Hong Kong. Complement Ther Med. 2008;16(3):131-8. [DOI:10.1016/j.ctim.2007.12.003] [PMID]
26. Baek HI, Shen L, Ha KC, Park YK, Kim CS, Kwon JE, et al. Effectiveness and safety of steamed ginger extract on mild osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Food Funct. 2024;15(18):9512-23. [DOI:10.1039/D4FO01640H] [PMID]
27. Feng F, Fang Y, Chen RG, Yan BH, Huang Y, Wu B, et al. Randomized, double-blind, parallel controlled, multicenter clinical trial of effectiveness and safety of Shexiang Zhuifeng Zhitong Ointment in alleviating pain in knee osteoarthritis (syndrome of cold-dampness obstruction). Zhongguo Zhongyao Zazhi= China Journal of Chinese Materia Medica. 2024;49(9):2512-21.
28. Setty AR, Sigal LH. Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects. In Seminars in arthritis and rheumatism. Vol. 34. No. 6. 2005. Philadelphia, Pennsylvania, United States: WB Saunders. pp. 773-84. [DOI:10.1016/j.semarthrit.2005.01.011] [PMID]
29. Ramezani M, Nekozad N. Comparison between the effectiveness of glucosamine sulfate and zintoma on clinical improvement of knee osteoarthritis. Ebnesina. 2011;14(3):29-34.
30. Niempoog S, Pawa KK, Amatyakul C. The efficacy of powdered ginger in osteoarthritis of the knee. J Med Assoc Thai. 2012;95(Suppl 1):S59-64.
31. Azizi F, Ghorat F, Rakhshani MH, Rad M. Comparison of the effect of topical use of Nigella Sativa oil and diclofenac gel on osteoarthritis pain in older people: A randomized, double-blind, clinical trial. J Herb Med. 2019;16:100259. [DOI:10.1016/j.hermed.2019.100259]
32. Bee TA, Liew A. Dietary supplements used in osteoarthritis. Proc Singap Healthc. 2010;19(3):237-47. [DOI:10.1177/201010581001900310]
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