The Coronavirus infectious disease 2019 (COVID-19) has recently emerged as a pandemic and has endangered the lives of thousands of people worldwide. No specific treatment has been identified so far. However, the identification of diagnostic and prognostic factors in patients can be valuable for the application of preventive strategies. Increased platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), prothrombin time (PT), and D-dimer indices have been found in patients with increased inflammation and thrombosis and can lead to heart disease. Also, an increase in these indices is accompanied by worsening of the disease and impairment of the respiratory tract, which necessitates ventilation for the patients eventually. The evaluation of NLR, PLR, and coagulation parameters can be useful for identifying high-risk individuals who need to be intubated. Patient survival will improve by the timely identification and the use of appropriate treatment strategies.

From the first reported case of Coronavirus disease 2019 (COVID-19) on December 30, 2019 in Wuhan, China, the number of confirmed cases of the disease has been increased continuously and exponentially up to now. The event has emerged as a clear threat to global health such that the World Health Organization (WHO) officially declared the outbreak of the disease a pandemic on March 11, 2020. The disease has infected approximately 195,000 people and killed about 7,700 in the Eastern Mediterranean Region. As COVID-19 is spreading globally, its economic consequences also mounting across all countries. This perspective research designed to examine briefly the economic consequences of COVID-19 on the Middle East and North Africa (MENA) Region Countries.

Coronavirus disease (COVID-19) can induce coagulopathy at the base of sepsis-induced coagulopathy (SIC), which is an important cause of death in these patients. Cytokine storm causes imbalance in coagulation and fibrinolytic system. A combination of hypercoagulability state, decrease or inhibition of fibrinolysis and endotheliopathy causes thromboembolic events. Underlying diseases such as diabetes and hypertension with a high rate of mortality in COVID-19 and some conditions like aging and obesity are the main disorders with hemostatic disturbance and increase of coagulopathy. Therefore, it seems that the combination of COVID-19 infection and these risk factors increase the risk of thromboembolic complications all together.

Currently, efforts have focused on dealing with the emerging coronavirus disease 2019 (COVID-19) worldwide. Hopefully, information technology can be applied to meet the challenges related to the pandemic and biosurveillance. Free and open-source software (FOSS) model has emerged as an effective tool against these challenges. The main objective of this study was to determine and summarize the application of FOSS in published and released resources and materials against COVID-19. This review includes projects that were available through GitHub and SourceForge reliable web-based materials. All projects were identified between January 1 and April 10, 2020. Search terms in GitHub and SourceForge were based on clinical terminologies, such as COVID-19, COVID, Covid19, and Corona Virus. Inclusion or exclusion criteria were used to filter the results. Finally, a screening procedure was followed to achieve the most related records. We identified 46,426 records in GitHub and seven projects in SourceForge. The top 40 projects were included. The results show that a high percentage of FOSS projects against COVID-19 were related to visual dashboards. The open dataset and analytical methods made a significant contribution to this context. Previously learned lessons from FOSS have shown that the explained projects would play important roles in future epidemics by forking and joining in new projects, which formed around a specific problem.

 Background and Objective: SARS COV-2 is a worldwide pandemic disease. There is currently no effective cure for this virus, but some types of herbs can be a good choice for reducing its symptoms. There are some reports that Thymus Vulgaris has a high antioxidant compounds effective in strengthening the immune system, as well as anti-virus effects to reduce the respiratory symptoms. Therefore, we speculated that Thymus Vulgaris could be useful for reducing some of the symptoms in patients suffering from COVID- 19.
 Materials and Methods: First, thyme essential oil was prepared and a questionnaire regarding the patients’ symptoms was designed. Then, 83 patients with COVID-19 were randomly selected and divided into control group and thyme receiving group (TRG). The questionnaire was completed and emphasized to consume 5 mL of the syrup or essential oil three times per day. Finally, one week after the first visit, the questionnaire was completed again to determine the effects of thyme on the mentioned symptoms. Finally, the test results were reviewed and reported.
 Results: The results one week after taking thyme showed that, the fever (p<0.027), dizziness (p<0.003), cough, dyspnea, muscular pain, headache, anorexia, weakness and lethargy, fatigue, and chest wall pain were significantly reduced (p<0.001). Also, BUN (p<0.004), neutrophil count (p<0.001), and calcium (p<0.034) decreased but, lymphocyte count was increased significantly (p<0.001).
 Conclusion: Thyme plant which has high antioxidant properties, strengthens the immune system, and induces the antiviral effect could reduce the symptoms of coronavirus; therefore, it is recommended for reducing the symptoms of COVID-19.

This study aimed to report histopathological features and serological outputs of the lung, heart and liver in a patient suffered from Coronavirus disease-2019 (COVID-19). A woman was admitted to the Razi Hospital, Rasht city, Iran with the symptoms of cough, dyspnea, fever and myalgia. She had also Parkinson’s disease (PD); she had no history of respiratory, cardiovascular, renal and gastrointestinal diseases and alcohol consumption. COVID-19 infection was proved by the Real time-PCR (RT–qPCR) test. The required specimen was obtained from nasopharyngeal swab; however, lung radiologic findings revealed atypical signs of COVID-19. The patient expired after 8 days of admission. After death, needle biopsy was performed for histopathologic evaluation of the heart, lung and liver tissues. The RT–qPCR was performed to evaluate the presence of Coronavirus in the tissues. The pathological biopsies showed advanced alveolar damages in the lung, periportal inflammation in the liver, spread steatosis in the hepatocytes and moderate myocarditis in the heart. However, the RT-qPCR test was negative for these tissues, but alterations in the above-mentioned areas may be due to the secondary side effects of COVID-19 infection or pharmacological treatments.

   Background & Objective: Since the clinical and epidemiologic characteristics of coronavirus disease 2019 (COVID-19) is not well known yet, investigating its origin, etiology, diagnostic criteria, clinical manifestations, risk factors, treatments, and other related aspects is extremely important. In this situation, clinical experts face many uncertainties to make decision about COVID-19 prognosis based on their judgment. Accordingly, this study aimed to determine the diagnostic criteria for COVID-19 as a prerequisite to develop clinical diagnostic models.
 Materials & Methods: In this retrospective study, the Enter method of the binary logistic regression (BLR) and the Forward Wald method were used to measure the odds ratio (OR) and the strength of each criterion, respectively. P-value<0.05 was considered as statistically significant for bivariate correlation coefficient.
 Results:  Phi-Crammer’s examination test showed that 12 diagnostic criteria were statistically important; measuring OR revealed that six criteria had the best diagnostic power. Finally, true classification rate and the area under receiver operative characteristics curve (AUC) were calculated as 90.25% and 0.835, respectively.
 Conclusion:  Identification of diagnostic criteria has become the standard approach for disease modeling; it helps to design decision support tools. After analyzing and comparing six diagnostic performance measures, we observed that these variables have a high diagnostic power for COVID-19 detection.

Background and Objective: The behavior of COVID-19, clinical symptoms, and mortality rate are not the same in different regions. Due to lack of knowledge about the cited issues, we aimed to investigate the clinical symptoms, case fatality rate, and some risk factors of COVID-19.
Materials and Methods: This longitudinal study was started from the late February 2020 and lasted to the mid-July 2020 in Jiroft, Kerman province, Iran. The course of the disease, clinical signs and symptoms, underlying diseases, patients' exposure history, travel history, adherence to health instructions, and the fatality rate of the disease were evaluated in the patients. The descriptive statistics and frequency were analyzed in different groups using IBM SPSS statistics version 20.
Results: In this study, 2977 definitive cases of COVID-19 were detected using RT-PCR test. The frequent clinical symptoms were fever (45.2%), body aches and bruises (38.8%), and cough (36.4%), respectively. The fatality rate of the disease was 4%. Evaluation of the patients’ exposure history showed that almost 50% of the cases had no exposure. Among the studied individuals, 33% had the history of exposure to a definite COVID-19 case.
Conclusion: Personal hygiene, social distancing, and use of face mask are of great importance in reducing the disease morbidity and mortality. Public awareness about COVID-19 should also be increased, especially in the elderly individuals with the history of underlying and chronic diseases.

Novel coronavirus causes the outbreak of COVID-19. There is still no verified treatment regimen against this novel virus; however, different drugs and compounds have been tested against it. Ample proposals have led to a good understanding of pathogenesis and drug efficacy against the novel virus disease. Excess systemic inflammation, which is described as cytokine storm, in the severe cases of COVID-19 can pass through the blood-brain barrier, enter the brain tissue, and activate the microglial cells and oligodenritcytes. Activation of the microglia cells and oligodenritcytes can increase generation of reactive oxygen species in the brain. Excess generation of reactive oxygen species can in turn increase neuro-inflammation in some cases of patients with COVID-19. Treatment of COVID-19 is far from clear. Today, some antiviral drugs such as remdisivir, favipiravir, ribavirin, kaletra, and arbidol are being tested against the disease. Besides these drugs, corticosteroids, anti-malaria drugs (such as chloroquine family), anticoagulants (such as heparin or enoxaparin) are repurposed. In this paper, first we explained the pathogenesis of COVID-19 particles, particularly in the brain. Second, we reviewed recent treatment options up to now, including interferon therapy, convalescent plasma exchange, plasmapheresis, immunoglobin therapy, and use of specified monoclonal anti-bodies in COVID-19 patients.

COVID-19 spread rapidly worldwide and became a pandemic disease in April 2020. During this period, various medical complications of this disease have been reported, but less attention has been paid to the cognitive aspects caused by the pandemic. In this review article, an attempt has been made to address the cognitive aspects of COVID-19 disease. Importantly, this disease has caused people to use their hands lesser than before the pandemic. It also forces the people to escape from the contaminated regions. In addition, mental fatigue resulting from long-term quarantine and staying at home, social jet lag due to changes in the hours of use of artificial light, economic problems, and poverty resulting from a long-lasting lockdown, are also the consequences of the pandemic. All of these consequences can be led to chronic psychological stress, which may induce several metabolic, immunological, cardiovascular, and psychological impairments and/or disorders. These outcomes indicate that the COVID-19 pandemic is a complicated issue that would not be resolved by considering the epidemiologic rules. There is an urgent need for a new branch of science which could be called “Pandemiology”, which could be categorized as a sub-branch of cognitive science. Pandemiology seems to be an interdisciplinary science and uses the social sciences, psychology, neuroscience, art, economy, politics, medicine, biology, media, and other sciences to better deal with the complications of such emerging pandemics.

Background and Objective: Screening and timely diagnosis of positive individuals is one of the important issues in controlling pandemic of Covid-19. Early and timely diagnosis of asymptomatic individuals, contact tracking, disconnection of Covid-19 transmission chain through early detection of patients and decreasing R0 were the main objectives of the current study.
Materials and Methods: The Covid-19 outpatient sampling detection project started in Zanjan province on March 26, 2020 and samples were taken from people suspected of having Corona Virus and people in contact with these patients.
Results: All 31,937 cases (48% male, 52% female) who had referred to Comprehensive Health Care Centers until May 16, 2020, were selected. A considerable percentage of incidences were observed in Zanjan and Khodabandeh cities. 20% of the examined samples had positive results. A substantial incidence was found in the age group of over 70 -year- old. Following implementation of the outpatient screening project, R0 fell below 1 in the province.
Conclusion: Prior to the implementation of Covid-19 laboratorial outpatient screening project, the value of R0 was 1.4 in Zanjan province. However, this value fell below 1, after implementation of the laboratorial outpatient screening indicating that the principal way to effectively control Covid -19 is to detect positive cases and manage them.

Background and Objective: COVID-19 was first seen in Wuhan-China in December 2019, and became a widely- spreadepidemic and caused a terrifying life-threatening problem in most societies of the world. In Iran, a declaration was made on  January 20, 2020, and all health systems were alerted of the disease threats.
Materials and Methods: We collected all chest CT scans of 200 cases diagnosed as COVID-19 who died in 22 hospitals of Golestan Province, Iran. All data were collected in a designed checklist, then statistical evaluation  was made using descriptive analysis and Chi-Square test.
Results: The most frequent complaints in patients were dyspnea (38.5%), fever(15%), and dry cough (13%) . Hypertension (22.5%), Heart disease (18.5%), and diabetes (15%) were present as underlying diseases. CT scan findings showed Ground Glass Opacity (96%), consolidation (44%), pleural effusion (26.5%), crazy paving (15%), and cardiomegaly (15.5%).
Conclusion: Based on this study, hypertension as an underlying disease was significantly related to Highly Suggestive CT scans. No relation was found between cardiomegaly and death under 48 hours. Our findings Showed Ground Glass Opacity (GGO) in 192 (96%), consolidation  in 88 (44%), crazy paving in 30 (15%), cardiomegaly in 30 (15%), and pleural effusion in 53 (26.5%) cases.

Background and Objective: COVID-19 is a serious disease with different symptoms and risk factors infecting and killing many people around the world. This study was performed to investigate the demographic and clinical characteristics of COVID-19 suspects referred to the hospitals and coronavirus treatment centers of Shahroud, Iran.
Materials and Methods: Upon the outbreak of the COVID-19 epidemic in Shahroud, Shahroud University of Medical Sciences launched a project to systematically record the demographic, clinical, and medical data of all suspects referred to the Corona Center. In this study, the data of 3945 suspected people collected during 5 months were analyzed. The RT-PCR test was used as the criterion for diagnosing the disease.
Results: Among 3945 suspected cases, 24.4% had positive RT-PCR test. The mean age of confirmed cases was 52.16 years. Dry cough and fever in addition to anorexia were reported as the most common symptoms. The results of logistic regression analysis showed that people over 60 years with heart disease reduce the risk, while people over 60 years, diabetics, and obese people increase the risk of infection.
Conclusion: These results necessitate further lines of research into different symptoms and risk factors to help identify COVID-19 cases earlier and start faster treatment.

A number of studies have previously provided evidence on the Anti-inflammatory properties of plant-derived compounds that can prevent lung injury. In this study, we attempted to analyze the therapeutic effects of PM 014 on inflammation and pulmonary fibrosis in COVID-19 as well as describing the treatment of one of the most challenging problems related to the coronavirus-19 (COVID-19). We believe that having a close look at all angles of the proposed mechanism goes beyond the physiological consequences of a way to design new strategies for providing an appropriate treatment.

Background and Objective: Measurement of inflammatory markers and lactate dehydrogenase (LDH) may contribute to the evaluation of lung involvement severity. This study aimed to evaluate relationship between severity of primary lung involvement with highest level of erythrocyte sedimentation rate (ESR) and LDH in patients with COVID-19.
Materials and Methods: This descriptive-analytical study was conducted on 123 patients with COVID-19 in Shahid Sadoughi Hospital. Data including age, gender, ESR (mm/h), LDH (U/L), and high-resolution Computed Tomography scan (HRCT) findings and hospitalization ward were extracted from medical records. The regression model was used to determine the relation between HRCT findings with LDH and ESR.
Results: Mean LDH, ESR, and HRCT findings were 508.41±224.65, 52.23±29.56, and 37.17± 22.18 respectively. A significant relation was seen between HRCT findings with highest level of LDH and ESR (P=0.001). A significant relation was observed between the highest levels of ESR and HRCT findings, regarding age, gender, and hospitalization wards (P<0.01). There was a significant relation between the highest level of LDH and HRCT findings regarding age group and hospitalization wards (P<0.01).
Conclusion: A significant relation was seen between HRCT findings and highest levels of ESR and LDH in patients with COVID-19. Therefore, it seems that assessment of laboratory findings such as LDH and ESR can be helpful as cost-effective markers instead of chest CT scan for predicting the severity of lung injury when the CT scan report is controversial. The relation between HRCT findings with LDH and ESR were affected by age and hospitalization ward. However, more studies should be conducted in this regard.

Background and Objective: Hospital readmissions are common and expensive. Identifying the patients who are at high risk of readmission can decrease readmission. Hence, in the present study, the clinical characteristics, biomarker results, and Computed Tomography (CT) criteria of all the readmitted patients were assessed.
Materials and Methods: Data of 98 readmitted patients to the Baqiyatallah Hospital in Tehran reviewed from December 22, 2019 through June 20, 2020. We classified the readmitted patients into three groups: patients (1) without COVID-19 symptoms, (2) with suspected COVID-19, and (3) with confirmed COVID-19 infection.
Results: Our data revealed that the frequency of gender was significantly different between groups (with higher frequency for men). The duration between two admissions were significantly low in the confirmed COVID-19 group. Ischemic heart disease, hypertension, and diabetes mellitus were more common in confirmed COVID-19 group. High levels of CRP, and ESR detected in the confirmed COVID-19 group. During the first admission, the count of WBC was significantly lower in the confirmed COVID-19 group, the RBC count and hemoglobin level was significantly higher in both the first and second admission in the confirmed COVID-19 group. Most of the patient’s had bilateral lung lesions and ground glass opacities (GGO) in their CT Scans in the second admission.
Conclusion: Our data suggested that the older men and ischemic heart disease, hypertension and diabetes mellitus had a high risk of hospital readmission in COVID-19. The confirmed COVID-19 group showed a shorten time to be readmitted.

The 2019 Coronavirus disease pandemic (COVID-19) has spread to over two hundred countries worldwide, affecting > 170 million people and causing >3,500,000 deaths (May 29, 2021). Severe COVID-19 disease mostly disturbs the respiratory system, but gastrointestinal symptoms, including vomiting, nausea and diarrhea, are also present. Herein, we are reporting a COVID-19 patient with acute pancreatitis (AP) in Zanjan, Iran. . This patient showed acute pancreatitis as a COVID-19-related complication, emphasizing the importance of evaluating pancreas-specific plasma amylase levels in patients with COVID-19 and intestinal cramping.

Importance of this therapeutic method in Iran is more prominent than other countries in the world for two main reasons; the first one is plant richness, biodiversity, having 11 climates of 13 world-known climates, and diversity of 8000 plant species that are considered as an exclusive capacity in Iran. The second is considering the possibility of inadequate access to medicine at the international level for various reasons, including the lack of financial resources needed to prepare the drug, possible sanctions, or time-consuming access, which makes it even more necessary to pay attention to the importance of herbal medicines. According to what has been mentioned above, two short-term and long-term approaches are proposed to benefit from the regional capacity and potential of medicinal plants and to compensate for the lost date of medicinal plants.
In the short-term solution, the codification and immediate implementation of comprehensive and infrastructure programs to prevent and manage the outbreak of the covid19 disease by highlighting the role of prevention in families. To reach this goal, we need to educate, and aware people of how to exploit and utilize medicinal plants effectively to strengthen their immune systems and also to treat this disease. The long-term approach is having the support of the government and policymakers in recognition the ancient Iranian medicine, valuing and designating funding in expanding researches in this field, advocacy the existing centers of traditional medicine, preventing the easy sailing of related raw products, and considering medicinal plants in the medical structure of the country.

This case study includes three pregnant women with COVID-19 diagnosed during pregnancy or delivery between March 28 and May 13, 2020. All cases were confirmed by a positive pharyngeal reverse transcription polymerase chain reaction (RT-PCR) test and one case by computed tomography scan (CT Scan) in addition to the (RT-PCR). Clinical and laboratory information was extracted from hospital records during pregnancy and delivery. The adverse effects during pregnancy and after the birth of the newborn, the possibility of vertical transmission from positive pregnant mothers to the neonates were investigated. Of the three women with COVID-19 infection, one patient was diagnosed two weeks before delivery and two were diagnosed during delivery and hospitalization. No adverse effects including preeclampsia, gestational hypertension, rupture of the amniotic sac during pregnancy and premature delivery were observed but one of the patients suffered from intrauterine fetal death (IUFD). in this study,  adverse pregnancy outcome was not observed in  pregnant women with Covid-19  infection  based on hospital observations. No vertical transmission was observed following vaginal delivery or cesarean section and during pregnancy. As the effect of the virus on different people in society varies according to their individual characteristics, our conclusion in this study on pregnant women is also affected by these individual differences, which requires further studies in this field with more samples.