سه شنبه 19 خرداد 1405
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دوره 33، شماره 162 - ( Special Issue 1404 )
جلد 33 شماره 162 صفحات 122-110 |
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Kadhim Z Y, Al-khafaji S A, Mankhi R N, Abddulameer M A. Design, Synthesis, In Silico Studies, and Pharmacological Evaluation of New Chalcone Derivatives as Anticancer and Antioxidant Agents. J Adv Med Biomed Res 2025; 33 (162) :110-122
URL: http://journal.zums.ac.ir/article-1-7909-fa.html
URL: http://journal.zums.ac.ir/article-1-7909-fa.html
Design, Synthesis, In Silico Studies, and Pharmacological Evaluation of New Chalcone Derivatives as Anticancer and Antioxidant Agents. Journal of Advances in Medical and Biomedical Research. 1404; 33 (162) :110-122
چکیده: (253 مشاهده)
Background & Objective: Chalcones are promising compounds in the pharmaceutical field due to their antioxidant and anticancer properties. The aim of this study was to synthesize two novel chalcone derivatives (A1 and A2) and evaluate their biological activities, including antioxidant potential and cytotoxicity against cancer cells.
Materials & Methods: The chemical structures of compounds A1 and A2 were confirmed using spectroscopic techniques including Proton Nuclear Magnetic Resonance (1H-NMR), Gas Chromatography-Mass Spectrometry (GC-MS), and Ultraviolet-Visible (UV-Vis) spectroscopy. A hemolysis assay was conducted to assess biocompatibility. Antioxidant activity was measured using the DPPH radical scavenging assay at various concentrations (12.4-1000µg/ml). Cytotoxicity was evaluated against human breast cancer cells (MCF-7).
Results: Both A1 and A2 exhibited low hemolytic activity (4.09% and 3.99% respectively, at 100µg/ml), indicating good biocompatibility. Compound A1 exhibited more potent antioxidant activity than A2. Cytotoxicity assays demonstrated that both compounds were more toxic to MCF-7 cancer cells, with IC50 values for the produced compounds A1, A2, and Tamoxifen were 34.67µg/ml, 28.34µg/ml, and 15.48µg/ml, respectively, indicating potential selective anticancer activity.
Conclusion: Compounds A1 and A2 exhibited promising antioxidant and anticancer properties, with minimal hemolytic effects and selective toxicity toward cancer cells, making them potential candidates for further pharmaceutical development.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Pharmacology
دریافت: 1404/7/16 | پذیرش: 1404/8/28 | انتشار: 1404/10/8
دریافت: 1404/7/16 | پذیرش: 1404/8/28 | انتشار: 1404/10/8
فهرست منابع
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