Background and Objective: JWH133 is known to have cannabinoid-2 (CB2) receptor agonist properties. Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is also known to have antinociceptive properties. Endocannabinoids produce analgesia possibly through cyclooxygenase (COX) pathway. The aim of the present work was: to study the effect of celecoxib on JWH133 induced antinociception and to compare the effects of two different dose ranges of celecoxib (mg/kg and nano g/kg) on the JWH133 antiniciceptive effect. Materials and Methods: We have studied the possible interaction of administration of mg/kg (50-200 mg/kg) and Ultra-Low Dose (ULD) (25 and 50 ng/kg) of celecoxib on the antinociceptive effect of intraperitoneal (i.p.) injection of JWH133 using formalin test in mice. Results: JWH133 (0.01, 0.1 and 1 mg/kg) induced antinociceptive effect just in phase I of the formalin test. Celecoxib (50-200 mg/kg) and its ULD (25 and 50 ng/kg) attenuated and potentiated, JWH133 induced antinociception, respectively. Conclusions: It is concluded that JWH-133 induced antinociception is modulated by celecoxib and mg/kg doses of celecoxib showed opposite effects compare to its ultra-low doses.

Background and Objective: Patients’ hospitalization is always stressful for their family members. Belief in God and religiousness are assumed to have vigorous preventive effect on psychiatric disorders, stress and anxiety. Reliance on God can decrease the concerns resulting from severe diseases. When an individual suffers from a long- lasting and complicated disease and its consequent disabilities, trusts in God, would be helpful to admit disease consequences which subsequently prevents or at least diminishes psychological adverse effects. Materials and Methods: This descriptive-correlative study analyzed the level of anxiety in 100 family members of hospitalized patients admitted to the intensive cardiac care units. The anxiety levels in patients’ family members were analyzed using HADS (Hospital Anxiety Depression Scale) and Religious Beliefs Measurements Scale. The reliability and validity of the scales had already been confirmed by Aghamohammadi and coworkers. The results were analyzed using statistical procedures of Chi-square and correlation tests and logistic regression. Results: 53.2% of the individuals were suffering from anxiety and 56.4% had depression. In persons with no anxiety or depression the relation with strong religious beliefs was significant as shown by Chi-square test (P<0.05). However, 31.2% and 33.2% of the patients’ family members who had depression and anxiety respectively, showed a meaningful relation with average religious beliefs (P<0.05). Conclusion: Religious beliefs have a positive effect on reducing depression and anxiety. Reinforcement of beliefs can reduce depression side effects such as suicide attempts, addiction, immoral actions, personality disorders and sexual disorders.

Background and Objective: The handicapped are grappling with many problems, which could jeopardize their mental as well as physical health. Several studies have demonstrated the correlation between religion and mental health. In the recent decades, religion and psychological studies have increasingly attracted the attention of researchers. This study aimed to examine the relationship between religious beliefs and mental health. Materials and Methods: Eighty eight members from Zanjan Handicapped Community (year 2011) constituted the sample for this study. The participants took two tests of Allport's Religious Orientation and General Health Questionnaire (GHQ). These tests have already been translated and standardized for the Iranian society. Using SPSS, the test data were analyzed by descriptive statistics and Pearson's correlation coefficient. Results: The results showed a statistically reversed correlation between global religious score and third subscale of GHQ (how to cope with common life situations) at significance level of 0.01 (r= -0.29 and P= 0.006) and also between internal religious score and the same subscale at significance level of 0.05 (r= -0.224 and P= 0.036). Conclusion: It seems that the handicapped are not aware of the role of faith in their health thus, some measures should be taken in this regard to promote their health.

Background and Objective: Vitamin D deficiency has been implicated in a wide range of conditions such as infectious and autoimmune diseases, cardiovascular and cerebrovascular events, and various malignancies to unfavorable birth outcomes. We studied vitamin D status in a group of neonates with congenital heart disease (CHD) and its relationship with the outcome of heart surgery.
Materials and Methods: Total vitamin D levels in plasma were measured before and 24 hours after the operation in 45 neonates with CHD undergoing heart surgery and in 77 hospitalized neonates without a history of CHD as controls, at Children’s Medical Center between March and September 2018.
Results: Preoperative vitamin D levels in patients with CHD were not significantly different from the control group (42.4 +/- 18.0 versus 46.9 +/- 27.7 nmol/L, P=0.640). Patients’ vitamin D levels decreased postoperatively (42.4 +/- 18.0 versus 36.2 +/- 14.5 nmol/L, P=0.013). This decline was significant in the cyanotic and open-heart surgery groups, but not in non-cyanotic or closed-heart surgery groups. In 41 (91.1%) patients, the outcome was successful discharge from the hospital, in 3 (6.7%), the outcome was demise, and in one, it was not determined due to early discharge. Preoperative and postoperative vitamin D levels did not show any relationship with the outcome. However, logistic regression analysis revealed a significant relationship between the amount of postoperative decline in vitamin D levels and the outcome of death (OR=1.261, 95% CI=1.026-1.551, P=0.028).
Conclusion: Results corroborates previous findings and suggests the amount of postoperative decline in vitamin D levels as a predictor of the outcome of heart surgery in CHD.

Background: Breast cancer (BrCa) is the most prevalent tumor among women globally, aside from nonmelanoma skin malignancies. Unfortunately, many BrCa patients exhibit a poor response to immune checkpoint inhibitors (ICIs) because of a deficiency of infiltrating immune cells. Earlier research has shown that guanylate-binding protein 1 (GBP1) can modify the inhibitory properties of inflammatory cytokines on endothelial cell proliferation, immigration, and invasion.
Objective: Since the fundamental functions of the GBP family in the cancer-immune cycle is uncertain, according to recent findings, the function of GBPs in BrCa was studied. However, the underlying function of the GBP family in the cancer-immunity cycle is uncertain. We decided to study GBPs’ role in BrCa.
Methods: We applied GEPIA, UALCAN, cBioPortal, GeneMANIA, Kaplan-Meier plotter, Human Protein Atlas, STRING, and TIMER in our analysis.
Results: Our results confirmed a strong relation between the expression of GBP1/GBP2/GBP3/GBP4/GBP5/GBP6/GBP7 and the infiltration of all immune cells. Specifically, high GBP1/4/5 expression was strongly linked with increased infiltration of dendritic cells, B cells, CD4+ T cells, CD8+ T cells, and neutrophils in BrCa, whereas GBP2/3/6/7 expression showed a weaker positive correlation.
Conclusion: These results suggest a therapeutic assessment for the GBP family in combination with ICIs for treating BrCa.