دوره 33، شماره 162 - ( Special Issue 1404 )                   جلد 33 شماره 162 صفحات 97-88 | برگشت به فهرست نسخه ها

XML English Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Saleh A A, Sahab K S. Investigation of the Association between Chemerin, Resistin, and Selected Cardiac Enzymes in Patients with Acute Myocardial Infarction. J Adv Med Biomed Res 2025; 33 (162) :88-97
URL: http://journal.zums.ac.ir/article-1-7890-fa.html
Investigation of the Association between Chemerin, Resistin, and Selected Cardiac Enzymes in Patients with Acute Myocardial Infarction. Journal of Advances in Medical and Biomedical Research. 1404; 33 (162) :88-97

URL: http://journal.zums.ac.ir/article-1-7890-fa.html

Investigation of the Association between Chemerin, Resistin, and Selected Cardiac Enzymes in Patients with Acute Myocardial Infarction
چکیده:   (164 مشاهده)

Background & Objective: Myocardial infarction (MI), commonly known as a heart attack, refers to the irreversible necrosis of cardiac muscle cells due to insufficient oxygen delivery resulting from reduced or obstructed coronary blood flow. Severe myocardial cell loss is a major cause of mortality in MI patients. Inflammatory markers such as chemerin and resistin, alongside cardiac enzymes, may play a key role in MI diagnosis and monitoring. This study aimed to evaluate the clinical significance of inflammatory markers (chemerin and resistin) and cardiac enzymes, including lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase-MB (CK-MB), and cardiac troponin I, by assessing their serum levels in patients with myocardial infarction compared to healthy controls.
 Materials & Methods: A total of 120 subjects participated in this study. Sixty were MI patient’s diagnosed based on clinical presentation, symptoms, and electrocardiogram (ECG) findings, with a mean age of 59.31 ± 1.64 years. The remaining 60 were healthy control subjects with a mean age of 37.30 ± 2.10 years. The study was conducted in the Cardiac Care Unit of Baqubah Teaching Hospital, Diyala Governorate, Iraq. Serum levels of chemerin, resistin, troponin I, LDH, CK-MB, and AST were measured and statistically analyzed.
Results:  This study was conducted in Cardiac Care Unit of Baqubah Teaching Hospital in Diyala governorate, Iraq. The study revealed a significant decrease (P < 0.001) in the serum levels of chemerin and resistin among MI patients compared to controls. Conversely, there was a significant increase (P < 0.001) in troponin I, LDH, CK-MB, and AST levels. Additionally, overweight MI patients exhibited significantly higher levels (P < 0.001) of troponin I, chemerin, and resistin compared with normal-weight MI patients.
Conclusion:  Chemerin and resistin levels significantly decreased following admission and treatment in MI patients, suggesting that these inflammatory markers may serve as potential indicators of therapeutic response in myocardial infarction management.

متن کامل [PDF 468 kb]   (8 دریافت)    
نوع مطالعه: مقاله پژوهشی | موضوع مقاله: Health Improvement Strategies
دریافت: 1404/7/12 | پذیرش: 1404/8/17 | انتشار: 1404/10/8
فهرست منابع
1. Reindl M, Reinstadler SJ, Feistritzer HJ, Mayr A, Klug G, Marschang P, et al. Acute myocardial infarction as a manifestation of systemic vasculitis. Wien Klin Wochenschr. 2016;128(21-22):841-3. [DOI:10.1007/s00508-016-1051-4] [PMID]
2. Haasenritter J, Stanze D, Widera G, Wilimzig C, Abu Hani M, Sonnichsen AC, et al. Does the patient with chest pain have a coronary heart disease? Diagnostic value of single symptoms and signs--a meta-analysis. Croat Med J. 2012;53(5):432-41. [DOI:10.3325/cmj.2012.53.432] [PMID] [PMCID]
3. Liakos M, Parikh PB. Gender Disparities in Presentation, Management, and Outcomes of Acute Myocardial Infarction. Curr Cardiol Rep. 2018;20(8):64. [DOI:10.1007/s11886-018-1006-7] [PMID]
4. Aydin S, Aydin S. Irisin Concentrations as a Myocardial Biomarker. 2016. pp. 489-504. [DOI:10.1007/978-94-007-7678-4_3]
5. Yao G, Su G, Li K, Li B, Dong H. Comparative study of ticagrelor and clopidogrel in therapeutic effect of acute myocardial infarction patients undergoing percutaneous coronary intervention. Saudi J Biol Sci. 2017;24(8):1818-20. [DOI:10.1016/j.sjbs.2017.11.020] [PMID] [PMCID]
6. Anjuman G, Muhammad A, Abdullah A. Changes in Inflammatory Markers Concentration in Diabetic and Non-diabetic Patients with Myocardial Infarction. Adv Biores. 2013;3:73.
7. O'Gara PT, Kushner FG, Ascheim DD, Casey DE, Jr., Chung MK, de Lemos JA, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;127(4):e362-425.
8. Hamad MS, Sarhat ER, Sarhat TR, Abass KS. Impact of serum Adropin and Irisin in Iraqi patients with congestive heart failure. Pak J Med Health Sci. 2021;15(2):497-9.
9. Boeddinghaus J, Reichlin T, Nestelberger T, Twerenbold R, Meili Y, Wildi K, et al. Early diagnosis of acute myocardial infarction in patients with mild elevations of cardiac troponin. Clin Res Cardiol. 2017;106(6):457-67. [DOI:10.1007/s00392-016-1075-9] [PMID]
10. Shamil A. Evaluation of some biochemical parameters in serum of patients suffering from acute coronary syndrome. Tikrit: Tikrit University; 2018.
11. Saleem M. Determination of some biochemical marker levels in serum of patients with congestive heart failure, angina pectoris and myocardial infarction. Eng Technol J. 2012;30(6):939-49. [DOI:10.30684/etj.30.6.2]
12. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409(6818):307-12. [DOI:10.1038/35053000] [PMID]
13. Verma S, Li SH, Wang CH, Fedak PW, Li RK, Weisel RD, et al. Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Circulation. 2003;108(6):736-40. [DOI:10.1161/01.CIR.0000084503.91330.49] [PMID]
14. Calabro P, Samudio I, Willerson JT, Yeh ET. Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways. Circulation. 2004;110(21):3335-40. [DOI:10.1161/01.CIR.0000147825.97879.E7] [PMID]
15. Burnett MS, Lee CW, Kinnaird TD, Stabile E, Durrani S, Dullum MK, et al. The potential role of resistin in atherogenesis. Atherosclerosis. 2005;182(2):241-8. [DOI:10.1016/j.atherosclerosis.2005.02.014] [PMID]
16. Ohmori R, Momiyama Y, Kato R, Taniguchi H, Ogura M, Ayaori M, et al. Associations between serum resistin levels and insulin resistance, inflammation, and coronary artery disease. J Am Coll Cardiol. 2005;46(2):379-80. [DOI:10.1016/j.jacc.2005.04.022] [PMID]
17. Pischon T, Bamberger CM, Kratzsch J, Zyriax BC, Algenstaedt P, Boeing H, et al. Association of plasma resistin levels with coronary heart disease in women. Obes Res. 2005;13(10):1764-71. [DOI:10.1038/oby.2005.215] [PMID]
18. Brewster LM. Creatine kinase, energy reserve, and hypertension: from bench to bedside. Ann Transl Med. 2018;6(15):292. [DOI:10.21037/atm.2018.07.15] [PMID] [PMCID]
19. Khalil OA, Ramadan KS, Hamza AH, El-Toukhy SE. Association of plasma protein C levels and coronary artery disease in men. Afr J Biotechnol. 2013;12(50):6986.
20. Zahid ZI, Shad MA, Sheikh MA, Nawaz H. Occupational Exposure to Industrial Pollution Elevates the Levels of Myocardial Enzymes: A Leading Cause of Cardiovascular Abnormalities in Industrial Workers. Pak J Life Soc Sci. 2018;16(1):36.
21. Bodor GS. Biochemical Markers of Myocardial Damage. EJIFCC. 2016;27(2):95-111. [PMID] [PMCID]
22. Herová M, Schmid M, Gemperle C, Loretz C, Hersberger M. Low dose aspirin is associated with plasma chemerin levels and may reduce adipose tissue inflammation. Atherosclerosis. 2014;235(2):256-62. [DOI:10.1016/j.atherosclerosis.2014.05.912] [PMID]
23. Zangana SN, Al-Tawil NG. Role of Cardiac Troponin I Level in Predicting in Hospital Outcomes in Patients with ST-segment Elevation Myocardial Infarction in Erbil-Iraq. Diyala J Med. 2017;13(1):1-7. [DOI:10.26505/DJM.13013150123]
24. Allwsh TA, Aziz NM. Clinical study of copeptin in serum patiants of heart diseases. Tikrit J Pure Sci. 2015;20(3):99-107.
25. Chakaroun R, Raschpichler M, Klöting N, Oberbach A, Flehmig G, Kern M, et al. Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity. Metabolism. 2012;61(5):706-14. [DOI:10.1016/j.metabol.2011.10.008] [PMID]
26. Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016;37(3):267-315. [DOI:10.1093/eurheartj/ehv320] [PMID]
27. Amsterdam EA, Wenger NK, Brindis RG, Casey DE, Jr., Ganiats TG, Holmes DR, Jr., et al. 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;64(24):e139-e228. [DOI:10.1016/j.jacc.2014.09.017] [PMID]
28. Licka M, Zimmermann R, Zehelein J, Dengler TJ, Katus HA, Kübler W. Troponin T concentrations 72 hours after myocardial infarction as a serological estimate of infarct size. Heart. 2002;87(6):520-4. [DOI:10.1136/heart.87.6.520] [PMID] [PMCID]
29. Dera AA, Algamdi B, Ahmad I, Shahrani MA, Alraey Y, Hashlan I, et al. Association of serum leptin and resistin levels among obese Saudi patients with acute myocardial infarction in Asir region. Cell Mol Biol (Noisy-le-grand). 2023;69(6):1-7. [DOI:10.14715/cmb/2023.69.6.1] [PMID]
30. Wang B, Kou W, Ji S, Shen R, Ji H, Zhuang J, et al. Prognostic value of plasma adipokine chemerin in patients with coronary artery disease. Front Cardiovasc Med. 2022;9:968349. [DOI:10.3389/fcvm.2022.968349] [PMID] [PMCID]
31. Abdullah AA, Zangana SN. Correlation between body mass index and in-hospital mortality in patients with ST-segment elevation myocardial infarction in Erbil city-Iraq. Diyala Journal of Medicine. 2021;21(1):35-43. [DOI:10.26505/DJM.21015930222]
32. Baig M, Alghalayini KW, Gazzaz ZJ, Atta H. Association of Serum Omentin-1, Chemerin, and Leptin with Acute Myocardial Infarction and its Risk Factors. Pak J Med Sci. 2020;36(6):1183-8. [DOI:10.12669/pjms.36.6.2372] [PMID] [PMCID]
33. Piestrzeniewicz K, Łuczak K, Komorowski J, Maciejewski M, Jankiewicz Wika J, Goch JH. Resistin increases with obesity and atherosclerotic risk factors in patients with myocardial infarction. Metabolism. 2008;57(4):488-93. [DOI:10.1016/j.metabol.2007.11.009] [PMID]
34. Helmi S, Alissa E, Abdulrafee A, Al-Ama N. The association of serum chemerin level with risk of subclinical atherosclerosis in Saudi patients. Pak J Med Sci. 2020;36(6):1191-6.
بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Journal of Advances in Medical and Biomedical Research می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2026 CC BY-NC 4.0 | Journal of Advances in Medical and Biomedical Research

Designed & Developed by : Yektaweb