یکشنبه 3 اسفند 1404
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دوره 33، شماره 161 - ( 9-1404 )
جلد 33 شماره 161 صفحات 306-293 |
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Jha A K, Almoyad M A A, Wahab S, Gupta G, Goh K W, Sahebkar A et al . Computational Identification of Dysregulated Genes and Pathways in Non-Small Cell Lung Cancer: A Systems Biology Approach. J Adv Med Biomed Res 2025; 33 (161) :293-306
URL: http://journal.zums.ac.ir/article-1-7825-fa.html
URL: http://journal.zums.ac.ir/article-1-7825-fa.html
Computational Identification of Dysregulated Genes and Pathways in Non-Small Cell Lung Cancer: A Systems Biology Approach. Journal of Advances in Medical and Biomedical Research. 1404; 33 (161) :293-306
چکیده: (232 مشاهده)
Background & Objective: Non-small cell lung cancer (NSCLC) stands as the predominant subtype of lung malignancy globally, which persists as a major driver of cancer-related deaths. This study systematically investigates bioinformatics-based investigations aimed at identifying differentially expressed genes (DEGs) and potential therapeutic targets associated with NSCLC.
Materials & Methods: Publicly available RNA expression datasets were analyzed using advanced in silico tools, including the enrichr function from the GSEApy package and R statistical software (v4.3.1), to uncover molecular pathways involved in disease progression. Key oncogenic signaling pathways such as TGF-β signaling, Wnt/β-catenin, PI3K-AKT-mTOR, and MAPK were found to be significantly associated with several genes, such as AGER, ANK3, CSTA, FGG, AGR2, BRCA1, HDAC1, miR-577, TRIM29, PIK3CA, and JNK. Pathway enrichment analysis further identified significant involvement in chronic myeloid leukemia, longevity regulation, thyroid hormone signaling, viral carcinogenesis, Epstein-Barr virus infection, and microRNAs in cancer.
Results: The correlation analysis revealed that TRIM29 expression was higher in control samples, whereas AGR2 was prominently expressed in NSCLC samples. Additionally, HDAC1 and BRCA1 were identified as promising diagnostic biomarkers.
Conclusion: These findings improve our comprehension of NSCLC disease mechanisms while identifying promising molecular candidates for formulating more potent, customized treatment approaches, potentially improving clinical outcomes for patients.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Life Science
دریافت: 1404/5/25 | پذیرش: 1404/8/20 | انتشار: 1404/9/21
دریافت: 1404/5/25 | پذیرش: 1404/8/20 | انتشار: 1404/9/21
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