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Volume 32, Issue 155 (November & December 2024)
J Adv Med Biomed Res 2024, 32(155): 458-465 |
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Safari T, Shoghi E, Niazi A A, Niyazi P, Bagheri H, Vahedi M M, et al . Magnesium Sulfate and Moderate-Intensity Training Improve Lithium-Induced Liver Injury in Male Rats. J Adv Med Biomed Res 2024; 32 (155) :458-465
URL: http://journal.zums.ac.ir/article-1-7448-en.html
URL: http://journal.zums.ac.ir/article-1-7448-en.html
Tahereh Safari *1 
, Elham Shoghi2 , Abbas Ali Niazi , Parsa Niyazi3 , Hossein Bagheri4 , Mohamad Mahdi Vahedi5 , Rana Hashemi6 , Fateme Maghool7 , Mohadeseh Chahkandi8
, Elham Shoghi2 , Abbas Ali Niazi , Parsa Niyazi3 , Hossein Bagheri4 , Mohamad Mahdi Vahedi5 , Rana Hashemi6 , Fateme Maghool7 , Mohadeseh Chahkandi8
1- 8. School of medicine, Department of Physiology, PhD, Zahedan University of Medical Sciences, Zahedan, Iran , safaritahereh2@gmail.com
2- 1. School of Medicine, Department of Physiology, Master of Sport Sciences and exercise Physiology, Zahedan University of Medical Sciences, Zahedan, Iran, elhamshoghi2023@gmail.com, Mobile: +989223113929, ORCID:0009-0009-4651-414X
3- 3. School of Medicine, Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran, tz.parsa@yahoo.com, Mobile: +98 9379049 , ORCID:0009-0007-8878-3933
4- 4. Department of Medical English, Zahedan University of Medical Sciences, Iran lang_academy@yahoo.com, Mobile: +98915-54-8901, ORCID:0000-0002-9591-9399
5- 5. School of medicine, Department of Pharmaciligy, , Zahedan University of Medical Sciences,Zahedan,Iran, dr.mahdivahedi@gmail.com, ORCID: 0000-0002-2607-0715
6- 6. School of Medicine, Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran, ranahashemi@yahoo.com, Mobile: +98 915 541 7695, ORCID: 0000-0002-1736-8210
7- 7. Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, f.maghool@gmail.com, Mobile:+989152074423, ORCID:0000-0002-0845-4600
8- 8. Cellular and Molecular Research Center, Reserch Institute of Cellular, Zahedan University of Medical Sciences, Zahedan, Iran, m.chahkandi1365@gmail.com, Mobile:+989355961194, ORCID: 0000-0003-1847-248X
2- 1. School of Medicine, Department of Physiology, Master of Sport Sciences and exercise Physiology, Zahedan University of Medical Sciences, Zahedan, Iran, elhamshoghi2023@gmail.com, Mobile: +989223113929, ORCID:0009-0009-4651-414X
3- 3. School of Medicine, Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran, tz.parsa@yahoo.com, Mobile: +98 9379049 , ORCID:0009-0007-8878-3933
4- 4. Department of Medical English, Zahedan University of Medical Sciences, Iran lang_academy@yahoo.com, Mobile: +98915-54-8901, ORCID:0000-0002-9591-9399
5- 5. School of medicine, Department of Pharmaciligy, , Zahedan University of Medical Sciences,Zahedan,Iran, dr.mahdivahedi@gmail.com, ORCID: 0000-0002-2607-0715
6- 6. School of Medicine, Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran, ranahashemi@yahoo.com, Mobile: +98 915 541 7695, ORCID: 0000-0002-1736-8210
7- 7. Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, f.maghool@gmail.com, Mobile:+989152074423, ORCID:0000-0002-0845-4600
8- 8. Cellular and Molecular Research Center, Reserch Institute of Cellular, Zahedan University of Medical Sciences, Zahedan, Iran, m.chahkandi1365@gmail.com, Mobile:+989355961194, ORCID: 0000-0003-1847-248X
Abstract: (37 Views)
Background & Objective: Liver damage is a common complication of lithium (Li). The present study investigates the preventive role of MgSo4 and moderate-intensity training MIT on Li hepatotoxicity in male rats.
Materials & Methods: Seventy-two male rats were distributed into 12 groups, control, Li10 mg/kg/day/ip, MgSo4 80 mg/kg/day/ip; MIT; Li40 mg/kg/day/ip; Li10+MgSo4; Li10+MIT; Li10+MgSo4+MIT, MgSo4+MIT, Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT. All animals were under the exercise protocol for 6 weeks and received the drugs daily. Then, a blood sample was taken from the heart to measure Cholesterol, Triglyceride, LDL, HDL, AST, and ALT. The liver was excised and then put in 10% formalin to be sent to the lab for pathological investigations.
Results: Compared to the control group, Li 10 and 40 mg/kg cause severe liver injury, p<0.05. Instead, MgSo4 and 6 weeks of MIT (Li10+MgSo4, Li10+MIT, and Li10+MgSo4+MIT), Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT, in comparison with Li10mg/kg and Li40 mg/kg, reduces damage and improves the liver function, p<0.05.
Conclusion: MgSo4 and exercise reduce Li-related, improved integrity together with liver function.
Materials & Methods: Seventy-two male rats were distributed into 12 groups, control, Li10 mg/kg/day/ip, MgSo4 80 mg/kg/day/ip; MIT; Li40 mg/kg/day/ip; Li10+MgSo4; Li10+MIT; Li10+MgSo4+MIT, MgSo4+MIT, Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT. All animals were under the exercise protocol for 6 weeks and received the drugs daily. Then, a blood sample was taken from the heart to measure Cholesterol, Triglyceride, LDL, HDL, AST, and ALT. The liver was excised and then put in 10% formalin to be sent to the lab for pathological investigations.
Results: Compared to the control group, Li 10 and 40 mg/kg cause severe liver injury, p<0.05. Instead, MgSo4 and 6 weeks of MIT (Li10+MgSo4, Li10+MIT, and Li10+MgSo4+MIT), Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT, in comparison with Li10mg/kg and Li40 mg/kg, reduces damage and improves the liver function, p<0.05.
Conclusion: MgSo4 and exercise reduce Li-related, improved integrity together with liver function.
Type of Study: Original Article |
Subject:
Pharmacology
Received: 2024/02/26 | Accepted: 2024/10/31 | Published: 2024/10/10
Received: 2024/02/26 | Accepted: 2024/10/31 | Published: 2024/10/10
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