پنجشنبه 4 اردیبهشت 1404
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دوره 32، شماره 155 - ( 8-1403 )
جلد 32 شماره 155 صفحات 465-458 |
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Safari T, Shoghi E, Niazi A A, Niyazi P, Bagheri H, Vahedi M M, et al . Magnesium Sulfate and Moderate-Intensity Training Improve Lithium-Induced Liver Injury in Male Rats. J Adv Med Biomed Res 2024; 32 (155) :458-465
URL: http://journal.zums.ac.ir/article-1-7448-fa.html
URL: http://journal.zums.ac.ir/article-1-7448-fa.html
Magnesium Sulfate and Moderate-Intensity Training Improve Lithium-Induced Liver Injury in Male Rats. Journal of Advances in Medical and Biomedical Research. 1403; 32 (155) :458-465
چکیده: (169 مشاهده)
Background & Objective: Liver damage is a common complication of lithium (Li). The present study investigates the preventive role of MgSo4 and moderate-intensity training MIT on Li hepatotoxicity in male rats.
Materials & Methods: Seventy-two male rats were distributed into 12 groups, control, Li10 mg/kg/day/ip, MgSo4 80 mg/kg/day/ip; MIT; Li40 mg/kg/day/ip; Li10+MgSo4; Li10+MIT; Li10+MgSo4+MIT, MgSo4+MIT, Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT. All animals were under the exercise protocol for 6 weeks and received the drugs daily. Then, a blood sample was taken from the heart to measure Cholesterol, Triglyceride, LDL, HDL, AST, and ALT. The liver was excised and then put in 10% formalin to be sent to the lab for pathological investigations.
Results: Compared to the control group, Li 10 and 40 mg/kg cause severe liver injury, p<0.05. Instead, MgSo4 and 6 weeks of MIT (Li10+MgSo4, Li10+MIT, and Li10+MgSo4+MIT), Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT, in comparison with Li10mg/kg and Li40 mg/kg, reduces damage and improves the liver function, p<0.05.
Conclusion: MgSo4 and exercise reduce Li-related, improved integrity together with liver function.
Materials & Methods: Seventy-two male rats were distributed into 12 groups, control, Li10 mg/kg/day/ip, MgSo4 80 mg/kg/day/ip; MIT; Li40 mg/kg/day/ip; Li10+MgSo4; Li10+MIT; Li10+MgSo4+MIT, MgSo4+MIT, Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT. All animals were under the exercise protocol for 6 weeks and received the drugs daily. Then, a blood sample was taken from the heart to measure Cholesterol, Triglyceride, LDL, HDL, AST, and ALT. The liver was excised and then put in 10% formalin to be sent to the lab for pathological investigations.
Results: Compared to the control group, Li 10 and 40 mg/kg cause severe liver injury, p<0.05. Instead, MgSo4 and 6 weeks of MIT (Li10+MgSo4, Li10+MIT, and Li10+MgSo4+MIT), Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT, in comparison with Li10mg/kg and Li40 mg/kg, reduces damage and improves the liver function, p<0.05.
Conclusion: MgSo4 and exercise reduce Li-related, improved integrity together with liver function.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Pharmacology
دریافت: 1402/12/7 | پذیرش: 1403/8/10 | انتشار: 1403/7/19
دریافت: 1402/12/7 | پذیرش: 1403/8/10 | انتشار: 1403/7/19
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