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1- 1- Cellular & Molecular Research Center, Faculty of Medicine ,Guilan University of Medical Sciences, Rasht
2- 1- Cellular & Molecular Research Center, Faculty of Medicine ,Guilan University of Medical Sciences, Rasht ,parvin.mma76@gmail.com
3- 4Dept. of Sport Physiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht ,Iran
4- Department of Medical Biotechnology, School of Paramedical Science, Guilan University of Medical Sciences, Rasht, Iran
2- 1- Cellular & Molecular Research Center, Faculty of Medicine ,Guilan University of Medical Sciences, Rasht ,
3- 4Dept. of Sport Physiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht ,Iran
4- Department of Medical Biotechnology, School of Paramedical Science, Guilan University of Medical Sciences, Rasht, Iran
Abstract: (6 Views)
Objective: Metabolic syndrome (MS) is one of the most common disorders in post-menopausal women, which lacks effective, and safe treatment. The bioflavonoid of Hesperidin (Hsp) has beneficial effects in different disorders like cancer and cardiovascular disorders. This study aimed to investigate the interactive effect of supplementation with Hsp and 8-weeks moderate-intensity continuous training (MICT) on insulin resistance, body weight and dyslipidemia in a menopause-induced MS model in rats.
Methods: A total of 40 ovariectomized (OVX) Wistar rats were divided into five groups: control (OVX+Saline), exercise (Exe) (OVX + Exe), Hsp (Hsp) (OVX + Hsp), exercise and Hsp (OVX + Exe + Hsp), and sham-operated. Treatment included either intraperitoneal (i.p) injection of Hsp or saline injection, and also MICT training for 8 weeks. After the end of the treatment, body weight, body mass index (BMI), waist circumference (WC), visceral fat, and serum concentrations of glucose, insulin and lipid profile were measured using colorimetric analysis and ELISA.
Results: Data revealed a significant decrease in weight, waist circumference visceral fat, BMI and levels of glucose, homeostasis model assessment of insulin resistance, triacylglyceride, total cholesterol(p= 0.001), and low-density lipoprotein (LDL) (p= 0.004), but an increase in high-density lipoprotein (p= 0.001)), in OVX+Exe+Hsp compared with the OVX group.
Conclusions: The present study indicates that bioflavonoid Hsp combined with MICT effectively reduces body weight, visceral fat, and LDL, glucose, insulin resistance.
Methods: A total of 40 ovariectomized (OVX) Wistar rats were divided into five groups: control (OVX+Saline), exercise (Exe) (OVX + Exe), Hsp (Hsp) (OVX + Hsp), exercise and Hsp (OVX + Exe + Hsp), and sham-operated. Treatment included either intraperitoneal (i.p) injection of Hsp or saline injection, and also MICT training for 8 weeks. After the end of the treatment, body weight, body mass index (BMI), waist circumference (WC), visceral fat, and serum concentrations of glucose, insulin and lipid profile were measured using colorimetric analysis and ELISA.
Results: Data revealed a significant decrease in weight, waist circumference visceral fat, BMI and levels of glucose, homeostasis model assessment of insulin resistance, triacylglyceride, total cholesterol(p= 0.001), and low-density lipoprotein (LDL) (p= 0.004), but an increase in high-density lipoprotein (p= 0.001)), in OVX+Exe+Hsp compared with the OVX group.
Conclusions: The present study indicates that bioflavonoid Hsp combined with MICT effectively reduces body weight, visceral fat, and LDL, glucose, insulin resistance.
Type of Study: Original Research Article |
Subject:
Medical Biology
Received: 2026/02/6 | Accepted: 2026/06/28
Received: 2026/02/6 | Accepted: 2026/06/28
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