Background and Objective: Toxoplasma gondii is one of the most prevalent human parasites globally distributed with a wide range of hosts including humans and animal species. The available anti-toxoplasma treatments have faced several problems. To deal with these issues new drugs and compounds are required to be evaluated. This study was aimed to evaluate the inhibitory effect of ethanol extracts of propolis on acute toxoplasmosis in mouse model.

Materials and Methods: A total of 40 BALB/c mice with average weight of 20-25 gr, were divided into 8 groups of 5. Each mouse was inoculated intraperitoneally with parasitic suspension of approximately 10,000 tachyzoites. Two groups of mice, including a non-infected group and an infected but not treated group were used as control. Twenty-four hours after the infection, treatment was initiated for six groups, inoculating 25, 50, 100, 150, 200, and 300 mg/kg of propolis extracts orally for 7 days.

Results: The average survival time was 6.4 to 7.2 days in the propolis treated groups of mice and 4.6 days in the control group, that was significantly different. The number of Toxoplasma tachyzoites in the test groups was significantly lower than the control group (P< 0.05). It was 10×104 in the group of 300mg and 20.4×104 in the control group with minimum and maximum parasite numbers, respectively. The most effective dose of propolis extract on survival time of the infected mice was 150 mg/kg.

Conclusion: The results indicated that the propolis ethanol extracts can relatively inhibit Toxoplasma infection development in mouse model.

Background and Objective: Bacterial vaginosis is the most common cause of vulvovaginits in reproductive- aged women. Metronidazole which is considered as the first -line treatment accompanies a few side effects. Besides, many women prefer to use herbal therapy for the treatment of vaginitis. This study was carried out to compare the effect of Propolis vaginal cream with Metronidazole vaginal gel on the treatment of bacterial vaginosis in reproductive -aged women.

Materials and Methods: Based on Amsel’s criteria and gram stain, the afflicted patients were diagnosed and were randomly assigned to two groups of 50 to receive treatments with Metronidazole or Propolis. The results were compared after 7 days of therapy.

Results: There was a significant relationship between groups in terms of type of treatment and recovery based on Amsel’s criteria (P<0/05). The response to the treatment in the groups of Metronidazole and Propolis were 95.8 % and 70.8%, respectively.

Conclusion: Although Propolis had a weak effect on the improvement of Amsel’s criteria and nugent score changes, but responses to the treatment in Propolis group was considerable (70.8%). So Propolis can be used as a complimentary treatment besides the main therapy.