Syzygium aromaticum is the scientific name for the aromatic flower buds of an Indonesian native tree from the Myrtaceae family.  Cloves contain bioactive compounds such as caryophyllene, eugenol, and acetyl eugenol, which have been shown to possess various physiological properties, including antioxidant, antibacterial, analgesic, anti-inflammatory, anticancer, and anesthetic effects. The S. aromaticum extracts were methanol, ethanol, petroleum ether, hexane, and chloroform extracts. The antibacterial activity of S. aromaticum extracts was evaluated using the agar-well diffusion assay. Its efficacy was compared with the antibiotic and determined. This study was conducted to verify the antimicrobial activity of S. aromaticum against P. aeruginosa, indicating that S. aromaticum extract may have medicinal uses. S. aromaticum extracts at concentrations of 62.5 Mg.ml^-1, 125 Mg.ml^-1, and 500 Mg.ml^-1 were used. Phytochemical screening revealed the presence of tannins, flavonoids, terpenoids, alkaloids, phlobutanins, and saponins in the extracts. The ethanol extract showed the lowest activity against P. aeruginosa at various concentrations, with an inhibition zone of 24 mm at 500 Mg.ml^-1. The methanol extract showed the highest activity against P. aeruginosa, with an inhibition zone of 40 mm at 500 Mg.ml^-1. P. aeruginosa bacteria showed sensitivity to the antibiotics Gentamicin, Neomycin, Enrofloxacin, Imipenem, and Meropenem, but were resistant to Cefadroxil, Cephalexin, Ceftriaxone, Ciprofloxacin, and Sulfamethoxazole.