Volume 28, Issue 131 (November & December 2020)                   J Adv Med Biomed Res 2020, 28(131): 330-334 | Back to browse issues page

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Pouranian M, Rohani M, Emamikhah M, Shahidi G, Ramezani Ghamsari M, Babaie M, et al . Comparison of the Blink Reflex and R2 Recovery Cycle Parameters Between Blepharospasm and Healthy Subjects. J Adv Med Biomed Res 2020; 28 (131) :330-334
URL: http://journal.zums.ac.ir/article-1-6045-en.html
Comparison of the Blink Reflex and R2 Recovery Cycle Parameters Between Blepharospasm and Healthy Subjects
Maryam Pouranian1 , Mohammad Rohani1 , Maziar Emamikhah1 , Gholamali Shahidi1 , Mona Ramezani Ghamsari1 , Mahla Babaie2 , Mansoureh Babadi3 , Mahdi Safdarian4 , Seyed Amir Hassan Habibi * 5
1- Dept. of Neurology, Rasoul Akram Hospital, Iran University of Medical Science, Tehran, Iran
2- Student Research Committee, Iran University of Medical Science, Tehran, Iran
3- tudent Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
4- Student Research Committee, Tehran University of Medical Science, Tehran, Iran
5- Dept. of Neurology, Rasoul Akram Hospital, Iran University of Medical Science, Tehran, Iran , Habibi.sah@iums.ac.ir
Abstract:   (146365 Views)

 Background & Objective:  The blink reflex recovery cycle indicates the excitability of interneurons in the brainstem. In this study, we aimed to investigate the blink reflex and R2 recovery cycle in patients with benign essential blepharospasm (BEB).
 Materials & Methods:  This prospective case-control study compared the blink reflex and R2 recovery in 18 BEB patients with 18 age- and gender-matched healthy individuals. The blink reflex was measured in a stimulation duration of 0.2 ms, and R1, R2, and R2’ were recorded for all subjects. The R2 recovery cycle was measured by stimulation of the supraorbital nerve at four interstimulus intervals (ISI) of 200, 300, 500, and 1000 ms, with the same intensity as the previous test. The R2 recovery index was calculated and compared with the control group via independent sample t-test. Two-tailed P-value less than 0.05 was considered statistically significant.
 Results:  The blink reflex (R1, R2, and R2’ responses) distal latencies and amplitudes in the BEB group were not significantly different from the control group (P>0.05). The R2 recovery index in all intervals was significantly higher in the BEB group than the control group (P=0.00). The most significant difference between the BEB and control groups regarding the R2 recovery indices was observed at ISIs of 300 and 200 ms (80.36 vs. 16.99 and 75.70 vs. 12.57, respectively). There was a negative correlation between the patient’s age at the onset of disease and the R2 recovery index; however, it was not statistically significant (P>0.05).
 Conclusion:  Our findings showed that the R2 recovery reflex was higher in BEB patients than the normal population. Therefore, it can be a helpful index for differentiating BEB cases from psychogenic or malingering ones.

Keywords: Blepharospasm, Blink reflex, R2 recovery cycle
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✅ Our findings showed that the R2 recovery reflex was higher in BEB patients than the normal population. Therefore, it can be a helpful index for differentiating BEB cases from psychogenic or malingering ones.


Type of Study: Original Article | Subject: Clinical medicine
Received: 2020/06/2 | Accepted: 2020/08/12 | Published: 2020/12/30
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