Background and aims: Coronavirus Disease 2019 (COVID-19) has different fatality rate and clinical effects. Genetic polymorphism is one of the factors impacting COVID-19 outcome. Variants of the IFNL4 gene have been linked to the clinical response to some viral infections. Many studies found the correlation between T Allele of IFNL4 (rs12979860) SNP and COVID-19 outcome. Our goal was to investigate the correlation between such polymorphism with severity of COVID-19 infection.
Methods and results: A total of 150 COVID-19 patients (75 severe, 75 mild/moderate) were enrolled in present study. Tagman real-time PCR were used in this study.
Results: TT genotype of rs12979860 variants was significantly prevalent in severe patients compare to mild and moderate infection patients.
Conclusions: Between the two study groups, there is a statistically significant connection between the COVID-19 outcome and the T Allele of  IFNL4 (rs12979860) SNP.